Inhibitory Effect of Sulfaguanidine on the Biosynthesis of Thiamine in Rats and the Beneficial Role of Penicillin and Hydrolyzed Glucose Cycloacetoacetate

When rats were fed sulfaguanidine together with a thiamine-low basal diet, urinary and fecal thiamine excretion decreased, and the animals showed symptoms of thiamine deficiency; thus an inhibitory effect of sulfaguanidine on the intestinal synthesis of thiamine was indicated. This inhibitory effect...

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Published inThe Journal of nutrition Vol. 76; no. 3; pp. 265 - 270
Main Authors Meghal, S.K., Nath, M.C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.1962
Subjects
Acetates - pharmacology
Animals
Glucose - analogs & derivatives
Old Medline
Penicillins - pharmacology
Rats
Sulfaguanidine
Sulfanilamides
Sulfonamides - pharmacology
Thiamine - metabolism
GLUCOSE/related compounds
VITAMIN B 1/metabolism
SULFONAMIDES/pharmacology
ACETATES/pharmacology
PENICILLIN/pharmacology
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Abstract When rats were fed sulfaguanidine together with a thiamine-low basal diet, urinary and fecal thiamine excretion decreased, and the animals showed symptoms of thiamine deficiency; thus an inhibitory effect of sulfaguanidine on the intestinal synthesis of thiamine was indicated. This inhibitory effect could be overcome by feeding either penicillin or hydrolyzed glucose cycloacetoacetate. Rats thus fed showed an increase in the urinary and fecal excretion of thiamine, with a higher thiamine content in the liver. Inclusion of either penicillin or hydrolyzed glucose cycloacetoacetate promoted better growth with the use of thiamine-low diets. This observation indicates that both compounds enhanced the thiamine synthesis by the intestinal flora and caused an increase in fecal thiamine, which was ultimately available to the rats after coprophagy.
AbstractList When rats were fed sulfaguanidine together with a thiamine-low basal diet, urinary and fecal thiamine excretion decreased, and the animals showed symptoms of thiamine deficiency; thus an inhibitory effect of sulfaguanidine on the intestinal synthesis of thiamine was indicated. This inhibitory effect could be overcome by feeding either penicillin or hydrolyzed glucose cycloacetoacetate. Rats thus fed showed an increase in the urinary and fecal excretion of thiamine, with a higher thiamine content in the liver. Inclusion of either penicillin or hydrolyzed glucose cycloacetoacetate promoted better growth with the use of thiamine-low diets. This observation indicates that both compounds enhanced the thiamine synthesis by the intestinal flora and caused an increase in fecal thiamine, which was ultimately available to the rats after coprophagy.
Author Nath, M.C.
Meghal, S.K.
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10.1016/0003-9861(59)90398-4
10.1042/bj0430002
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10.1016/0003-9861(58)90241-8
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10.1093/jn/71.2.149
10.1042/bj0470024
10.1093/jn/14.3.273
10.1093/jn/57.1.61
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Säuberlich (10.1093/jn/76.3.265_bib25) 1952; 46
Barnes (10.1093/jn/76.3.265_bib4) 1960; 71
Nath (10.1093/jn/76.3.265_bib23) 1960; 14
Scott (10.1093/jn/76.3.265_bib28) 1957; 61
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Nath (10.1093/jn/76.3.265_bib20) 1957; 6
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Snippet When rats were fed sulfaguanidine together with a thiamine-low basal diet, urinary and fecal thiamine excretion decreased, and the animals showed symptoms of...
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SubjectTerms Acetates - pharmacology
Animals
Glucose - analogs & derivatives
Old Medline
Penicillins - pharmacology
Rats
Sulfaguanidine
Sulfanilamides
Sulfonamides - pharmacology
Thiamine - metabolism
Title Inhibitory Effect of Sulfaguanidine on the Biosynthesis of Thiamine in Rats and the Beneficial Role of Penicillin and Hydrolyzed Glucose Cycloacetoacetate
URI https://dx.doi.org/10.1093/jn/76.3.265
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