Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway

• Published in: Thrombosis and haemostasis Vol. 120; no. 4; p. 647
• Main Authors: Wan, Lu Ming, Zhang, Shi Kun, Li, Su Bo, Li, Wen, Ji, Shou Ping, Gong, Lin, Yun, Zhi Min, Zhang, Xue, Gao, Hong Wei, Zhong, Hui, Wei, Cong Wen, Bian, Li Hong, Zhuo, Hai Long, Luo, Qun, Li, Jin Ping, Tan, Ying Xia, Gong, Feng
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2020
• Subjects: Carcinogenesis; Cell Differentiation; Extracellular Matrix - metabolism; Feedback, Physiological; Fetal Blood - cytology; Glucuronidase - genetics; Glucuronidase - metabolism; Heparitin Sulfate - metabolism; Humans; Interleukin-6 - metabolism; K562 Cells; Leukemia, Erythroblastic, Acute - metabolism; Leukemia, Erythroblastic, Acute - pathology; Megakaryocytes - cytology; Megakaryocytes - metabolism; Signal Transduction; STAT3 Transcription Factor - metabolism; Tetradecanoylphorbol Acetate - metabolism

Heparanase (HPSE) is an endo-β-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release of cytokines that are immobilized by binding to heparan sulfate proteoglycans (HSPGs), and consequently activating signaling pathways. This...