Modeling Repeated Measures with Monotonic Ordinal Responses and Misclassification, with Applications to Studying Maturation
Many longitudinal studies of children are concerned with the modeling of monotonic responses such as growth and sexual maturation. The National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) is a longitudinal study designed to examine the effect of growth and maturation on the devel...
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Published in | Journal of the American Statistical Association Vol. 92; no. 440; pp. 1304 - 1211 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Alexandria, VA
Taylor & Francis Group
01.12.1997
American Statistical Association Taylor & Francis Ltd |
Subjects | |
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Abstract | Many longitudinal studies of children are concerned with the modeling of monotonic responses such as growth and sexual maturation. The National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) is a longitudinal study designed to examine the effect of growth and maturation on the development of obesity and related cardiovascular risk factors among black and white adolescent girls. Sexual maturation is measured with an ordinal outcome and is known to be measured with sizable diagnostic error. Of interest is examining the effects of race and age on the sexual maturation process. Here we propose a class of models for analyzing repeated monotonic ordinal responses with diagnostic misclassification in which we separately model the underlying monotonic response and misclassification processes. We develop an EM algorithm for maximum likelihood estimation that incorporates covariates and randomly missing data. We use the method to analyze the NGHS sexual maturation data. |
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AbstractList | Albert et al develop an EM algorithm for maximum likelihood estimation that incorporates covariates and randomly missing data. Many longitudinal studies of children are concerned with the modeling of monotonic responses such as growth and sexual maturation. The National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) is a longitudinal study designed to examine the effect of growth and maturation on the development of obesity and related cardiovascular risk factors among black and white adolescent girls. Sexual maturation is measured with an ordinal outcome and is known to be measured with sizable diagnostic error. Of interest is examining the effects of race and age on the sexual maturation process. Here we propose a class of models for analyzing repeated monotonic ordinal responses with diagnostic misclassification in which we separately model the underlying monotonic response and misclassification processes. We develop an EM algorithm for maximum likelihood estimation that incorporates covariates and randomly missing data. We use the method to analyze the NGHS sexual maturation data. |
Author | Albert, Paul S. Biro, Frank M. Hunsberger, Sally A. |
Author_xml | – sequence: 1 givenname: Paul S. surname: Albert fullname: Albert, Paul S. organization: Office of Biostatistics Research National Heart and Blood Institute – sequence: 2 givenname: Sally A. surname: Hunsberger fullname: Hunsberger, Sally A. organization: Office of Biostatistics Research National Heart and Blood Institute – sequence: 3 givenname: Frank M. surname: Biro fullname: Biro, Frank M. organization: Clinical Pediatrics , University of Cincinnati |
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Cites_doi | 10.1080/01621459.1989.10478861 10.1111/j.1651-2227.1976.tb14766.x 10.1080/03610928608829324 10.1080/01621459.1985.10478195 10.1136/adc.44.235.291 10.1111/j.2517-6161.1980.tb01109.x 10.1214/aoms/1177705136 10.1002/ajhb.1310020506 10.2307/2533196 10.2307/2986089 10.1111/j.2517-6161.1977.tb01600.x 10.1080/01621459.1996.10476948 10.2307/2532193 10.1214/aoms/1177697196 10.1177/0049124186015001009 10.1007/978-1-4899-3242-6 10.2105/AJPH.82.12.1613 |
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SubjectTerms | Adolescents Algorithms Applications Applications and Case Studies Biology, psychology, social sciences Black people Children Diagnostic error EM algorithm Estimation bias Exact sciences and technology Insurance, economics, finance Longitudinal data Markov chains Markov mixture models Markov models Mathematical models Mathematics Medical sciences Missing data Modeling Modelling Multivariate analysis P values Parametric models Probabilities Probability and statistics Reliability, life testing, quality control Sciences and techniques of general use Statistical analysis Statistics Studies Tanneries Transition probabilities |
Title | Modeling Repeated Measures with Monotonic Ordinal Responses and Misclassification, with Applications to Studying Maturation |
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