Shuangshi Tonglin capsule improves chronic prostatitis through the SIRT-1/AMPK and MAPK signalling pathways

• Published in: Heliyon Vol. 9; no. 11; p. e21745
• Main Authors: Liu, Qing, Zhang, Xinyue, Mao, Peng, Wang, Ziqiang, Mao, Qian, Wang, Chuan, Liu, Jiping, Zhu, Xingmei, Wang, Baoan, Wei, Hao
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2023; Elsevier
• Subjects: AMPK/SIRT-1; Chronic prostatitis; Inflammation; MAPK; Oxidative stress; Shuangshi Tonglin capsule; Oxidative stress; GSH-PX; IHC; H&E; Inflammation; MDA; MAPK; CP; PVDF; Shuangshi Tonglin capsule; AMPK/SIRT-1; SDS-PAGE; TH; CMC-Na; CAT; SSTL capsule; PI; T-SOD; Chronic prostatitis

To explore the effects of the Shuangshi Tonglin (SSTL) capsule on CP/CPPS and reveal the therapeutic mechanisms. A CP/CPPS rat-model group received an intraprostatic injection of CFA. SSTL capsule were administered daily by oral gavage at doses of 1.25, 2.5, and 5.0 g/kg for 28 days. Pain threshold...