First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis

• Published in: Metabolomics Vol. 20; no. 2; p. 25
• Main Authors: Fall, Fanta, Mamede, Lucia, Vast, Madeline, De Tullio, Pascal, Hayette, Marie-Pierre, Michels, Paul A. M., Frédérich, Michel, Govaerts, Bernadette, Quetin-Leclercq, Joëlle
• Format: Journal Article Web Resource
• Language: English
• Published: New York Springer US 23.02.2024; Springer Nature B.V; Springer
• Subjects: African trypanosomiasis; Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Clinical Biochemistry; Developmental Biology; Endocrinology, Diabetes and Metabolism; Glycolysis; Human health sciences; Humans; Life Sciences; Liquid chromatography; Magnetic resonance spectroscopy; Mass spectrometry; Mass spectroscopy; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; Molecular Medicine; Multivariate analysis; NMR; Nuclear magnetic resonance; Original Article; Parasitic diseases; Pharmacie, pharmacologie & toxicologie; Pharmacy, pharmacology & toxicology; Principal components analysis; Protozoa; Sciences de la santé humaine; Statistical analysis; Suramin; Suramin - metabolism; Suramin - pharmacology; Suramin - therapeutic use; Tricarboxylic acid cycle; Trypanosoma brucei; Trypanosoma brucei brucei; Trypanosoma brucei brucei - metabolism; Trypanosomiasis, African; Trypanosomiasis, African - drug therapy; Trypanosomiasis, African - parasitology; Workflow; Metabolomics; Suramin; Nuclear magnetic resonance; Mass spectrometry; Trypanosoma brucei

Introduction Human African trypanosomiasis, commonly known as sleeping sickness, is a vector-borne parasitic disease prevalent in sub-Saharan Africa and transmitted by the tsetse fly. Suramin, a medication with a long history of clinical use, has demonstrated varied modes of action against Trypanoso...