Clusterin levels in undernourished SH-SY5Y cells
Food-related disorders are increasingly common in developed societies, and the psychological component of these disorders has been gaining increasing attention. Both overnourishment with high-fat diets and perinatal undernourishment in mice have been linked to a higher motivation toward food, result...
Saved in:
Published in | Food & nutrition research Vol. 65; pp. 1 - 7 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Sweden
Open Academia
04.05.2021
Swedish Nutrition Foundation |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Food-related disorders are increasingly common in developed societies, and the psychological component of these disorders has been gaining increasing attention. Both overnourishment with high-fat diets and perinatal undernourishment in mice have been linked to a higher motivation toward food, resulting in an alteration in food intake. Clusterin (CLU), a multifaced protein, is overexpressed in the
(NAc) of over-fed rats, as well as in those that suffered chronic undernutrition. Moreover, an increase of this protein was observed in the plasma of obese patients with food addiction, suggesting the implication of CLU in this eating disorder. To characterize CLU's cellular mechanisms,
experiments of undernutrition were performed using dopaminergic SH-SY5Y cells. To mimic
dietary conditions, cells were treated with different fetal bovine serum (FBS) concentrations, resulting in control (C group) diet (10% FBS), undernourishment (U group) diet (0.5% FBS), and undernourishment diet followed by restoration of control diet (UC group) (0.5 + 10% FBS). Undernourishment compromised cell viability and proliferation, and concomitantly increased CLU secretion as well as the cytosolic pool of the protein, while decreasing the mitochondrial level. The restoration of normal conditions tended to recover cell physiology, and the normal levels and distribution of CLU. This research study is a step forward toward the characterization of clusterin as a potential marker for food addiction and nutritional status. |
---|---|
AbstractList | Food-related disorders are increasingly common in developed societies, and the psychological component of these disorders has been gaining increasing attention. Both overnourishment with high-fat diets and perinatal undernourishment in mice have been linked to a higher motivation toward food, resulting in an alteration in food intake. Clusterin (CLU), a multifaced protein, is overexpressed in the
(NAc) of over-fed rats, as well as in those that suffered chronic undernutrition. Moreover, an increase of this protein was observed in the plasma of obese patients with food addiction, suggesting the implication of CLU in this eating disorder. To characterize CLU's cellular mechanisms,
experiments of undernutrition were performed using dopaminergic SH-SY5Y cells. To mimic
dietary conditions, cells were treated with different fetal bovine serum (FBS) concentrations, resulting in control (C group) diet (10% FBS), undernourishment (U group) diet (0.5% FBS), and undernourishment diet followed by restoration of control diet (UC group) (0.5 + 10% FBS). Undernourishment compromised cell viability and proliferation, and concomitantly increased CLU secretion as well as the cytosolic pool of the protein, while decreasing the mitochondrial level. The restoration of normal conditions tended