T-bet Knockout Prevents Helicobacter felis-Induced Gastric Cancer

Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor of disease risk. Elevated TNF-alpha, IL-1beta, and low IL-10 are associated with the highest risk. In this study, we used C57BL/6 mice to identify T-b...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 183; no. 1; pp. 642 - 649
Main Authors Stoicov, Calin, Fan, Xueli, Liu, Jian Hua, Bowen, Glennice, Whary, Mark, Kurt-Jones, Evelyn, Houghton, JeanMarie
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.07.2009
Subjects
Adenocarcinoma - immunology
Adenocarcinoma - microbiology
Adenocarcinoma - prevention & control
Animals
Female
Gastric Mucosa - immunology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Genetic Predisposition to Disease
Helicobacter felis - immunology
Helicobacter Infections - immunology
Helicobacter Infections - pathology
Helicobacter Infections - prevention & control
Interleukin-1beta - physiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Stomach Neoplasms - immunology
Stomach Neoplasms - microbiology
Stomach Neoplasms - prevention & control
T-Box Domain Proteins - deficiency
T-Box Domain Proteins - genetics
T-Box Domain Proteins - physiology
Tumor Necrosis Factor-alpha - physiology
Online AccessGet full text

Cover

Abstract Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor of disease risk. Elevated TNF-alpha, IL-1beta, and low IL-10 are associated with the highest risk. In this study, we used C57BL/6 mice to identify T-bet as a central regulator of the cytokine environment during Helicobacter felis infection. We infected male and female C57BL/6 and C57BL/6-T-bet knockout (KO) litter mates with H. felis and examined the bacterial colonization, immune response, and mucosal damage at varying time points. T-bet KO mice maintained infection for 15 mo at similar levels to wild-type mice. Infection and immune response did not differ between male and female mice. Despite sustained infection, T-bet KO mice respond with a blunted Th1 response associated with preservation of parietal and chief cells and protection from the development of gastric cancer. Unexpectedly, T-bet KO mice develop a gastric environment that would not be expected based on the phenotype of T-bet KO CD4 cells alone. T-bet KO mice respond to H. felis infection with a markedly blunted IL-1beta and TNF-alpha and elevated IL-10 levels. Activity of this one master regulator modulates the expression of the key gastric mucosal cytokines associated with gastric cancer and may be a target for therapy to restore immune balance clinically in patients at risk for gastric cancer.
AbstractList Abstract Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor of disease risk. Elevated TNF-α, IL-1β, and low IL-10 are associated with the highest risk. In this study, we used C57BL/6 mice to identify T-bet as a central regulator of the cytokine environment during Helicobacter felis infection. We infected male and female C57BL/6 and C57BL/6-T-bet knockout (KO) liter mates with H. felis and examined the bacterial colonization, immune response, and mucosal damage at varying time points. T-bet KO mice maintained infection for 15 mo at similar levels to wild-type mice. Infection and immune response did not differ between male and female mice. Despite sustained infection, T-bet KO mice respond with a blunted Th1 response associated with preservation of parietal and chief cells and protection from the development of gastric cancer. Unexpectedly, T-bet KO mice develop a gastric environment that would not be expected based on the phenotype of T-bet KO CD4 cells alone. T-bet KO mice respond to H. felis infection with a markedly blunted IL-1β and TNF-α and elevated IL-10 levels. Activity of this one master regulator modulates the expression of the key gastric mucosal cytokines associated with gastric cancer and may be a target for therapy to restore immune balance clinically in patients at risk for gastric cancer.
Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor of disease risk. Elevated TNF-alpha, IL-1beta, and low IL-10 are associated with the highest risk. In this study, we used C57BL/6 mice to identify T-bet as a central regulator of the cytokine environment during Helicobacter felis infection. We infected male and female C57BL/6 and C57BL/6-T-bet knockout (KO) litter mates with H. felis and examined the bacterial colonization, immune response, and mucosal damage at varying time points. T-bet KO mice maintained infection for 15 mo at similar levels to wild-type mice. Infection and immune response did not differ between male and female mice. Despite sustained infection, T-bet KO mice respond with a blunted Th1 response associated with preservation of parietal and chief cells and protection from the development of gastric cancer. Unexpectedly, T-bet KO mice develop a gastric environment that would not be expected based on the phenotype of T-bet KO CD4 cells alone. T-bet KO mice respond to H. felis infection with a markedly blunted IL-1beta and TNF-alpha and elevated IL-10 levels. Activity of this one master regulator modulates the expression of the key gastric mucosal cytokines associated with gastric cancer and may be a target for therapy to restore immune balance clinically in patients at risk for gastric cancer.
