Naloxone decreases the inhibitory effect of somatostatin on GH release induced by cigarette smoking in man
To establish whether somatostatin (SRIH) exerts its inhibitory effect on the nicotine-induced release of GH by interacting with an opioid pathway, normal volunteers were treated with naloxone during (2 no-filter) cigarettes smoking and with SRIH. Nicotine significantly increased serum GH levels abou...
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| Published in | Journal of Neural Transmission Vol. 118; no. 8; pp. 1173 - 1175 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
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Springer Vienna
01.08.2011
Springer Nature B.V |
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| Abstract | To establish whether somatostatin (SRIH) exerts its inhibitory effect on the nicotine-induced release of GH by interacting with an opioid pathway, normal volunteers were treated with naloxone during (2 no-filter) cigarettes smoking and with SRIH. Nicotine significantly increased serum GH levels about 3.5 fold. Naloxone alone did not change GH rise induced by cigarette smoking. The stimulatory effect of GH by nicotine was completely blocked by SRIH. In the presence of both SRIH and naloxone, GH levels rose 1.5 fold in response to nicotine. Since naloxone only partially reversed the inhibiting action of SRIH, only a partial involvement of opioid peptides in SRIH action might be supposed. Alternatively, SRIH and naloxone-sensitive opiates might produce this inhibiting effect on GH rise in response to cigarette smoking through independent pathways. |
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| AbstractList | To establish whether somatostatin (SRIH) exerts its inhibitory effect on the nicotine-induced release of GH by interacting with an opioid pathway, normal volunteers were treated with naloxone during (2 no-filter) cigarettes smoking and with SRIH. Nicotine significantly increased serum GH levels about 3.5 fold. Naloxone alone did not change GH rise induced by cigarette smoking. The stimulatory effect of GH by nicotine was completely blocked by SRIH. In the presence of both SRIH and naloxone, GH levels rose 1.5 fold in response to nicotine. Since naloxone only partially reversed the inhibiting action of SRIH, only a partial involvement of opioid peptides in SRIH action might be supposed. Alternatively, SRIH and naloxone-sensitive opiates might produce this inhibiting effect on GH rise in response to cigarette smoking through independent pathways. To establish whether somatostatin (SRIH) exerts its inhibitory effect on the nicotine-induced release of GH by interacting with an opioid pathway, normal volunteers were treated with naloxone during (2 no-filter) cigarettes smoking and with SRIH. Nicotine significantly increased serum GH levels about 3.5 fold. Naloxone alone did not change GH rise induced by cigarette smoking. The stimulatory effect of GH by nicotine was completely blocked by SRIH. In the presence of both SRIH and naloxone, GH levels rose 1.5 fold in response to nicotine. Since naloxone only partially reversed the inhibiting action of SRIH, only a partial involvement of opioid peptides in SRIH action might be supposed. Alternatively, SRIH and naloxone-sensitive opiates might produce this inhibiting effect on GH rise in response to cigarette smoking through independent pathways.[PUBLICATION ABSTRACT] |
| Author | Giumelli, Claudio Maccanelli, Francesco Araldi, Anna Stella, Adriano Coiro, Vittorio Volpi, Riccardo Chiodera, Paolo Cataldo, Simona |
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| References_xml | – volume: 78 start-page: 305 year: 1982 end-page: 308 ident: CR14 article-title: Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers publication-title: Psychopharmacology doi: 10.1007/BF00433730 contributor: fullname: Jarvik – volume: 30 start-page: 389 year: 1984 end-page: 393 ident: CR1 article-title: Coexistence of substances related to enkephalin and somatostatin in granules of the guinea-pig median eminence: demonstration by use of colloidal gold immunocytochemical methods publication-title: Brain Res doi: 10.1016/0006-8993(84)91110-7 contributor: fullname: Garaud – volume: 79 start-page: 511 year: 1999 end-page: 607 ident: CR12 article-title: Neuroendocrine control of growth hormone secretion publication-title: Physiol Rev contributor: fullname: Cocchi – volume: 115 start-page: 803 year: 2008 end-page: 807 ident: CR4 article-title: Effect of naloxone on somatostatin inhibition of 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| SubjectTerms | Adult Basic Neurosciences Genetics and Immunology - Rapid Communication Human Growth Hormone - antagonists & inhibitors Human Growth Hormone - blood Human Growth Hormone - secretion Humans Male Medicine Medicine & Public Health Naloxone - pharmacology Neurology Neurosciences Psychiatry Signal Transduction - drug effects Signal Transduction - physiology Smoking - blood Somatostatin - antagonists & inhibitors Somatostatin - pharmacology Young Adult |
| Title | Naloxone decreases the inhibitory effect of somatostatin on GH release induced by cigarette smoking in man |
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