to recover cell physiology, and the normal levels and distribution of CLU. This research study is a step forward toward the characterization of clusterin as a potential marker for food addiction and nutritional status. Food-related disorders are increasingly common in developed societies, and the psychological component of these disorders has been gaining increasing attention. Both overnourishment with high-fat diets and perinatal undernourishment in mice have been linked to a higher motivation toward food, resulting in an alteration in food intake. Clusterin (CLU), a multifaced protein, is overexpressed in the nucleus accumbens (NAc) of over-fed rats, as well as in those that suffered chronic undernutrition. Moreover, an increase of this protein was observed in the plasma of obese patients with food addiction, suggesting the implication of CLU in this eating disorder. To characterize CLU’s cellular mechanisms, in vitro experiments of undernutrition were performed using dopaminergic SH-SY5Y cells. To mimic in vivo dietary conditions, cells were treated with different fetal bovine serum (FBS) concentrations, resulting in control (C group) diet (10% FBS), undernourishment (U group) diet (0.5% FBS), and undernourishment diet followed by restoration of control diet (UC group) (0.5 + 10% FBS). Undernourishment compromised cell viability and proliferation, and concomitantly increased CLU secretion as well as the cytosolic pool of the protein, while decreasing the mitochondrial level. The restoration of normal conditions tended to recover cell physiology, and the normal levels and distribution of CLU. This research study is a step forward toward the characterization of clusterin as a potential marker for food addiction and nutritional status. Food-related disorders are increasingly common in developed societies, and the psychological component of these disorders has been gaining increasing attention. Both overnourishment with high-fat diets and perinatal undernourishment in mice have been linked to a higher motivation toward food, resulting in an alteration in food intake. Clusterin (CLU), a multifaced protein, is overexpressed in the nucleus accumbens (NAc) of over-fed rats, as well as in those that suffered chronic undernutrition. Moreover, an increase of this protein was observed in the plasma of obese patients with food addiction, suggesting the implication of CLU in this eating disorder. To characterize CLU’s cellular mechanisms, in vitro experiments of undernutrition were performed using dopaminergic SH-SY5Y cells. To mimic in vivo dietary conditions, cells were treated with different fetal bovine serum (FBS) concentrations, resulting in control (C group) diet (10% FBS), undernourishment (U group) diet (0.5% FBS), and undernourishment diet followed by restoration of control diet (UC group) (0.5 + 10% FBS). Undernourishment compromised cell viability and proliferation, and concomitantly increased CLU secretion as well as the cytosolic pool of the protein, while decreasing the mitochondrial level. The restoration of normal conditions tended to recover cell physiology, and the normal levels and distribution of CLU. This research study is a step forward toward the characterization of clusterin as a potential marker for food addiction and nutritional status. |
Author | González-Martín, Carmen Pérez-Carrión, María Dolores Rodríguez-Rivera, Carmen Mora, María José Polanco Olavarría, Lucía Casariego Alguacil, Luis F |
