Valorisation of agricultural waste with an adsorption/nanofiltration hybrid process: from materials to sustainable process design
Downstream processing is considered to be the bottleneck in pharmaceutical manufacturing because its development has not kept pace with upstream production. In some cases, the lack of efficient downstream processing capacity can seriously affect both the sustainability and profitability of a pharmac...
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| Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 19; no. 13; pp. 3116 - 3125 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Downstream processing is considered to be the bottleneck in pharmaceutical manufacturing because its development has not kept pace with upstream production. In some cases, the lack of efficient downstream processing capacity can seriously affect both the sustainability and profitability of a pharmaceutical product and even result in its failure. Minimising solvent and raw material consumption, as well as utilising waste, can make a significant difference towards environmentally benign and economically viable chemical production. In this work, the authors present the development and modelling of a continuous adsorption process with in situ solvent recovery for the isolation of oleuropein from olive leaves, an agricultural waste. Waste utilisation in agriculture has gained increasing attention because this economic sector is ranked as the 2nd highest global greenhouse gas emission contributor. Imprinted polymers were developed for the selective scavenging of oleuropein from olive leaf extracts using green solvents. The mild temperature-swing (25-43 degree C) process allows the continuous isolation of oleuropein at 1.75 g product per kg of adsorbent per hour with an unprecedented 99.7% purity. In situ solvent recovery was realized with a solvent-resistant nanofiltration membrane allowing 97.5% solvent recycle and 44.5% total carbon footprint reduction, while concentrating both the product stream for crystallisation and the waste stream for disposal. |
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| AbstractList | Downstream processing is considered to be the bottleneck in pharmaceutical manufacturing because its development has not kept pace with upstream production. In some cases, the lack of efficient downstream processing capacity can seriously affect both the sustainability and profitability of a pharmaceutical product and even result in its failure. Minimising solvent and raw material consumption, as well as utilising waste, can make a significant difference towards environmentally benign and economically viable chemical production. In this work, the authors present the development and modelling of a continuous adsorption process with
in situ
solvent recovery for the isolation of oleuropein from olive leaves, an agricultural waste. Waste utilisation in agriculture has gained increasing attention because this economic sector is ranked as the 2
nd
highest global greenhouse gas emission contributor. Imprinted polymers were developed for the selective scavenging of oleuropein from olive leaf extracts using green solvents. The mild temperature-swing (25–43 °C) process allows the continuous isolation of oleuropein at 1.75 g product per kg of adsorbent per hour with an unprecedented 99.7% purity.
In situ
