Inspection time: a neuropsychophysiological test for measuring the functional integrity of the cholinergic system

Inspection time (IT) is a measure of the speed of early information processing, demonstrating reliable correlation with psychometric intelligence. We now provide evidence that it may serve as a marker for the integrity of the cholinergic system. Cholinergic agonists improve and antagonists impair IT...

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Published inMedical hypotheses Vol. 57; no. 6; pp. 759 - 760
Main Authors Nathan, P.J., Stough, C.
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.12.2001
Elsevier
Subjects
Alzheimer Disease - physiopathology
Alzheimer Disease - psychology
Biological and medical sciences
Biomarkers
Cholinergic Fibers - physiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Mental Processes - physiology
Nervous system
Neuropsychological Tests
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Time Factors
Tropical medicine
Human
Neuropsychological test
Inspection
Nervous system
Exploration
Time
Technique
Discussion
Cholinergic pathway
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Abstract Inspection time (IT) is a measure of the speed of early information processing, demonstrating reliable correlation with psychometric intelligence. We now provide evidence that it may serve as a marker for the integrity of the cholinergic system. Cholinergic agonists improve and antagonists impair IT, while modulators of the monoamine systems are without effect. Furthermore impairments in IT correlate with disease severity in Alzheimer's disease, a disorder of compromised cholinergic system function. Taken together, available data suggest that IT may be a useful physiological marker of functional status of the cholinergic system. Coptright 2001 Harcourt Publishers Ltd
AbstractList Inspection time (IT) is a measure of the speed of early information processing, demonstrating reliable correlation with psychometric intelligence. We now provide evidence that it may serve as a marker for the integrity of the cholinergic system. Cholinergic agonists improve and antagonists impair IT, while modulators of the monoamine systems are without effect. Furthermore impairments in IT correlate with disease severity in Alzheimer's disease, a disorder of compromised cholinergic system function. Taken together, available data suggest that IT may be a useful physiological marker of functional status of the cholinergic system. Coptright 2001 Harcourt Publishers Ltd
Inspection time (IT) is a measure of the speed of early information processing, demonstrating reliable correlation with psychometric intelligence. We now provide evidence that it may serve as a marker for the integrity of the cholinergic system. Cholinergic agonists improve and antagonists impair IT, while modulators of the monoamine systems are without effect. Furthermore impairments in IT correlate with disease severity in Alzheimer's disease, a disorder of compromised cholinergic system function. Taken together, available data suggest that IT may be a useful physiological marker of functional status of the cholinergic system.
Author Stough, C.
Nathan, P.J.
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Cites_doi 10.1016/0191-8869(90)90155-K
10.1007/s002130100753
10.1016/S0160-2896(89)80006-6
10.1093/brain/114.6.2543
10.1037/0003-066X.51.6.599
10.1007/s002130000409
10.1111/j.2044-8295.1996.tb02589.x
10.1007/BF02246296
10.1016/0191-8869(89)90220-1
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Keywords Human
Neuropsychological test
Inspection
Nervous system
Exploration
Time
Technique
Discussion
Cholinergic pathway
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Snippet Inspection time (IT) is a measure of the speed of early information processing, demonstrating reliable correlation with psychometric intelligence. We now...
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SubjectTerms Alzheimer Disease - physiopathology
Alzheimer Disease - psychology
Biological and medical sciences
Biomarkers
Cholinergic Fibers - physiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Mental Processes - physiology
Nervous system
Neuropsychological Tests
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Time Factors
Tropical medicine
Title Inspection time: a neuropsychophysiological test for measuring the functional integrity of the cholinergic system
URI https://dx.doi.org/10.1054/mehy.2001.1484
https://www.ncbi.nlm.nih.gov/pubmed/11918442
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