Hemolin, an immunoglobulin-like peptide, opsonizes nonself targets for phagocytosis and encapsulation in Spodoptera exigua, a lepidopteran insect
Hemolin is an immunoglobulin-like peptide that plays crucial role in microbial pathogen surveillance. However, its specific molecular actions in immune responses remain largely unclear. This study focused on the modulation of hemocyte phagocytosis of hemolin via its opsonin activity. A full length o...
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| Published in | Journal of Asia-Pacific entomology Vol. 22; no. 3; pp. 947 - 956 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.09.2019
한국응용곤충학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-8615 1876-7990 |
| DOI | 10.1016/j.aspen.2019.08.002 |
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| Abstract | Hemolin is an immunoglobulin-like peptide that plays crucial role in microbial pathogen surveillance. However, its specific molecular actions in immune responses remain largely unclear. This study focused on the modulation of hemocyte phagocytosis of hemolin via its opsonin activity. A full length open reading frame (ORF) of hemolin (SeHem) was identified in the beet armyworm, Spodoptera exigua. Its ORF encoded 418 amino acids and shared 37.3–93.3% sequence similarities with other lepidopteran hemolins. SeHem was expressed in all developmental stages of S. exigua. In larval stage, SeHem was mostly expressed in hemocytes. Immune challenge significantly increased SeHem expression in hemocytes, fat body, midgut, and epidermis. RNA interference (RNAi) was performed by injecting SeHem-specific double-stranded RNA (dsRNA) into hemocoel, resulting in 60–80% reduction of SeHem transcript levels at 24–48 h after injection. Under RNAi condition, larvae showed significant loss of phagocytotic activities. In addition, hemocytes collected from control larvae exhibited significant reduction in phagocytosis when they were overlaid with plasma obtained from RNAi-treated larvae. RNAi treatment also suppressed encapsulation against injected beads. Furthermore, RNAi-treated larvae became highly susceptible to entomopathogenic bacteria. These results suggest that hemolin can act as opsonin in cellular immune responses to protect S. exigua against infections by entomopathogens.
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•Hemolin is identified and highly expressed in hemocytes of Spodoptera exigua.•Hemolin acts as opsonin between bacteria and hemocytes.•RNA interference of hemolin expression led to immunosuppression. |
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| AbstractList | Hemolin is an immunoglobulin-like peptide that plays crucial role in microbial pathogen surveillance. However, its specific molecular actions in immune responses remain largely unclear. This study focused on the modulation of hemocyte phagocytosis of hemolin via its opsonin activity. A full length open reading frame (ORF) of hemolin (SeHem) was identified in the beet armyworm, Spodoptera exigua. Its ORF encoded 418 amino acids and shared 37.3–93.3% sequence similarities with other lepidopteran hemolins. SeHem was expressed in all developmental stages of S. exigua. In larval stage, SeHem was mostly expressed in hemocytes. Immune challenge significantly increased SeHem expression in hemocytes, fat body, midgut, and epidermis. RNA interference (RNAi) was performed by injecting SeHem-specific double-stranded RNA (dsRNA) into hemocoel, resulting in 60–80% reduction of SeHem transcript levels at 24–48 h after injection. Under RNAi condition, larvae showed significant loss of phagocytotic activities. In addition, hemocytes collected from control larvae exhibited significant reduction in phagocytosis when they were overlaid with plasma obtained from RNAi-treated larvae. RNAi treatment also suppressed encapsulation against injected beads. Furthermore, RNAi-treated larvae became highly susceptible to entomopathogenic bacteria. These results suggest that hemolin can act as opsonin in cellular immune responses to protect S. exigua against infections by entomopathogens. KCI Citation Count: 0 Hemolin is an immunoglobulin-like peptide that plays crucial role in microbial pathogen surveillance. However, its specific molecular actions in immune responses remain largely unclear. This study focused on the modulation of hemocyte phagocytosis of hemolin via its opsonin activity. A full length open reading frame (ORF) of hemolin (SeHem) was identified in the beet armyworm, Spodoptera exigua. Its ORF encoded 418 amino acids and shared 37.3–93.3% sequence similarities with other lepidopteran hemolins. SeHem was expressed in all developmental stages of S. exigua. In larval stage, SeHem was mostly expressed in hemocytes. Immune challenge significantly increased SeHem expression in hemocytes, fat body, midgut, and epidermis. RNA interference (RNAi) was performed by injecting SeHem-specific double-stranded RNA (dsRNA) into hemocoel, resulting in 60–80% reduction of SeHem transcript levels at 24–48 h after injection. Under RNAi condition, larvae showed significant loss of phagocytotic activities. In addition, hemocytes collected from control larvae exhibited significant reduction in phagocytosis when they were overlaid with plasma obtained from RNAi-treated larvae. RNAi treatment also suppressed encapsulation against injected beads. Furthermore, RNAi-treated larvae became highly susceptible to entomopathogenic bacteria. These results suggest that hemolin can act as opsonin in cellular immune responses to protect S. exigua against infections by entomopathogens. [Display omitted] •Hemolin is identified and highly expressed in hemocytes of Spodoptera exigua.•Hemolin acts as opsonin between bacteria and hemocytes.•RNA interference of hemolin expression led to immunosuppression. Hemolin is an immunoglobulin-like peptide that plays crucial role in microbial pathogen surveillance. However, its specific molecular actions in immune responses remain largely unclear. This study focused on the modulation of hemocyte phagocytosis of hemolin via its opsonin activity. A full length open reading frame (ORF) of hemolin (SeHem) was identified in the beet armyworm, Spodoptera exigua. Its ORF encoded 418 amino acids and shared 37.3–93.3% sequence similarities with other lepidopteran hemolins. SeHem was expressed in all developmental stages of S. exigua. In larval stage, SeHem was mostly expressed in hemocytes. Immune challenge significantly increased SeHem expression in hemocytes, fat body, midgut, and epidermis. RNA interference (RNAi) was performed by injecting SeHem-specific double-stranded RNA (dsRNA) into hemocoel, resulting in 60–80% reduction of SeHem transcript levels at 24–48 h after injection. Under RNAi condition, larvae showed significant loss of phagocytotic activities. In addition, hemocytes collected from control larvae exhibited significant reduction in phagocytosis when they were overlaid with plasma obtained from RNAi-treated larvae. RNAi treatment also suppressed encapsulation against injected beads. Furthermore, RNAi-treated larvae became highly susceptible to entomopathogenic bacteria. These results suggest that hemolin can act as opsonin in cellular immune responses to protect S. exigua against infections by entomopathogens. |
| Author | Sajjadian, Seyede Minoo Jung, Jihyeon Kim, Yonggyun |
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| SubjectTerms | amino acids cell-mediated immunity double-stranded RNA Encapsulation entomopathogenic bacteria fat body hemocoel hemocytes Hemolin immune response Immunity insects larvae messenger RNA midgut monitoring open reading frames Opsonin peptides Phagocytosis RNA interference sequence homology Spodoptera exigua 농수해양학 |
| Title | Hemolin, an immunoglobulin-like peptide, opsonizes nonself targets for phagocytosis and encapsulation in Spodoptera exigua, a lepidopteran insect |
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