Author_xml | – sequence: 1 givenname: Carmen surname: Rodríguez-Rivera fullname: Rodríguez-Rivera, Carmen organization: Facultad de Farmacia, Universidad CEU San Pablo, Alcorcón, Madrid, Spain – sequence: 2 givenname: María Dolores surname: Pérez-Carrión fullname: Pérez-Carrión, María Dolores organization: Facultad de Medicina, Universidad de Castilla-la Mancha, Albacete, Spain – sequence: 3 givenname: Lucía Casariego surname: Olavarría fullname: Olavarría, Lucía Casariego organization: Facultad de Farmacia, Universidad CEU San Pablo, Alcorcón, Madrid, Spain – sequence: 4 givenname: Luis F surname: Alguacil fullname: Alguacil, Luis F organization: Facultad de Farmacia, Instituto de Estudio de las Adicciones, Universidad CEU San Pablo, Alcorcón, Madrid, Spain – sequence: 5 givenname: María José Polanco surname: Mora fullname: Mora, María José Polanco organization: Facultad de Farmacia, Instituto de Estudio de las Adicciones, Universidad CEU San Pablo, Alcorcón, Madrid, Spain – sequence: 6 givenname: Carmen surname: González-Martín fullname: González-Martín, Carmen organization: Facultad de Farmacia, Instituto de Estudio de las Adicciones, Universidad CEU San Pablo, Alcorcón, Madrid, Spain |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33994910$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkcFP2zAUhy0EosB23HXqcZd0L078bF8mTdUYlZB2ACQ4WY7zUlKlNrOTSvvvcSlDcPKT30_fz_J3zo598MTYlxIWXPNSf-98XOxQLIQEfcTOShR1gVjeH7-bZ-w8pQ0AVqDqUzarKq1rXcIZg-UwpZFi7-cD7WhI8zxNvqXowxT79Ejt_OaquHkQD3NHw5A-sZPODok-v54X7O7y1-3yqrj-83u1_HlduErCWCgpqOYlgqW6cQgcGlSddR3nDXKZVzVAx1Eq4lxoJTVwrtoWO2gVllRdsNWB2wa7MU-x39r4zwTbm5eLENfGxrF3AxnbcO2cBUFNBoNs0KFFlLnbci1kZv04sJ6mZkutIz9GO3yAftz4_tGsw84o0AprlQHfXgEx_J0ojWbbp_13WE9hSoYLrupKVHrfVRyiLoaUInVvNSWYF2MmGzPZmNkby_mv79_2lv6vqHoGi5OS0Q |
Cites_doi | 10.1038/onc.2012.212 10.1159/000366365 10.1074/jbc.M204855200 10.1016/S0140-6736(00)03643-6 10.15252/embr.201338317 10.1016/S1053-8119(03)00253-2 10.1016/j.neuroimage.2008.06.002 10.1016/j.eatbeh.2013.01.002 10.1016/j.coph.2007.10.011 10.1186/s40478-017-0481-1 10.1124/pr.110.002642 10.1007/s40273-014-0243-x 10.1080/02791072.2012.662092 10.1016/j.yfrne.2012.01.002 10.1515/bmc-2015-0026 10.1210/en.2004-0032 10.1074/jbc.274.11.6875 10.1038/ncb1291 10.1002/pro.5560061007 10.1007/s00018-011-0684-8 10.1016/j.mad.2019.01.002 10.1016/S0306-4522(98)00334-0 10.1083/jcb.105.6.2735 10.1111/j.1600-0854.2007.00549.x 10.1158/1078-0432.CCR-08-1805 10.1016/j.ijdevneu.2016.01.004 10.1007/s00268-018-4851-z 10.1007/s11011-012-9358-y 10.1021/pr2005555 10.1016/j.eplepsyres.2011.12.002 10.1016/j.ijdevneu.2013.05.001 10.1016/j.neuroscience.2010.04.010 10.1080/15216540310001640498 10.1038/ncomms2896 10.1242/jcs.00619 10.1176/ajp.2007.164.5.708 10.1016/j.pbb.2015.04.008 |
ContentType | Journal Article |
Copyright | 2021 Carmen Rodríguez Rivera et al. 2021 Carmen Rodríguez Rivera et al. 2021 |
Copyright_xml | – notice: 2021 Carmen Rodríguez Rivera et al. – notice: 2021 Carmen Rodríguez Rivera et al. 2021 |
DBID | NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.29219/fnr.v65.5709 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Public Health |
EISSN | 1654-661X |
EndPage | 7 |
ExternalDocumentID | oai_doaj_org_article_ab29cca05eb74207b6c6a6670aea2957 10_29219_fnr_v65_5709 33994910 |
Genre | Journal Article |