Author Kurt-Jones, Evelyn
Liu, Jian Hua
Stoicov, Calin
Houghton, JeanMarie
Bowen, Glennice
Whary, Mark
Fan, Xueli
Author_xml – sequence: 1
  fullname: Stoicov, Calin
– sequence: 2
  fullname: Fan, Xueli
– sequence: 3
  fullname: Liu, Jian Hua
– sequence: 4
  fullname: Bowen, Glennice
– sequence: 5
  fullname: Whary, Mark
– sequence: 6
  fullname: Kurt-Jones, Evelyn
– sequence: 7
  fullname: Houghton, JeanMarie
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19535625$$D View this record in MEDLINE/PubMed
BookMark eNpFkL1PwzAUxC1URD9gZ0KZ2FKe49iJx6qCtqISDGW2HOeFpiRxsRMi_nuCKOr0dNLdvdNvSkaNbZCQWwrzGGL5cCjrumtsNQcJwCm9IBPKOYRCgBiRCUAUhTQRyZhMvT8AgIAoviJjKjnjIuITstiFGbbBc2PNh-3a4NXhFzatD9ZYlcZm2rTogmIQPtw0eWcwD1bat640wVI3Bt01uSx05fHmdGfk7elxt1yH25fVZrnYhoYl0IY5NVpoHg0DkkQCR8mxoJhGiaGMFbkEanJZAMtBZEwXEjBNCwTOMhyWRmxG7v96j85-duhbVZfeYFXpBm3nlUhiYCxlgxH-jMZZ7x0W6ujKWrtvRUH9YlP_2NQJ2xC5O3V3WY35OXDidH6-L9_3felQ-VpX1WCnqu97mjJFlYgj9gPuXHjV
CitedBy_id crossref_primary_10_1186_s12876_020_01331_x
crossref_primary_10_1007_s00262_012_1358_6
crossref_primary_10_1038_mi_2010_53
crossref_primary_10_1111_j_1523_5378_2011_00877_x
crossref_primary_10_4049_jimmunol_1101772
crossref_primary_10_1002_path_2933
crossref_primary_10_1080_17474124_2021_1845140
crossref_primary_10_1371_journal_pone_0087505
crossref_primary_10_3390_toxins8060187
crossref_primary_10_4049_jimmunol_1000749
crossref_primary_10_1111_j_1523_5378_2010_00780_x
crossref_primary_10_26508_lsa_202000967
crossref_primary_10_1016_j_micpath_2018_06_033
crossref_primary_10_3389_fimmu_2014_00116
crossref_primary_10_31146_1682_8658_ecg_221_1_21_30
crossref_primary_10_1111_j_1523_5378_2010_00777_x
crossref_primary_10_1016_j_mrrev_2010_03_001
crossref_primary_10_18632_aging_101848
crossref_primary_10_1111_j_1523_5378_2011_00861_x
crossref_primary_10_1053_j_gastro_2017_09_002
crossref_primary_10_1007_s00204_016_1747_2
crossref_primary_10_1172_jci_insight_94035
crossref_primary_10_1038_nrmicro3016
crossref_primary_10_1038_s41388_020_1241_4
Cites_doi 10.1002/ijc.2910410205
10.1007/s10120-001-8010-z
10.1016/S0016-5085(03)00157-4
10.3322/canjclin.49.1.8
10.1128/IAI.01887-05
10.1016/S0016-5085(00)70412-4
10.1086/315788
10.3892/or.10.1.57
10.1128/IAI.68.3.1189-1195.2000
10.1006/meth.2001.1262
10.1038/35006081
10.4049/jimmunol.162.7.4053
10.4049/jimmunol.166.12.7456
10.4049/jimmunol.173.5.3329
10.1177/1756283X08093567
10.1038/labinvest.3700260
10.1007/s10120-007-0420-0
10.1155/2001/850308
10.1073/pnas.96.19.10800
10.1128/IAI.73.10.6311-6321.2005
10.1034/j.1600-0463.2003.1110203.x
10.1016/j.ccr.2008.10.011
10.1158/1055-9965.EPI-06-0189
10.1016/S0016-5085(03)80094-X
10.1053/j.gastro.2005.02.066
10.1152/ajpgi.00267.2007
10.1016/S0016-5085(98)70581-5
10.1053/j.gastro.2007.06.026
10.1084/jem.20011956
10.1016/j.micinf.2005.05.017
10.1038/75015
10.1073/pnas.0700021104
10.1053/gast.2002.30298
10.1016/S0092-8674(00)80702-3
10.1128/AEM.01675-06
10.1002/1096-9896(2000)9999:9999<::AID-PATH759>3.0.CO;2-A
10.1128/IAI.68.8.4802-4804.2000
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.4049/jimmunol.0900511
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1550-6606
EndPage 649
ExternalDocumentID 10_4049_jimmunol_0900511
19535625
www183_1_642
Genre Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: R01 CA113564
GroupedDBID -
2WC
34G
39C
3O-
53G
55
5GY
5RE
5VS
79B
85S
8RP
AALRV
AARDX
ABEFU
ABFLS
ABOCM
ABPPZ
ABPTK
ACGFS
ACIWK
ACNCT
ACPRK
ADACO
ADBBV
ADKFC
AENEX
AETEA
AFFNX
AFRAH
AJYGW
