Mitochondrial permeability transition during hypothermic to normothermic reperfusion in rat liver demonstrated by the protective effect of cyclosporin A

• Published in: Biochemical journal Vol. 336 ( Pt 2); no. 2; pp. 501 - 506
• Main Authors: Leducq, N, Delmas-Beauvieux, M C, Bourdel-Marchasson, I, Dufour, S, Gallis, J L, Canioni, P, Diolez, P
• Format: Journal Article
• Language: English
• Published: England 01.12.1998
• Subjects: Animals; Cyclosporine - pharmacology; Energy Metabolism; Hypothermia - drug therapy; Hypothermia - metabolism; In Vitro Techniques; Intracellular Membranes; Ischemia - metabolism; Liver - blood supply; Liver - metabolism; Magnetic Resonance Spectroscopy; Male; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Oxidation-Reduction; Perfusion; Permeability; Phosphorus Isotopes; Phosphorylation; Protons; Rats; Rats, Wistar; Reperfusion

The purpose of this study was to test the hypothesis that mitochondrial permeability transition might be implicated in mitochondrial and intact organ dysfunctions associated with damage induced by reperfusion after cold ischaemia. Energetic metabolism was assessed continuously by 31P-NMR on a model...