Comparison of a fixed-dose combination of Celecoxib/PG201 [Layla®] versus co-administration of individual formulations in healthy participants: A randomized trial

• Published in: Medicine (Baltimore) Vol. 103; no. 46; p. e40494
• Main Authors: Song, Ji Hye, Koh, Hyunsook, Moon, Hyun-Young, Jung, Jin-Gyu, Hong, Jang Hee, Sunwoo, Jung
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 15.11.2024
• Subjects: Adult; Celecoxib - administration & dosage; Celecoxib - adverse effects; Celecoxib - pharmacokinetics; Clinical Trial/Experimental Study; Cross-Over Studies; Cyclooxygenase 2 Inhibitors - administration & dosage; Cyclooxygenase 2 Inhibitors - adverse effects; Cyclooxygenase 2 Inhibitors - pharmacokinetics; Drug Combinations; Female; Healthy Volunteers; Humans; Male; Middle Aged; Plant Extracts - administration & dosage; Plant Extracts - adverse effects; Plant Extracts - pharmacokinetics; Young Adult; pharmacokinetics; herbal medicines; osteoarthritis; safety profile

Background: Osteoarthritis (OA) is a prevalent joint disease affecting the spine, hands, hips, knees, and feet. However, definitive drugs for OA are lacking, and current treatments are limited owing to inconvenient administration, inadequate functional improvement, and long-term side effects includi...