ALMA_UNASSIGNED_HOLDINGS
BAWUL
D0L
DIK
DU5
E3Z
EBS
EJD
F5P
FH7
FRP
GX1
H13
IH2
K-O
K78
KQ8
L7B
MVM
O0-
OK1
P0W
P2P
PQEST
PQQKQ
R.V
RHF
RHI
RZQ
SJN
TWZ
WH7
WOQ
X
X7M
XJT
ZA5
ZE2
ZGI
---
-~X
.55
18M
ABCQX
ABJNI
ACGFO
ADNWM
AFHIN
AFOSN
AHWXS
AIZAD
BTFSW
CGR
CUY
CVF
ECM
EIF
NPM
TR2
W8F
XSW
XTH
YHG
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c370t-d1ca6a5202477905e95ef1e827c133fd901cd9f03d06b3af90e88fe053be62523
ISSN 0022-1767
IngestDate Sat Aug 17 01:15:39 EDT 2024
Thu Sep 26 17:18:50 EDT 2024
Sat Sep 28 07:54:53 EDT 2024
Tue Nov 10 19:20:43 EST 2020
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c370t-d1ca6a5202477905e95ef1e827c133fd901cd9f03d06b3af90e88fe053be62523
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://journals.aai.org/jimmunol/article-pdf/183/1/642/1318363/zim01309000642.pdf
PMID 19535625
PQID 67403383
PQPubID 23479
PageCount 8
ParticipantIDs proquest_miscellaneous_67403383
crossref_primary_10_4049_jimmunol_0900511
pubmed_primary_19535625
highwire_smallpub1_www183_1_642
ProviderPackageCode RHF
RHI
PublicationCentury 2000
PublicationDate 20090701
2009-Jul-01
2009-07-01
PublicationDateYYYYMMDD 2009-07-01
PublicationDate_xml – month: 07
  year: 2009
  text: 20090701
  day: 01
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle The Journal of immunology (1950)
PublicationTitleAlternate J Immunol
PublicationYear 2009
Publisher Am Assoc Immnol
Publisher_xml – name: Am Assoc Immnol
References 11781287 - Gastroenterology. 2002 Jan;122(1):119-33
10611152 - Gastroenterology. 2000 Jan;118(1):36-47
8658212 - Semin Oncol. 1996 Jun;23(3):281-91
3338870 - Int J Cancer. 1988 Feb 15;41(2):184-97
11390498 - J Immunol. 2001 Jun 15;166(12):7456-61
16177302 - Infect Immun. 2005 Oct;73(10):6311-21
10080136 - Dig Dis Sci. 1999 Mar;44(3):465-78
15940628 - Gastroenterology. 2005 Jun;128(7):1937-52
11180161 - J Pathol. 2001 Feb;193(2):162-8
17681184 - Gastroenterology. 2007 Aug;133(2):659-72
10678925 - Infect Immun. 2000 Mar;68(3):1189-95
15765119 - Lab Invest. 2005 May;85(5):702-15
16861655 - Infect Immun. 2006 Aug;74(8):4673-84
11846609 - Methods. 2001 Dec;25(4):402-8
9516388 - Gastroenterology. 1998 Apr;114(4):675-89
12469145 - Oncol Rep. 2003 Jan-Feb;10(1):57-63
12716387 - APMIS. 2003 Feb;111(2):309-14
10746728 - Nature. 2000 Mar 23;404(6776):398-402
10950781 - J Infect Dis. 2000 Sep;182(3):856-64
16985030 - Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1674-87
10761931 - Cell. 2000 Mar 17;100(6):655-69
10200775 - CA Cancer J Clin. 1999 Jan-Feb;49(1):8-31, 1
15322196 - J Immunol. 2004 Sep 1;173(5):3329-36
17991709 - Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G263-75
10201928 - J Immunol. 1999 Apr 1;162(7):4053-61
20953278 - Therap Adv Gastroenterol. 2008 Jul;1(1):19-31
10485906 - Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10800-5
16260169 - Microbes Infect. 2006 Jan;8(1):52-60
11846063 - Gastric Cancer. 2001;4(4):198-205
10899893 - Infect Immun. 2000 Aug;68(8):4802-4
18977329 - Cancer Cell. 2008 Nov 4;14(5):408-19
11493951 - Can J Gastroenterol. 2001 Jul;15(7):469-74
17142378 - Appl Environ Microbiol. 2007 Feb;73(3):1010-3
12730860 - Gastroenterology. 2003 May;124(5):1193-201
10802709 - Nat Med. 2000 May;6(5):536-42
17577615 - Gastric Cancer. 2007;10(2):75-83
17307869 - Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2827-30
11994418 - J Exp Med. 2002 May 6;195(9):1129-43
2023010203584845500_R11
2023010203584845500_R33
2023010203584845500_R10
2023010203584845500_R32
