Transport of cephalosporins across artificial membranes and rabbit ileum

• Published in: International journal of pharmaceutics Vol. 145; no. 1; pp. 115 - 127
• Main Authors: Benkhelifa, Samir, Decroix, Maric-O., Arnaud, Philippe, Huneau, Jean-F., Tomé, Daniel, Chaumeil, Jean-C.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 06.12.1996; Elsevier
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Artificial membranes; Biological and medical sciences; Epithelial transport; Life Sciences; Medical sciences; Michaelis-Menten kinetic; Passive diffusion; pH-dependence; Pharmacology. Drug treatments; α-amino group; Passive diffusion; Epithelial transport; Michaelis-Menten kinetic; Artificial membranes; α-amino group; pH-dependence; Cefalexin; Digestive system; Biological transport; Gut; Rabbit; Artificial membrane; Biomembrane; Concentration; Lagomorpha; Ileum; In vitro; Vertebrata; Antibiotic; Cephalosporin derivatives; Mammalia; Animal; pH; Models; Kinetics; Cefadroxil; Antibacterial agent; Cefaclor; Transepithelial transport; TRANSPORT TRANS-EPITHELIAL

The aim of this study is to determine transepithelial transport of aminocephalosporins (cephalexin, cefaclor and cefadroxil) with in vitro models using artificial and biological membranes. The three antibiotics have higher partition coefficient ( K p) at pH 5 than at pH 6 and cephalexin passes throu...