Expression of Two X-Linked Genes in Human Hair Follicles of Double Heterozygotes

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 68; no. 7; pp. 1425 - 1427
• Main Authors: Goldstein, Joseph L., Marks, James F., Gartler, Stanley M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01.07.1971; National Acad Sciences
• Subjects: Adenine - metabolism; Adenine Nucleotides; Adolescent; Adult; Alleles; Biological Sciences: Genetics; Carbon Isotopes; Child; Electrophoresis; Female; Follicles; Genes; Genetic loci; Genetics, Medical; Glucosephosphate Dehydrogenase - analysis; Guanine Nucleotides; Hair - enzymology; Hair follicles; Heterozygote; Heterozygotes; Humans; Hypoxanthines; Isoenzymes - analysis; Lesch-Nyhan Syndrome - enzymology; Male; Middle Aged; Mutation; Pentosephosphates; Phenotypes; Radioisotopes; Sex Chromosomes; Transferases - analysis; Tritium; X Chromosome inactivation; X linked genes

Expression of the two X-linked loci glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) and hypoxanthine:guanine phosphoribosyltransferase (HGPRT; EC 2.4.2.8) was studied in single hair follicles of two females who were heterozygous for both of these genes (double heterozygotes). The coupling phas...