2023010203584845500_R31
2023010203584845500_R30
2023010203584845500_R15
2023010203584845500_R37
2023010203584845500_R14
2023010203584845500_R36
2023010203584845500_R13
2023010203584845500_R35
2023010203584845500_R12
2023010203584845500_R34
2023010203584845500_R29
2023010203584845500_R28
2023010203584845500_R27
2023010203584845500_R22
2023010203584845500_R21
2023010203584845500_R20
2023010203584845500_R26
2023010203584845500_R25
2023010203584845500_R24
2023010203584845500_R23
2023010203584845500_R19
2023010203584845500_R18
2023010203584845500_R17
2023010203584845500_R39
2023010203584845500_R16
2023010203584845500_R38
2023010203584845500_R2
2023010203584845500_R1
2023010203584845500_R4
2023010203584845500_R3
2023010203584845500_R6
2023010203584845500_R5
2023010203584845500_R8
2023010203584845500_R7
2023010203584845500_R9
References_xml – ident: 2023010203584845500_R1
  doi: 10.1002/ijc.2910410205
– ident: 2023010203584845500_R31
  doi: 10.1007/s10120-001-8010-z
– ident: 2023010203584845500_R6
  doi: 10.1016/S0016-5085(03)00157-4
– ident: 2023010203584845500_R2
  doi: 10.3322/canjclin.49.1.8
– ident: 2023010203584845500_R33
  doi: 10.1128/IAI.01887-05
– ident: 2023010203584845500_R17
  doi: 10.1016/S0016-5085(00)70412-4
– ident: 2023010203584845500_R19
  doi: 10.1086/315788
– ident: 2023010203584845500_R3
– ident: 2023010203584845500_R30
  doi: 10.3892/or.10.1.57
– ident: 2023010203584845500_R11
  doi: 10.1128/IAI.68.3.1189-1195.2000
– ident: 2023010203584845500_R18
  doi: 10.1006/meth.2001.1262
– ident: 2023010203584845500_R5
  doi: 10.1038/35006081
– ident: 2023010203584845500_R22
  doi: 10.4049/jimmunol.162.7.4053
– ident: 2023010203584845500_R8
  doi: 10.4049/jimmunol.166.12.7456
– ident: 2023010203584845500_R13
  doi: 10.4049/jimmunol.173.5.3329
– ident: 2023010203584845500_R35
  doi: 10.1177/1756283X08093567
– ident: 2023010203584845500_R21
  doi: 10.1038/labinvest.3700260
– ident: 2023010203584845500_R36
  doi: 10.1007/s10120-007-0420-0
– ident: 2023010203584845500_R4
  doi: 10.1155/2001/850308
– ident: 2023010203584845500_R20
– ident: 2023010203584845500_R23
  doi: 10.1073/pnas.96.19.10800
– ident: 2023010203584845500_R27
  doi: 10.1128/IAI.73.10.6311-6321.2005
– ident: 2023010203584845500_R29
  doi: 10.1034/j.1600-0463.2003.1110203.x
– ident: 2023010203584845500_R37
  doi: 10.1016/j.ccr.2008.10.011
– ident: 2023010203584845500_R39
  doi: 10.1158/1055-9965.EPI-06-0189
– ident: 2023010203584845500_R14
  doi: 10.1016/S0016-5085(03)80094-X
– ident: 2023010203584845500_R10
  doi: 10.1053/j.gastro.2005.02.066
– ident: 2023010203584845500_R28
  doi: 10.1152/ajpgi.00267.2007
– ident: 2023010203584845500_R9
  doi: 10.1016/S0016-5085(98)70581-5
– ident: 2023010203584845500_R12
  doi: 10.1053/j.gastro.2007.06.026
– ident: 2023010203584845500_R34
  doi: 10.1084/jem.20011956
– ident: 2023010203584845500_R38
  doi: 10.1016/j.micinf.2005.05.017
– ident: 2023010203584845500_R15
  doi: 10.1038/75015
– ident: 2023010203584845500_R24
  doi: 10.1073/pnas.0700021104
– ident: 2023010203584845500_R25
  doi: 10.1053/gast.2002.30298
– ident: 2023010203584845500_R16
  doi: 10.1016/S0092-8674(00)80702-3
– ident: 2023010203584845500_R26
  doi: 10.1128/AEM.01675-06
– ident: 2023010203584845500_R32
  doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH759>3.0.CO;2-A
– ident: 2023010203584845500_R7
  doi: 10.1128/IAI.68.8.4802-4804.2000
SSID ssj0006024
Score 2.1689582
Snippet Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor of...
