Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy

• Published in: AIDS (London) Vol. 28; no. 18; pp. 2677 - 2682
• Main Authors: Fabre-Mersseman, Véronique, Tubiana, Roland, Papagno, Laura, Bayard, Charles, Briceno, Olivia, Fastenackels, Solène, Dudoit, Yasmine, Rostane, Hafeda, Salmon, Dominique, Costagliola, Dominique, Caby, Fabienne, Sauce, Delphine, Viard, Jean-Paul, Appay, Victor
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 28.11.2014
• Subjects: Adult; Anti-Retroviral Agents - administration & dosage; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral Therapy, Highly Active - methods; Antiviral agents; B-Lymphocytes - immunology; Biological and medical sciences; CD8-Positive T-Lymphocytes - immunology; Cross-Sectional Studies; Female; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - pathology; HIV Infections - virology; HIV-1 - isolation & purification; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Immunophenotyping; Immunosuppressive Agents - administration & dosage; Infectious diseases; Lentivirus; Longitudinal Studies; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Retroviridae; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Vitamin D - administration & dosage; T lymphocytes; Immunopathology; Antiretroviral agent; Immunostimulation; immune activation; AIDS; Immune deficiency; Infection; Chemotherapy; Treatment; Vitamin D; Immunological investigation; Viral disease; T-Lymphocyte; Antiviral; HIV infection

A majority of HIV-1-infected patients present a severe deficit in vitamin D, which predicts short-term mortality. Vitamin D is a naturally synthesized hormone, with important immunomodulatory functions. In the general population, its deficit has been associated with increased markers of inflammation...