Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones

Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [ 3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser...

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Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 81; no. 3; pp. 434 - 436
Main Authors Elford, Barry C., Roberts, Margaret F., Phillipson, J.David, Wilson, Robert J.M.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 1987
Royal Society of Tropical Medicine and Hygiene
Elsevier
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - pharmacology
Antiparasitic agents
Artemisia annua
Artemisinins
Biological and medical sciences
Clone Cells
Dose-Response Relationship, Drug
Drug Synergism
Flavonoids - pharmacology
Human protozoal diseases
Infectious diseases
Malaria
Medical sciences
Parasitic diseases
Pharmacology. Drug treatments
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Protozoal diseases
Sesquiterpenes - pharmacology
Tropical medicine
Potentiation
Antimalarial
Flavones
Radiolabelling
In vitro
Interaction
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Abstract Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [ 3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.
AbstractList Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.
Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [ 3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.
Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on ( super(3)H)hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum). Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua , from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.
Author Roberts, Margaret F.
Wilson, Robert J.M.
Elford, Barry C.
Phillipson, J.David
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  surname: Roberts
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  fullname: Wilson, Robert J.M.
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Issue 3
Keywords Potentiation
Antimalarial
Flavones
Radiolabelling
In vitro
Interaction
Language English
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Snippet Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth...
Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth...
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SubjectTerms Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - pharmacology
Antiparasitic agents
Artemisia annua
Artemisinins
Biological and medical sciences
Clone Cells
Dose-Response Relationship, Drug
Drug Synergism
Flavonoids - pharmacology
Human protozoal diseases
Infectious diseases
Malaria
Medical sciences
Parasitic diseases
Pharmacology. Drug treatments
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Protozoal diseases
Sesquiterpenes - pharmacology
Tropical medicine
Title Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones
URI https://dx.doi.org/10.1016/0035-9203(87)90161-1
https://api.istex.fr/ark:/67375/HXZ-HQNBQRVN-3/fulltext.pdf
https://www.ncbi.nlm.nih.gov/pubmed/3318019
https://search.proquest.com/docview/14858463
Volume 81
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