Abstract Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor...
SourceID proquest
crossref
pubmed
highwire
SourceType Aggregation Database
Index Database
Publisher
StartPage 642
SubjectTerms Adenocarcinoma - immunology
Adenocarcinoma - microbiology
Adenocarcinoma - prevention & control
Animals
Female
Gastric Mucosa - immunology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Genetic Predisposition to Disease
Helicobacter felis - immunology
Helicobacter Infections - immunology
Helicobacter Infections - pathology
Helicobacter Infections - prevention & control
Interleukin-1beta - physiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Stomach Neoplasms - immunology
Stomach Neoplasms - microbiology
Stomach Neoplasms - prevention & control
T-Box Domain Proteins - deficiency
T-Box Domain Proteins - genetics
T-Box Domain Proteins - physiology
Tumor Necrosis Factor-alpha - physiology
Title T-bet Knockout Prevents Helicobacter felis-Induced Gastric Cancer
URI http://www.jimmunol.org/cgi/content/abstract/183/1/642
https://www.ncbi.nlm.nih.gov/pubmed/19535625
https://search.proquest.com/docview/67403383
Volume 183
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfKEGgXBOOrfOYAB1Slc2LHiY8wsVagcWGTeovi1JYmlRStySoQfzzvxXaSFSYxLlESRXbs99P78vsg5I0WidRa85ApXoRcIR8UYhkqpYzOUlNmGv2QJ1_E_Ix_WiSL0ejXMLukVtPy51_zSv6HqvAO6IpZsjegbDcovIB7oC9cgcJw_Tcah0rXk88V8DQML3blmDYoS4DAqi3EPDHwsJmE2KMDz_pnBXbqKCdHSO6LoW7aZ4nZQhKYOWIrNL1tz8HowGvwtV7DDJc2ZGR13iHs2PpTFw1M2sX6nDctVpCVzJveAbDeWpY3W2GEjUOYd0DILlh1mBAQpbarxlQ7PpqAVSqouMpo2R-IsmxT2ApbTgILW8R0l7lzMGaQubvlT6lEjhL1gswf3u_Ity7qEOwdHCP3I-RuhFvkdpzKBANCZ4s-QEjQmPta87g8e8iNIxzu_sNVpcYXmr7eaGmVl9P75J6javDeQugBGenqgNyxfUh_HJC7Jy7C4iH50GIq8JgKPKaCIaaCFlOBx1TgMBVYTD0iZ8cfT4_moeuzEZYspXW4jMpCFEkM68Xqk4mWiTaRzuK0jBgzS1AZy6U0lC2pUKwwkuosM9hTRGkwn2P2mOxV60o_JUHBMhNxJQ2jJS95JjOjBAhck4EcBcVoTN75jcq_23Iq-XVkGZPXfifzzbditYIdjPLtdgs4yqMcMANf-A3OgSviUVdR6XWzyUXKKTpfxuSJ3fd-NpkwNPqf3eBPnpP9HvgvyF590eiXoIvW6lULmd_yQIh-
link.rule.ids 315,786,790,27955,27956
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=T-bet+Knockout+Prevents+Helicobacter+felis+-Induced+Gastric+Cancer&rft.jtitle=The+Journal+of+immunology+%281950%29&rft.au=Stoicov%2C+Calin&rft.au=Fan%2C+Xueli&rft.au=Liu%2C+Jian+Hua&rft.au=Bowen%2C+Glennice&rft.date=2009-07-01&rft.issn=0022-1767&rft.eissn=1550-6606&rft.volume=183&rft.issue=1&rft.spage=642&rft.epage=649&rft_id=info:doi/10.4049%2Fjimmunol.0900511&rft.externalDBID=n%2Fa&rft.externalDocID=10_4049_jimmunol_0900511
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1767&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1767&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1767&client=summon