solvent recovery was realized with a solvent-resistant nanofiltration membrane allowing 97.5% solvent recycle and 44.5% total carbon footprint reduction, while concentrating both the product stream for crystallisation and the waste stream for disposal. Downstream processing is considered to be the bottleneck in pharmaceutical manufacturing because its development has not kept pace with upstream production. In some cases, the lack of efficient downstream processing capacity can seriously affect both the sustainability and profitability of a pharmaceutical product and even result in its failure. Minimising solvent and raw material consumption, as well as utilising waste, can make a significant difference towards environmentally benign and economically viable chemical production. In this work, the authors present the development and modelling of a continuous adsorption process with in situ solvent recovery for the isolation of oleuropein from olive leaves, an agricultural waste. Waste utilisation in agriculture has gained increasing attention because this economic sector is ranked as the 2nd highest global greenhouse gas emission contributor. Imprinted polymers were developed for the selective scavenging of oleuropein from olive leaf extracts using green solvents. The mild temperature-swing (25-43 degree C) process allows the continuous isolation of oleuropein at 1.75 g product per kg of adsorbent per hour with an unprecedented 99.7% purity. In situ solvent recovery was realized with a solvent-resistant nanofiltration membrane allowing 97.5% solvent recycle and 44.5% total carbon footprint reduction, while concentrating both the product stream for crystallisation and the waste stream for disposal. |
| Author | Fonte, Claudio P Didaskalou, Christos Kecili, Rustem Buyuktiryaki, Sibel Szekely, Gyorgy |
| Author_xml | – sequence: 1 givenname: Christos surname: Didaskalou fullname: Didaskalou, Christos – sequence: 2 givenname: Sibel surname: Buyuktiryaki fullname: Buyuktiryaki, Sibel – sequence: 3 givenname: Rustem surname: Kecili fullname: Kecili, Rustem – sequence: 4 givenname: Claudio surname: Fonte middlename: P fullname: Fonte, Claudio P – sequence: 5 givenname: Gyorgy surname: Szekely fullname: Szekely, Gyorgy |
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| Cites_doi | 10.1108/bij.2010.13117caa.001 10.1016/j.jclepro.2004.07.005 10.1039/c0gc00339e 10.1016/j.biortech.2007.11.064 10.1002/med.1028 10.1016/j.memsci.2011.06.043 10.1039/c0gc00918k 10.1016/j.seppur.2016.02.002 10.1021/op100327d 10.1039/C3GC41402G 10.1007/s00216-006-0419-0 10.1021/sc5004083 10.1021/op4002565 10.1016/j.supflu.2012.03.014 10.1039/C4GC01556H 10.1021/bm049478b 10.1039/C4GC00701H 10.1039/9781839168642 10.1039/c2gc16668b 10.1021/acsami.5b00755 10.1039/C6PY01853J 10.1039/C5GC01937K 10.1038/532435a 10.1016/j.chroma.2006.09.081 10.1002/jssc.201200784 10.3797/scipharm.0912-18 10.1055/s-0035-1568212 10.1016/j.memsci.2016.04.056 10.1016/j.chroma.2005.12.106 10.1021/op300108w 10.1016/j.cej.2010.01.007 10.1039/C6GC00611F 10.1039/C5GC01008J |
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| References | Koller (C7GC00912G-(cit11)/*[position()=1]) 2005; 6 Sholl (C7GC00912G-(cit25)/*[position()=1]) 2016; 532 Kupai (C7GC00912G-(cit43)/*[position()=1]) 2015; 7 Japón-Luján (C7GC00912G-(cit22)/*[position()=1]) 2006; 1108 Markarian (C7GC00912G-(cit5)/*[position()=1]) 2016; 40 Sarkis (C7GC00912G-(cit6)/*[position()=1]) 2010; 17 Kupai (C7GC00912G-(cit31)/*[position()=1]) 2017; 8 Göransson (C7GC00912G-(cit17)/*[position()=1]) 2016; 82 Edenhofer (C7GC00912G-(cit1)/*[position()=1]) 2014 Letcher (C7GC00912G-(cit7)/*[position()=1]) 2014 Bhatnagar (C7GC00912G-(cit10)/*[position()=1]) 2010; 157 Tilstam (C7GC00912G-(cit35)/*[position()=1]) 2012; 16 Sahin (C7GC00912G-(cit42)/*[position()=1]) 2012; 47 Japón-Luján (C7GC00912G-(cit23)/*[position()=1]) 2006; 385 Sud (C7GC00912G-(cit9)/*[position()=1]) 2008; 99 Kim (C7GC00912G-(cit29)/*[position()=1]) 2014; 2 Slater (C7GC00912G-(cit38)/*[position()=1]) 2010 Cheong (C7GC00912G-(cit33)/*[position()=1]) 2013; 36 Prat (C7GC00912G-(cit4)/*[position()=1]) 2013; 17 Nam (C7GC00912G-(cit13)/*[position()=1]) 2015; 17 Visioli (C7GC00912G-(cit16)/*[position()=1]) 2002; 22 Schaepertoens (C7GC00912G-(cit28)/*[position()=1]) 2016; 514 Xynos (C7GC00912G-(cit41)/*[position()=1]) 2012; 67 Mkaouara (C7GC00912G-(cit20)/*[position()=1]) 2016; 161 Japón-Luján (C7GC00912G-(cit19)/*[position()=1]) 