Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

• Published in: Clinical cancer research Vol. 11; no. 6; pp. 2188 - 2194
• Main Authors: SEGAWA, Tomoya, SHOZU, Makio, MURAKAMI, Kouich, KASAI, Tadayuki, SHINOHARA, Kazunori, NOMURA, Kazuhito, OHNO, Satoshi, INOUE, Masaki
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.03.2005
• Subjects: Antineoplastic agents; Aromatase - genetics; Aromatase - metabolism; Biological and medical sciences; Carcinoma, Endometrioid - diagnosis; Carcinoma, Endometrioid - enzymology; Disease Progression; Endometrium - enzymology; Epithelial Cells - enzymology; Epithelial Cells - pathology; Estrogen formation; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; hybridization; immunohistochemistry; in situ; In Situ Hybridization; Lymphatic Metastasis - pathology; Medical sciences; Middle Aged; Myometrium - enzymology; Myometrium - pathology; Neoplasm Invasiveness - pathology; Pharmacology. Drug treatments; Prognosis; prognostic indicators; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stromal Cells - enzymology; survival analysis; Survival Rate; Tumors; Endometrium cancer; Enzyme; Uterine diseases; Stromal cell; Estrogen synthase; Malignant tumor; Gene expression; Survival; Female genital diseases

Purpose and Experimental Design: To assess the prognostic significance of intratumoral aromatase in endometrioid endometrial cancer, sections from 55 patients with endometrial cancer were evaluated for expression of aromatase using immunohistochemistry, and the correlation between aromatase expressi...