Design of a new DNA-polyintercalating drug, a bisacridinyl peptidic analogue of Triostin A

• Published in: Biochemical journal Vol. 225; no. 3; pp. 829 - 832
• Main Authors: Helbecque, N, Bernier, J L, Hénichart, J P
• Format: Journal Article
• Language: English
• Published: England 01.02.1985
• Subjects: Aminacrine; Chemical Phenomena; Chemistry; DNA; Intercalating Agents - chemical synthesis; Models, Chemical; Oligopeptides - chemical synthesis; Spectrophotometry

The synthesis of a new bifunctional compound in which two aminoacridine chromophores are linked by the bicyclic depsipeptidic backbone of des-N-tetramethylTriostin A is described. The molecule, bis-[(9-acridinyl)-D-seryl-L-alanyl-L-cysteinyl-L-valine] dilactone disulphide, structurally analogous to...