GroupedDBID | 0YH 29H 2QV 2WC 36B 53G 5GY 5VS 6PF 7RV 7X2 7X7 8FE 8FH 8FI 8FJ 8WT A8Z AABWD AAFWJ AAWTL ABDBF ABUWG ACGFS ADBBV ADRAZ AENEX AFKRA AFPKN ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ATCPS B0M BAWUL BCNDV BENPR BHPHI BKEYQ BPHCQ BVXVI C1A CCPQU DIK DXH E3Z EAD EAP EBC EBD EBS ECGQY EJD EMK EPL ESTFP ESX FYUFA GROUPED_DOAJ H13 HCIFZ HMCUK HYE KQ8 M0K M48 M4Z M~E NAPCQ NPM O5R O5S OK1 P2P PIMPY PQQKQ PROAC QF4 QN7 RPM TDBHL TFW TR2 TUS UKHRP ~8M AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c370t-875e42160ae4bc6020b68facf22b627421400f2678e22598790228dd6f0d861e3 |
IEDL.DBID | RPM |
ISSN | 1654-661X |
IngestDate | Tue Oct 22 15:13:16 EDT 2024 Tue Sep 17 21:21:53 EDT 2024 Fri Oct 25 04:45:56 EDT 2024 Fri Dec 06 01:16:34 EST 2024 Sat Sep 28 08:24:44 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | clusterin cell survival food addiction mitochondria undernutrition |
Language | English |
License | 2021 Carmen Rodríguez Rivera et al. https://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c370t-875e42160ae4bc6020b68facf22b627421400f2678e22598790228dd6f0d861e3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098648/ |
PMID | 33994910 |
PQID | 2528435397 |
PQPubID | 23479 |
PageCount | 7 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_ab29cca05eb74207b6c6a6670aea2957 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8098648 proquest_miscellaneous_2528435397 crossref_primary_10_29219_fnr_v65_5709 pubmed_primary_33994910 |
PublicationCentury | 2000 |
PublicationDate | 2021-05-04 |
PublicationDateYYYYMMDD | 2021-05-04 |
PublicationDate_xml | – month: 05 year: 2021 text: 2021-05-04 day: 04 |
PublicationDecade | 2020 |
PublicationPlace | Sweden |
PublicationPlace_xml | – name: Sweden |
PublicationTitle | Food & nutrition research |
PublicationTitleAlternate | Food Nutr Res |
PublicationYear | 2021 |
Publisher | Open Academia Swedish Nutrition Foundation |
Publisher_xml | – name: Open Academia – name: Swedish Nutrition Foundation |
References | Wyatt (CIT0026) 2011; 68 Li (CIT0032) 2013; 32 Kapron (CIT0023) 1997; 6 Nizard (CIT0031) 2007; 8 da Silva (CIT0016) 2016; 49 Trougakos (CIT0035) 2009; 15 Alsio (CIT0008) 2012; 33 Small (CIT0009) 2003; 19 de Melo Martimiano (CIT0011) 2015; 134 Sahu (CIT0005) 2004; 145 Rohne (CIT0029) 2016; 7 Gregory (CIT0030) 2017; 5 Volkow (CIT0007) 2007; 164 Fortuna (CIT0004) 2012; 44 Urban (CIT0022) 1987; 105 Zhang (CIT0036) 2005; 7 Lizarraga-Mollinedo (CIT0037) 2013; 28 Debure (CIT0033) 2003; 116 da Silva (CIT0015) 2013; 31 Zheng (CIT0006) 2007; 7 Wang (CIT0013) 2001; 357 Vucetic (CIT0014) 2010; 168 Rodriguez-Rivera (CIT0018) 2019; 43 Segula (CIT0001) 2014; 26 Volkow (CIT0012) 2008; 42 Humphreys (CIT0024) 1999; 274 Gil (CIT0020) 2013; 4 Morgan (CIT0039) 1999; 89 Moyse (CIT0038) 2019; 179 Rohne (CIT0027) 2014; 34 Hruby (CIT0002) 2015; 33 Beaulieu (CIT0010) 2011; 63 Clark (CIT0017) 2013; 14 Byun (CIT0021) 2014; 15 Kim (CIT0034) 2012; 99 Carver (CIT0028) 2003; 55 CIT0003 Poon (CIT0025) 2002; 277 Oberbach (CIT0019) 2011; 10 |
