Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls

• Published in: PloS one Vol. 14; no. 3; p. e0213202
• Main Authors: Bakker, Guido J., Vanbellinghen, Manon C., Scheithauer, Torsten P., Verchere, C. Bruce, Stroes, Erik S., Timmers, Nyanza K. L. M., Herrema, Hilde, Nieuwdorp, Max, Verberne, Hein J., van Raalte, Daniël H.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2019; Public Library of Science (PLoS)
• Subjects: Aged; Beta cells; Biology and Life Sciences; Blood; Blood Glucose - analysis; Blood levels; Body mass; Body mass index; Body size; Computed tomography; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diagnostic systems; Family medical history; Fasting; Female; Fluorine isotopes; Fluorodeoxyglucose F18 - chemistry; Fluorodeoxyglucose F18 - metabolism; Glucose; Humans; Hyperglycemia; Inflammation; Insulin; Internal medicine; Laboratories; Linear Models; Male; Medical imaging; Medicine and Health Sciences; Metabolism; Middle Aged; Muscles; Muscles - metabolism; Nuclear medicine; Pancreas; Pancreas - metabolism; Pancreatic cancer; Patients; Physical Sciences; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - metabolism; Research and Analysis Methods; Retrospective Studies; Tomography; Netherlands

Increasing evidence indicates that the development of type 2 diabetes is driven by chronic low grade beta-cell inflammation. However, it is unclear whether pancreatic inflammation can be noninvasively visualized in type 2 diabetes patients. We aimed to assess pancreatic 18F-FDG uptake in type 2 diab...