2006; 1136 Szekely (C7GC00912G-(cit30)/*[position()=1]) 2014; 16 C7GC00912G-(cit37)/*[position()=1] Prat (C7GC00912G-(cit34)/*[position()=1]) 2016; 18 Henderson (C7GC00912G-(cit2)/*[position()=1]) 2011; 13 Drioli (C7GC00912G-(cit27)/*[position()=1]) 2012; 14 Jiménez-González (C7GC00912G-(cit39)/*[position()=1]) 2011; 15 Xie (C7GC00912G-(cit21)/*[position()=1]) 2015 Drioli (C7GC00912G-(cit26)/*[position()=1]) 2011; 380 Alder (C7GC00912G-(cit3)/*[position()=1]) 2016; 18 Omar (C7GC00912G-(cit15)/*[position()=1]) 2010; 78 Yusoff (C7GC00912G-(cit8)/*[position()=1]) 2006; 14 Kulkarni (C7GC00912G-(cit12)/*[position()=1]) 2010; 12 Kim (C7GC00912G-(cit24)/*[position()=1]) 2014; 16 Razali (C7GC00912G-(cit32)/*[position()=1]) 2015; 17 |
| References_xml | – start-page: 719485 year: 2015 ident: C7GC00912G-(cit21)/*[position()=1] publication-title: Adv. Mater. Sci. Eng. contributor: fullname: Xie – year: 2014 ident: C7GC00912G-(cit1)/*[position()=1] contributor: fullname: Edenhofer – volume: 17 start-page: 421 year: 2010 ident: C7GC00912G-(cit6)/*[position()=1] publication-title: Benchmarking Int. J. doi: 10.1108/bij.2010.13117caa.001 contributor: fullname: Sarkis – volume: 14 start-page: 87 year: 2006 ident: C7GC00912G-(cit8)/*[position()=1] publication-title: J. Cleaner. Prod. doi: 10.1016/j.jclepro.2004.07.005 contributor: fullname: Yusoff – volume: 12 start-page: 1990 year: 2010 ident: C7GC00912G-(cit12)/*[position()=1] publication-title: Green Chem. doi: 10.1039/c0gc00339e contributor: fullname: Kulkarni – volume: 99 start-page: 6017 year: 2008 ident: C7GC00912G-(cit9)/*[position()=1] publication-title: Bioresour. Technol. doi: 10.1016/j.biortech.2007.11.064 contributor: fullname: Sud – volume-title: Green Chemistry in the Pharmaceutical Industry year: 2010 ident: C7GC00912G-(cit38)/*[position()=1] contributor: fullname: Slater – volume: 22 start-page: 65 year: 2002 ident: C7GC00912G-(cit16)/*[position()=1] publication-title: Med. Res. Rev. doi: 10.1002/med.1028 contributor: fullname: Visioli – volume: 380 start-page: 1 year: 2011 ident: C7GC00912G-(cit26)/*[position()=1] publication-title: J. Membr. Sci. doi: 10.1016/j.memsci.2011.06.043 contributor: fullname: Drioli – volume: 13 start-page: 854 year: 2011 ident: C7GC00912G-(cit2)/*[position()=1] publication-title: Green Chem. doi: 10.1039/c0gc00918k contributor: fullname: Henderson – volume: 161 start-page: 165 year: 2016 ident: C7GC00912G-(cit20)/*[position()=1] publication-title: Sep. Purif. Technol. doi: 10.1016/j.seppur.2016.02.002 contributor: fullname: Mkaouara – volume: 15 start-page: 900 year: 2011 ident: C7GC00912G-(cit39)/*[position()=1] publication-title: Org. Process Res. Dev. doi: 10.1021/op100327d contributor: fullname: Jiménez-González – volume: 40 start-page: 36 year: 2016 ident: C7GC00912G-(cit5)/*[position()=1] publication-title: Pharm. Technol. contributor: fullname: Markarian – volume: 16 start-page: 133 year: 2014 ident: C7GC00912G-(cit24)/*[position()=1] publication-title: Green Chem. doi: 10.1039/C3GC41402G contributor: fullname: Kim – volume: 385 start-page: 753 year: 2006 ident: C7GC00912G-(cit23)/*[position()=1] publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-006-0419-0 contributor: fullname: Japón-Luján – volume: 2 start-page: 2371 year: 2014 ident: C7GC00912G-(cit29)/*[position()=1] publication-title: ACS Sustainable Chem. Eng. doi: 10.1021/sc5004083 contributor: fullname: Kim – volume: 17 start-page: 1517 year: 2013 ident: C7GC00912G-(cit4)/*[position()=1] publication-title: Org. Process Res. Dev. doi: 10.1021/op4002565 contributor: fullname: Prat – volume: 67 start-page: 89 year: 2012 ident: C7GC00912G-(cit41)/*[position()=1] publication-title: J. Supercrit. Fluids doi: 10.1016/j.supflu.2012.03.014 contributor: fullname: Xynos – volume: 17 start-page: 1718 year: 2015 ident: C7GC00912G-(cit13)/*[position()=1] publication-title: Green