References_xml | – ident: CIT0003 publication-title: Obesity and overweight 2020 – volume: 32 start-page: 1933 year: 2013 ident: CIT0032 publication-title: Oncogene doi: 10.1038/onc.2012.212 contributor: fullname: Li – volume: 34 start-page: 1626 year: 2014 ident: CIT0027 publication-title: Cell Physiol Biochem doi: 10.1159/000366365 contributor: fullname: Rohne – volume: 277 start-page: 39532 year: 2002 ident: CIT0025 publication-title: J Biol Chem doi: 10.1074/jbc.M204855200 contributor: fullname: Poon – volume: 26 start-page: 20 year: 2014 ident: CIT0001 publication-title: Malawi Med J contributor: fullname: Segula – volume: 357 start-page: 354 year: 2001 ident: CIT0013 publication-title: Lancet doi: 10.1016/S0140-6736(00)03643-6 contributor: fullname: Wang – volume: 15 start-page: 801 year: 2014 ident: CIT0021 publication-title: EMBO Rep doi: 10.15252/embr.201338317 contributor: fullname: Byun – volume: 19 start-page: 1709 year: 2003 ident: CIT0009 publication-title: Neuroimage doi: 10.1016/S1053-8119(03)00253-2 contributor: fullname: Small – volume: 42 start-page: 1537 year: 2008 ident: CIT0012 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.06.002 contributor: fullname: Volkow – volume: 14 start-page: 216 year: 2013 ident: CIT0017 publication-title: Eat Behav doi: 10.1016/j.eatbeh.2013.01.002 contributor: fullname: Clark – volume: 7 start-page: 607 year: 2007 ident: CIT0006 publication-title: Curr Opin Pharmacol doi: 10.1016/j.coph.2007.10.011 contributor: fullname: Zheng – volume: 5 start-page: 81 year: 2017 ident: CIT0030 publication-title: Acta Neuropathol Commun doi: 10.1186/s40478-017-0481-1 contributor: fullname: Gregory – volume: 63 start-page: 182 year: 2011 ident: CIT0010 publication-title: Pharmacol Rev doi: 10.1124/pr.110.002642 contributor: fullname: Beaulieu – volume: 33 start-page: 673 year: 2015 ident: CIT0002 publication-title: Pharmacoeconomics doi: 10.1007/s40273-014-0243-x contributor: fullname: Hruby – volume: 44 start-page: 56 year: 2012 ident: CIT0004 publication-title: J Psychoactive Drugs doi: 10.1080/02791072.2012.662092 contributor: fullname: Fortuna – volume: 33 start-page: 127 year: 2012 ident: CIT0008 publication-title: Front Neuroendocrinol doi: 10.1016/j.yfrne.2012.01.002 contributor: fullname: Alsio – volume: 7 start-page: 1 year: 2016 ident: CIT0029 publication-title: Biomol Concepts doi: 10.1515/bmc-2015-0026 contributor: fullname: Rohne – volume: 145 start-page: 2613 year: 2004 ident: CIT0005 publication-title: Endocrinology doi: 10.1210/en.2004-0032 contributor: fullname: Sahu – volume: 274 start-page: 6875 year: 1999 ident: CIT0024 publication-title: J Biol Chem doi: 10.1074/jbc.274.11.6875 contributor: fullname: Humphreys – volume: 7 start-page: 909 year: 2005 ident: CIT0036 publication-title: Nat Cell Biol doi: 10.1038/ncb1291 contributor: fullname: Zhang – volume: 6 start-page: 2120 year: 1997 ident: CIT0023 publication-title: Protein Sci doi: 10.1002/pro.5560061007 contributor: fullname: Kapron – volume: 68 start-page: 3919 year: 2011 ident: CIT0026 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-011-0684-8 contributor: fullname: Wyatt – volume: 179 start-page: 51 year: 2019 ident: CIT0038 publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2019.01.002 contributor: fullname: Moyse – volume: 89 start-page: 687 year: 1999 ident: CIT0039 publication-title: Neuroscience doi: 10.1016/S0306-4522(98)00334-0 contributor: fullname: Morgan – volume: 105 start-page: 2735 year: 1987 ident: CIT0022 publication-title: J Cell Biol doi: 10.1083/jcb.105.6.2735 contributor: fullname: Urban – volume: 8 start-page: 554 year: 2007 ident: CIT0031 publication-title: Traffic doi: 10.1111/j.1600-0854.2007.00549.x contributor: fullname: Nizard – volume: 15 start-page: 48 year: 2009 ident: CIT0035 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-08-1805 