Hepatic toxicity and recovery of Fischer 344 rats following exposure to 2-aminoanthracene by intraperitoneal injection

• Published in: Toxicologic pathology Vol. 29; no. 3; p. 328
• Main Authors: Baker, D G, Taylor, H W, Lee, S P, Barker, S A, Goad, M E, Means, J C
• Format: Journal Article
• Language: English
• Published: United States 01.05.2001
• Subjects: Adenoma - chemically induced; Adenoma - pathology; Albumins - analysis; Alkaline Phosphatase - blood; Animals; Anthracenes - administration & dosage; Anthracenes - toxicity; Aspartate Aminotransferases - blood; Blood Proteins - analysis; Body Weight - drug effects; Carcinogens - administration & dosage; Carcinogens - toxicity; Disease-Free Survival; Focal Nodular Hyperplasia - chemically induced; Focal Nodular Hyperplasia - pathology; Globulins - analysis; Injections, Intraperitoneal; Liver - drug effects; Liver - pathology; Liver Neoplasms - chemically induced; Liver Neoplasms - pathology; Male; Mutagens - administration & dosage; Mutagens - toxicity; Rats; Rats, Inbred F344; Remission Induction; Weight Gain - drug effects

Humans may be exposed to 2-aminoanthracene (2-AA), a substituted polycyclic aromatic hydrocarbon, and a recognized mutagen and carcinogen, through oral and respiratory routes from contact with a variety of environmental sources. For the present study, we sought to evaluate hepatic damage and recover...