Chem. doi: 10.1039/C4GC01556H contributor: fullname: Nam – volume: 6 start-page: 561 year: 2005 ident: C7GC00912G-(cit11)/*[position()=1] publication-title: Biomacromolecules doi: 10.1021/bm049478b contributor: fullname: Koller – volume: 16 start-page: 4440 year: 2014 ident: C7GC00912G-(cit30)/*[position()=1] publication-title: Green Chem. doi: 10.1039/C4GC00701H contributor: fullname: Szekely – volume-title: Chemical Processes for a Sustainable Future year: 2014 ident: C7GC00912G-(cit7)/*[position()=1] doi: 10.1039/9781839168642 contributor: fullname: Letcher – volume: 14 start-page: 1561 year: 2012 ident: C7GC00912G-(cit27)/*[position()=1] publication-title: Green Chem. doi: 10.1039/c2gc16668b contributor: fullname: Drioli – volume: 7 start-page: 9516 year: 2015 ident: C7GC00912G-(cit43)/*[position()=1] publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.5b00755 contributor: fullname: Kupai – volume: 8 start-page: 666 year: 2017 ident: C7GC00912G-(cit31)/*[position()=1] publication-title: Polym. Chem. doi: 10.1039/C6PY01853J contributor: fullname: Kupai – ident: C7GC00912G-(cit37)/*[position()=1] – volume: 17 start-page: 5196 year: 2015 ident: C7GC00912G-(cit32)/*[position()=1] publication-title: Green Chem. doi: 10.1039/C5GC01937K contributor: fullname: Razali – volume: 532 start-page: 435 year: 2016 ident: C7GC00912G-(cit25)/*[position()=1] publication-title: Nature doi: 10.1038/532435a contributor: fullname: Sholl – volume: 1136 start-page: 185 year: 2006 ident: C7GC00912G-(cit19)/*[position()=1] publication-title: J. Chromatogr., A doi: 10.1016/j.chroma.2006.09.081 contributor: fullname: Japón-Luján – volume: 36 start-page: 609 year: 2013 ident: C7GC00912G-(cit33)/*[position()=1] publication-title: J. Sep. Sci. doi: 10.1002/jssc.201200784 contributor: fullname: Cheong – volume: 47 start-page: 2391 year: 2012 ident: C7GC00912G-(cit42)/*[position()=1] publication-title: Sep. Sci. Technol. contributor: fullname: Sahin – volume: 78 start-page: 133 year: 2010 ident: C7GC00912G-(cit15)/*[position()=1] publication-title: Sci. Pharm. doi: 10.3797/scipharm.0912-18 contributor: fullname: Omar – volume: 82 start-page: S1 year: 2016 ident: C7GC00912G-(cit17)/*[position()=1] publication-title: Planta Med. doi: 10.1055/s-0035-1568212 contributor: fullname: Göransson – volume: 514 start-page: 646 year: 2016 ident: C7GC00912G-(cit28)/*[position()=1] publication-title: J. Membr. Sci. doi: 10.1016/j.memsci.2016.04.056 contributor: fullname: Schaepertoens – volume: 1108 start-page: 76 year: 2006 ident: C7GC00912G-(cit22)/*[position()=1] publication-title: J. Chromatogr., A doi: 10.1016/j.chroma.2005.12.106 contributor: fullname: Japón-Luján – volume: 16 start-page: 1273 year: 2012 ident: C7GC00912G-(cit35)/*[position()=1] publication-title: Org. Process Res. Dev. doi: 10.1021/op300108w contributor: fullname: Tilstam – volume: 157 start-page: 277 year: 2010 ident: C7GC00912G-(cit10)/*[position()=1] publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2010.01.007 contributor: fullname: Bhatnagar – volume: 18 start-page: 3879 year: 2016 ident: C7GC00912G-(cit3)/*[position()=1] publication-title: Green Chem. doi: 10.1039/C6GC00611F contributor: fullname: Alder – volume: 18 start-page: 288 year: 2016 ident: C7GC00912G-(cit34)/*[position()=1] publication-title: Green Chem. doi: 10.1039/C5GC01008J contributor: fullname: Prat |
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| SubjectTerms | Economics Nanofiltration Olea Oleuropein Olives Pharmaceuticals Recovering Solvents Sustainability |
| Title | Valorisation of agricultural waste with an adsorption/nanofiltration hybrid process: from materials to sustainable process design |
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| Volume | 19 |
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| linkProvider | Royal Society of Chemistry |
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