Prolonged Reactive Oxygen Species Generation and Nuclear Factor-κB Activation after a High-Fat, High-Carbohydrate Meal in the Obese

• Published in: The journal of clinical endocrinology and metabolism Vol. 92; no. 11; pp. 4476 - 4479
• Main Authors: Patel, Chinmay, Ghanim, Husam, Ravishankar, Shreyas, Sia, Chang Ling, Viswanathan, Prabhakar, Mohanty, Priya, Dandona, Paresh
• Format: Journal Article
• Language: English
• Published: Washington Oxford University Press 01.11.2007; Copyright by The Endocrine Society
• Subjects: Carbohydrates; Inflammation; Leukocytes (mononuclear); Matrix metalloproteinase; Meals; Metalloproteinase; Obesity; Reactive oxygen species

Background: Because obesity is associated with chronic oxidative and inflammatory stress, and high-fat, high-carbohydrate meals induce significant oxidative and inflammatory stress in normal subjects, we have now hypothesized that the intake of a high-fat, high-carbohydrate meal would result in a gr...