contributor: fullname: Trougakos – volume: 49 start-page: 50 year: 2016 ident: CIT0016 publication-title: Int J Dev Neurosci doi: 10.1016/j.ijdevneu.2016.01.004 contributor: fullname: da Silva – volume: 43 start-page: 744 year: 2019 ident: CIT0018 publication-title: World J Surg doi: 10.1007/s00268-018-4851-z contributor: fullname: Rodriguez-Rivera – volume: 28 start-page: 111 year: 2013 ident: CIT0037 publication-title: Metab Brain Dis doi: 10.1007/s11011-012-9358-y contributor: fullname: Lizarraga-Mollinedo – volume: 10 start-page: 4769 year: 2011 ident: CIT0019 publication-title: J Proteome Res doi: 10.1021/pr2005555 contributor: fullname: Oberbach – volume: 99 start-page: 240 year: 2012 ident: CIT0034 publication-title: Epilepsy Res doi: 10.1016/j.eplepsyres.2011.12.002 contributor: fullname: Kim – volume: 31 start-page: 334 year: 2013 ident: CIT0015 publication-title: Int J Dev Neurosci doi: 10.1016/j.ijdevneu.2013.05.001 contributor: fullname: da Silva – volume: 168 start-page: 359 year: 2010 ident: CIT0014 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.04.010 contributor: fullname: Vucetic – volume: 55 start-page: 661 year: 2003 ident: CIT0028 publication-title: IUBMB Life doi: 10.1080/15216540310001640498 contributor: fullname: Carver – volume: 4 start-page: 1862 year: 2013 ident: CIT0020 publication-title: Nat Commun doi: 10.1038/ncomms2896 contributor: fullname: Gil – volume: 116 start-page: 3109 year: 2003 ident: CIT0033 publication-title: J Cell Sci doi: 10.1242/jcs.00619 contributor: fullname: Debure – volume: 164 start-page: 708 year: 2007 ident: CIT0007 publication-title: Am J Psychiatry doi: 10.1176/ajp.2007.164.5.708 contributor: fullname: Volkow – volume: 134 start-page: 106 year: 2015 ident: CIT0011 publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2015.04.008 contributor: fullname: de Melo Martimiano |
SSID | ssj0063084 |
Score | 2.2536588 |
Snippet | Food-related disorders are increasingly common in developed societies, and the psychological component of these disorders has been gaining increasing... |
SourceID | doaj pubmedcentral proquest crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 1 |
SubjectTerms | cell survival clusterin food addiction mitochondria Original undernutrition |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LSsQwFA3iShDxbX1RQdx1TPNsljoog6AbFWZWIWlTFIaOzMPv995mRmZEcOOutIWk5yY954abE0IuKZqCC5xpQJaZqCuX-YrXmeFGBacNUD6udzw-qd6reOjL_tJRX1gTFu2BI3DXzjMDrVAZPGRxVHtVKqeUpi44ZmTcR07ZIpmK_2DFaSGioyYzMCev62bc-VSyIzVWHi4xUGvU_5u6_FkkucQ699tkay4X05vYzR2yFppdshnX2tK4hWiP0O5whn4H7006xBqgSQpXuDls3LQegW-hSp972fNADlJcqJ_sk9f7u5duL5ufhJCVXNMp_LJkECxX8NHClwoknldF7cqaMY-H5zBIk2jNgHgCzE9TaIO2NlWlaloVKg_8gKw3oyYckbQ0kMJxp4wrqPC59pL6OtcaAAZi4iEhVwt07Ec0vLCQKLQwWoDRAowWYUzILWL3_RL6VLc3IHp2Hj37V_QScrFA3sK4RgxcE0aziWUSiJNLkEsJOYyR-G6Kg6oSoHMSolditNKX1SfN-1vrnV1Q9KMvjv-j8ydkg2GFC5Y_ilOyPh3PwhlIlKk_b0fjFxAj4xI priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access(OpenAccess) dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS9xAFD6IQhGKaG_GS0mh9C3b2blmHkRUKotgX-yCPg0zyaQKS7bN7or-e89Jdrdu61PfQq6Tb-bkO2dyzjcAnxmJgkuyNCTLTFalz0IpqswKq6M3Fimf5jsuv-vBUF5cq-s_kkJzACcvhna0ntSwGfUefj8eo8EfURqzRYv7WtVN716rnjJUyrfBkRQpu-tSLn8oaMFy2Uls_nvJJrwSyNPSUhntM3ZqRfxf8jz_TqB8xkjn27A1dyXTk67vd2At1m_gdTcPl3blRW-BnY1mpIVwV6cjyg-apLhFhWNN3eoH3sYyvRpkVzfqJqVJ_Mk7GJ5_-3E2yOarJGSFMGyKnzMVJe9r5qMMhUb3L-i88kXFeaCFdTiGUKziSEoRbdfmxpLkTVnqipW57kfxHtbrcR13IS0shnfCa-tzJkPfBMVC1TeGqYikJWICXxbouF-dGIbDIKJF1CGiDhF1hGgCp4Td8iTSsG53jJufbm4SzgducfzgzQO2kpmgC-21NvginltlEvi0QN7hmCcMfB3Hs4njCklVKHSlEvjQ9cTyUYueTMCs9NFKW1aP1He3ra52zkirPt_77yv3YZNTygvlQ8oDWJ82s3iIPss0fGxH4xM9aOqI priority: 102 providerName: Scholars Portal |
