Fabrication and characterization of chitosan/gelatin porous scaffolds with predefined internal microstructures

• Published in: Polymer (Guilford) Vol. 48; no. 15; pp. 4578 - 4588
• Main Authors: Jiankang, He, Dichen, Li, Yaxiong, Liu, Bo, Yao, Bingheng, Lu, Qin, Lian
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 13.07.2007; Elsevier
• Subjects: Applied sciences; Biological and medical sciences; Chitosan/gelatin; Exact sciences and technology; Medical sciences; Natural polymers; Physicochemistry of polymers; Porous; Predefined channels; Proteins; Starch and polysaccharides; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Predefined channels; Porous; Chitosan/gelatin; Cell culture; Freeze drying; Tissue engineering; Liver; Wall thickness; In vitro; Porous material; Protein; Structure processing relationship; Pore size; Hepatocyte; Gelatin; Morphology; Crosslinked polymer; Oside polymer; Biomaterial; Chitosan; Manufacturing; Framework

The fabrication process for a novel three-dimensional (3D) chitosan/gelatin scaffold with predefined multilevel internal architectures and highly porous structures is presented combining solid freeform fabrication (SFF), microreplication and lyophilization techniques. The computer model of the scaff...