Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction

• Published in: Circulation (New York, N.Y.) Vol. 150; no. 11; pp. 867 - 883
• Main Authors: Jheng, Jia-Rong, Bai, Yang, Noda, Kentaro, Huot, Joshua R., Cook, Todd, Fisher, Amanda, Chen, Yi-Yun, Goncharov, Dmitry A., Goncharova, Elena A., Simon, Marc A., Zhang, Yingze, Forman, Daniel E., Rojas, Mauricio, Machado, Roberto F., Auwerx, Johan, Gladwin, Mark T., Lai, Yen-Chun
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 10.09.2024
• Subjects: heart failure, diastolic; pulmonary heart disease; Sirtuin 3; musculokeletal abnormalities; XXX

BACKGROUND: Pulmonary hypertension (PH) is a major complication linked to adverse outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies exist for PH associated with HFpEF (PH-HFpEF). We have recently reported on the role of skeletal muscle SIRT3 (sirtuin-3) in...