Title | Clusterin levels in undernourished SH-SY5Y cells |
URI | https://www.ncbi.nlm.nih.gov/pubmed/33994910 https://search.proquest.com/docview/2528435397 https://pubmed.ncbi.nlm.nih.gov/PMC8098648 https://doaj.org/article/ab29cca05eb74207b6c6a6670aea2957 |
Volume | 65 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFD603ctgjLW71N0WPBh7c6Loaj2uoSUUUsq6QvokJFteA6lSctnv75Ecl2bsqS_G-Cp_OvJ3jjjnE8B3EkXBeRxpSJYFb2pbuJo1hWZaeqs0Un6c75hcyvENv5iK6R6IrhYmJe1XbtYP8_t-mN2l3MqH-2rQ5YkNriajkkRR8XKwD_tIv12I3v5-JSMlb8U0qcbhOGjCsv9Xir5QJEqEMmRkrmPB7DMeSnL9__Mx_02VfMY95-_g7dZpzH-2jTuEPR-O4E0745a3hUTvgYzmm6h6MAv5PGYCrXLciyViy5CUAu98nV-Pi-tbcZvH6frVB7g5P_s9Ghfb9RCKiimyxh-X8JwOJbGeu0qio-dk2diqodTFJXQoBkukoUg_HkepLpWO4jZ1LRtSl3Lo2Uc4CIvgjyGvNAZyzEptS8LdUDlBXDNUigiP9MR8Bj86dMxDK3thMFxIiBpE1CCiJiKawWnE7umiqFadDiyWf8y2z4x1VKOl4MMdtpIoJytppVT4IZZqoTL41iFv0LojBjb4xWZlqED6ZAKdpgw-tT3x9KquJzNQO32005bdM2hQSUF7a0AnL77zM7ymMbklZj7yL3CwXm78V_RO1q6HNjlVPXh1enZ59auXYnzcTnjZS3b6CPMy55g |
link.rule.ids | 230,314,727,780,784,864,885,2102,24318,27924,27925,31720,33745,53791,53793 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB7S9NBCKenbSR8ulN68K0uWZB3TJWHbZkMhCSQnIdlys7DRhn3k93fGXods6ak346f8aaRvRsx8AvjCSBS8oJGGZJkVTe0yX4smM8Ko4LRByqf1jsmpGl8UPy7l5Q7IvhamTdqv_HQQZzeDOL1ucytvb6phnyc2_DUZlYxExcvhI3gshTZ5H6R3E7ASrCw6OU1ucEAOm7gY3Ck5kJqRSKhATi4Mlcw-YKJWsP9fXubfyZIP2Od4D55v3Mb0sGveC9gJ8SU869bc0q6U6BWw0WxNugfTmM4oF2iZ4hEViS1iqxV4Her0bJydXcmrlBbsl6_h4vjofDTONjsiZJXQbIVTlwwFzxVzofCVQlfPq7JxVcO5p010OIZLrOFIQAHHqSm1IXmbulYNq0uVB_EGduM8hneQVgZDOeGUcSUrfK69ZL7JtWYyIEGJkMDXHh172wlfWAwYWkQtImoRUUuIJvCNsLu_ifSq2xPzxW-76TXrPDdoK_hyj61k2qtKOaU0_ojjRuoEPvfIW7RvwsDFMF8vLZdIoEKi25TA264n7j_V92QCequPttqyfQVNqtXQ3pjQ_n8_-QmejM8nJ_bk--nPA3jKKdWF8iCL97C7WqzDB_RVVv5ja5l_AMXW5p0 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Za9wwEB7aFEqhhJ6pe7pQ-ua1Vqf12G67bI-EQBpInoRkS83CRrvs0d-fkb0Ou6VPfTM-5W9G-mbE6BPAB5JEwXnqaUiWBQ-NLVzDQqGZlt4qjZSf5juOT-TknH-_EBc7W321Rfu1mw7i7HoQp1dtbeXiui77OrHy9HhUkSQqXpWLJpR34Z5g6GR9ot4NwpKRineSmlRjpyxDXA7-SDEQiiShUIa8zHVaNrvDRq1o_78izb8LJncYaPwIDrehY_6pa-JjuOPjE3jYzbvl3XKip0BGs03SPpjGfJbqgVY5HqWFYsvY6gVe-SY_mxRnl-IyT5P2q2dwPv76azQptrsiFDVTZI3Dl_CcDiWxnrtaYrjnZBVsHSh1aSMdiikTCRRJyGNf1ZXSSeKmaWQgTSWHnj2HgziP_gXktcZ0jlmpbUW4GyoniAtDpYjwSFLMZ_CxR8csOvELg0lDi6hBRA0iahKiGXxO2N3elDSr2xPz5W-ztZyxjmr0F3y5w1YS5WQtrZQKf8RSLVQG73vkDfp4wsBGP9-sDBVIokxg6JTBUWeJ20_1lsxA7dlory37V9CtWh3trRu9_O8n38H90y9j8_PbyY9X8ICmapdUCslfw8F6ufFvMFxZu7etY94AJAHnsA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clusterin+levels+in+undernourished+SH-SY5Y+cells&rft.jtitle=Food+%26+nutrition+research&rft.au=Rodr%C3%ADguez-Rivera%2C+Carmen&rft.au=P%C3%A9rez-Carri%C3%B3n%2C+Mar%C3%ADa+Dolores&rft.au=Olavarr%C3%ADa%2C+Luc%C3%ADa+Casariego&rft.au=Alguacil%2C+Luis+F.&rft.date=2021-05-04&rft.pub=Open+Academia&rft.eissn=1654-661X&rft.volume=65&rft_id=info:doi/10.29219%2Ffnr.v65.5709&rft_id=info%3Apmid%2F33994910&rft.externalDBID=PMC8098648 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1654-661X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1654-661X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1654-661X&client=summon |