Effects of Tetramethylpyrazine on Cardiac Function and Mortality Rate in Septic Rats
Objective： To study the effects of tetramethylpyrazine （TMP） on cardiac function and mortality rate in septic rats. Methods： Fifty male Sprague-Dawley rats were randomized into a sham-operation group （sham group, n=10）, normal saline group （NS group, n=20）, and TMP group （n=20）. The rats in the NS a...
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| Published in | Chinese journal of integrative medicine Vol. 18; no. 8; pp. 610 - 615 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Chinese Association of Traditional and Western Medicine
01.08.2012
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-0415 1993-0402 1993-0402 |
| DOI | 10.1007/s11655-012-1175-y |
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| Abstract | Objective： To study the effects of tetramethylpyrazine （TMP） on cardiac function and mortality rate in septic rats. Methods： Fifty male Sprague-Dawley rats were randomized into a sham-operation group （sham group, n=10）, normal saline group （NS group, n=20）, and TMP group （n=20）. The rats in the NS and TMP groups underwent cecal ligation and puncture （CLP） to induce sepsis. Rats in the NS group were injected with NS （10 mL/kg） immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP （10 mg/kg） at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α （TNF-α） were also tested. The correlation between TNF-α and the ejection fraction （EF） was observed. Left ventricle specimens were reserved for histomorphologic study. Results： Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels （P〈0.05）. The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group （P〈0.05）. Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value （r=-0.583, P=0.000）. Conclusion： TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function. |
|---|---|
| AbstractList | Objective
To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats.
Methods
Fifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group,
n
=10), normal saline group (NS group,
n
=20), and TMP group (
n
=20). The rats in the NS and TMP groups underwent cecal ligation and puncture (CLP) to induce sepsis. Rats in the NS group were injected with NS (10 mL/kg) immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP (10 mg/kg) at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α (TNF-α) were also tested. The correlation between TNF-α and the ejection fraction (EF) was observed. Left ventricle specimens were reserved for histomorphologic study.
Results
Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels (
P
<0.05). The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group (
P
<0.05). Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value (
r
=−0.583,
P
=0.000).
Conclusion
TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function. To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats.OBJECTIVETo study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats.Fifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group, n=10), normal saline group (NS group, n=20), and TMP group (n=20). The rats in the NS and TMP groups underwent cecal ligation and puncture (CLP) to induce sepsis. Rats in the NS group were injected with NS (10 mL/kg) immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP (10 mg/kg) at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α (TNF-α) were also tested. The correlation between TNF-α and the ejection fraction (EF) was observed. Left ventricle specimens were reserved for histomorphologic study.METHODSFifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group, n=10), normal saline group (NS group, n=20), and TMP group (n=20). The rats in the NS and TMP groups underwent cecal ligation and puncture (CLP) to induce sepsis. Rats in the NS group were injected with NS (10 mL/kg) immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP (10 mg/kg) at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α (TNF-α) were also tested. The correlation between TNF-α and the ejection fraction (EF) was observed. Left ventricle specimens were reserved for histomorphologic study.Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels (P <0.05). The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group (P <0.05). Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value (r=-0.583,P=0.000).RESULTSCompared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels (P <0.05). The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group (P <0.05). Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value (r=-0.583,P=0.000).TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function.CONCLUSIONTMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function. To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats. Fifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group, n=10), normal saline group (NS group, n=20), and TMP group (n=20). The rats in the NS and TMP groups underwent cecal ligation and puncture (CLP) to induce sepsis. Rats in the NS group were injected with NS (10 mL/kg) immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP (10 mg/kg) at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α (TNF-α) were also tested. The correlation between TNF-α and the ejection fraction (EF) was observed. Left ventricle specimens were reserved for histomorphologic study. Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels (P <0.05). The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group (P <0.05). Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value (r=-0.583,P=0.000). TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function. Objective： To study the effects of tetramethylpyrazine （TMP） on cardiac function and mortality rate in septic rats. Methods： Fifty male Sprague-Dawley rats were randomized into a sham-operation group （sham group, n=10）, normal saline group （NS group, n=20）, and TMP group （n=20）. The rats in the NS and TMP groups underwent cecal ligation and puncture （CLP） to induce sepsis. Rats in the NS group were injected with NS （10 mL/kg） immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP （10 mg/kg） at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α （TNF-α） were also tested. The correlation between TNF-α and the ejection fraction （EF） was observed. Left ventricle specimens were reserved for histomorphologic study. Results： Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels （P〈0.05）. The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group （P〈0.05）. Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value （r=-0.583, P=0.000）. Conclusion： TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function. |
| Author | 郭力恒 杨澄 王磊 陈全福 胡亚南 张敏州 |
| AuthorAffiliation | Intensive Care Unit, Guangdong Province Hospital of Chinese Medicine, Guangzhou （510120）, China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22855036$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1155_2019_6791457 crossref_primary_10_1007_s11655_014_1751_4 crossref_primary_10_1042_BSR20170319 crossref_primary_10_1007_s11010_019_03650_4 |
| Cites_doi | 10.1097/01.CCM.0000284492.30800.00 10.1097/00003246-200107000-00002 10.1097/01.CCM.0000163398.79679.66 10.1056/NEJM199007263230405 10.1097/CCM.0b013e3181ce4e50 10.1038/nprot.2008.214 10.1023/A:1011446602717 10.1097/01.CCM.0000298158.12101.41 10.1161/CIRCULATIONAHA.106.678359 10.1152/ajpregu.1984.246.3.R331 10.2119/2007-00130.Flierl |
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| DocumentTitleAlternate | Effects of Tetramethylpyrazine on Cardiac Function and Mortality Rate in Septic Rats |
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| Keywords | tetramethylpyrazine cardiac function sepsis mortality rate |
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| Notes | GUO Li-heng , YANG Cheng , WANG Lei, CHEN Quan-fu, HU Ya-nan , and ZHANG Min-zhou （ Intensive Care Unit, Guangdong Province Hospital of Chinese Medicine, Guangzhou （510120）, China） 11-4928/R Objective： To study the effects of tetramethylpyrazine （TMP） on cardiac function and mortality rate in septic rats. Methods： Fifty male Sprague-Dawley rats were randomized into a sham-operation group （sham group, n=10）, normal saline group （NS group, n=20）, and TMP group （n=20）. The rats in the NS and TMP groups underwent cecal ligation and puncture （CLP） to induce sepsis. Rats in the NS group were injected with NS （10 mL/kg） immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP （10 mg/kg） at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α （TNF-α） were also tested. The correlation between TNF-α and the ejection fraction （EF） was observed. Left ventricle specimens were reserved for histomorphologic study. Results： Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels （P〈0.05）. The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group （P〈0.05）. Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value （r=-0.583, P=0.000）. Conclusion： TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function. tetramethylpyrazine, sepsis, cardiac function, mortality rate ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| Snippet | Objective： To study the effects of tetramethylpyrazine （TMP） on cardiac function and mortality rate in septic rats. Methods： Fifty male Sprague-Dawley rats... Objective To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats. Methods Fifty male Sprague-Dawley rats were... To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats. Fifty male Sprague-Dawley rats were randomized into a... To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats.OBJECTIVETo study the effects of tetramethylpyrazine... |
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| SubjectTerms | Animals Heart Function Tests - drug effects Male Medicine Medicine & Public Health Myocardium - pathology Myocardium - ultrastructure Original Article Pyrazines - pharmacology Pyrazines - therapeutic use Rats Rats, Sprague-Dawley Sepsis - blood Sepsis - diagnostic imaging Sepsis - drug therapy Sepsis - physiopathology Sprague-Dawley Stroke Volume - drug effects Survival Analysis Tumor Necrosis Factor-alpha - blood Ultrasonography 大鼠 川芎嗪 心功能 死亡率 生理盐水 组织形态学 脓毒症 |
| Title | Effects of Tetramethylpyrazine on Cardiac Function and Mortality Rate in Septic Rats |
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