JUUL e-liquid exposure elicits cytoplasmic Ca2+ responses and leads to cytotoxicity in cultured airway epithelial cells

• Published in: Toxicology letters Vol. 337; pp. 46 - 56
• Main Authors: Zhang, Rui, Jones, Myles M., Dornsife, Ronna E., Wu, Tongde, Sivaraman, Vijay, Tarran, Robert, Onyenwoke, Rob U.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2021
• Subjects: Airway epithelial cells; Apoptosis; Calcium (Ca2+) signaling; Electronic cigarettes; Pro-inflammatory cytokines; Quantitative PCR (qPCR); Pro-inflammatory cytokines; Quantitative PCR (qPCR); Airway epithelial cells; Calcium (Ca2+) signaling; Electronic cigarettes; Apoptosis

[Display omitted] •JUUL e-liquids exhibit cytotoxicity when used to challenge cultured airway epithelial cells.•Exposure to JUUL “Mint” flavored e-liquid led to significant elevations in cytoplasmic Ca2+.•Upregulation of the cytokine IL-6 and early apoptotic marker Annexin V was evident after the “M...