Synthesis of functionalized 7-azaindoles via directed ortho-metalations

Graphic Functionalization at C-5 of 4-fluoro- and 4-chloro-1-triisopropylsilyl-7-azaindole, 1 and 2 , respectively, leads to a variety of new substituted 7-azaindole derivatives. We also describe two approaches to introduce functionality at C-6.

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 11; pp. 2317 - 2319
Main Authors L’Heureux, Alexandre, Thibault, Carl, Ruel, Réjean
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.03.2004
Elsevier
Subjects
7-Azaindole
Chemistry
Chemistry, Organic
ortho-Metalation
Physical Sciences
Science & Technology
7-Azaindole
ortho-Metalation
ortho-metalation
AROMATICS
7-azaindole
DERIVATIVES
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Summary:Graphic Functionalization at C-5 of 4-fluoro- and 4-chloro-1-triisopropylsilyl-7-azaindole, 1 and 2 , respectively, leads to a variety of new substituted 7-azaindole derivatives. We also describe two approaches to introduce functionality at C-6.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.01.122