Folic acid-modified methotrexate-conjugated gold nanoparticles as nano-sized trojans for drug delivery to folate receptor-positive cancer cells

• Published in: Nanotechnology Vol. 31; no. 35; pp. 355101 - 355113
• Main Authors: Yücel, O uz, engelen, Asl han, Emik, Serkan, Önay-Uçar, Evren, Arda, Nazl, Gürda, Gülten
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 28.08.2020
• Subjects: A549 Cells; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; cancer therapy; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Drug Synergism; folate receptor; Folic Acid - chemistry; Folic Acid - pharmacology; Glutathione - chemistry; Gold - chemistry; gold nanoparticles; HEK293 Cells; HeLa Cells; Humans; Metal Nanoparticles; methotrexate; Methotrexate - chemistry; Methotrexate - pharmacology; Particle Size; PC-3 Cells; targeted drug delivery

Methotrexate (MTX), an analog of folic acid (FA), is a drug widely used in cancer treatment. To prevent its potential toxicity and enhance therapeutic efficacy, targeted drug delivery systems, especially nanotechnology-folate platforms, are a central strategy. Gold nanoparticles (AuNPs) are promisin...