Aminophenol-modified gold nanoparticles kill bacteria with minimal ototoxicity

• Published in: Chemical communications (Cambridge, England) Vol. 58; no. 17; pp. 2842 - 2845
• Main Authors: Wang, Le, Zheng, Wenfu, Zhong, Leni, Yang, Yingkun, Li, Sixiang, Li, Qizhen, Jiang, Xingyu
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 24.02.2022
• Subjects: Aminoglycosides; Aminophenol; Aminophenols - chemistry; Animals; antibacterial properties; Antiinfectives and antibacterials; Bacteria; Bacteria - drug effects; Cell Line; Cell Survival - drug effects; Dogs; Escherichia coli - drug effects; Gold; Gold - chemistry; Humans; Larva - drug effects; Larva - physiology; Metal Nanoparticles - chemistry; Metal Nanoparticles - toxicity; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Sensitivity Tests; multiple drug resistance; nanogold; Nanoparticles; ototoxicity; Zebrafish - growth & development

We report aminophenol (A)-modified gold nanoparticles (AGNPs), which have potent antibacterial effects against multidrug-resistant bacteria with a broad antibacterial spectrum. Moreover, a series of in vitro and in vivo models indicate that AGNPs are much less ototoxic than aminoglycosides. AGNPs th...