Bone Morphogenetic Protein 9 Protects Against Myocardial Infarction by Improving Lymphatic Drainage Function and Triggering DECR1-Mediated Mitochondrial Bioenergetics

• Published in: Circulation (New York, N.Y.) Vol. 150; no. 21; pp. 1684 - 1701
• Main Authors: Duan, Zikun, Huang, Zhouqing, Lei, Wei, Zhang, Ke, Xie, Wei, Jin, Hua, Wu, Maolan, Wang, Ningrui, Li, Xiaokun, Xu, Aimin, Zhou, Hao, Wu, Fan, Li, Yulin, Lin, Zhuofeng
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 19.11.2024
• Subjects: Animals; Energy Metabolism; Growth Differentiation Factor 2 - genetics; Growth Differentiation Factor 2 - metabolism; Humans; Lymphatic Vessels - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart - metabolism; Mitochondria, Heart - pathology; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; lymphatic drainage dysfunction; BMP9; mitochondrial bioenergetics; myocardial infarction; DECR1

BACKGROUND: BMP9 (bone morphogenetic protein 9) is a member of the TGF-β (transforming growth factor β) family of cytokines with pleiotropic effects on glucose metabolism, fibrosis, and lymphatic development. However, the role of BMP9 in myocardial infarction (MI) remains elusive. METHODS: The expre...