Synthesis and characterization of fluorescein isothiocyanate (FITC)-labeled PEO–PCL–PEO triblock copolymers for topical delivery

• Published in: Polymer (Guilford) Vol. 50; no. 11; pp. 2357 - 2364
• Main Authors: Cho, Heui Kyoung, Lone, Saifullah, Kim, Dae Duk, Choi, Joon Ho, Choi, Sung Wook, Cho, Jin Hun, Kim, Jung Hyun, Cheong, In Woo
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 22.05.2009; Elsevier
• Subjects: Applied sciences; Biodegradable; Biological and medical sciences; Exact sciences and technology; Fluorescein isothiocyanate; General pharmacology; Medical sciences; Organic polymers; PEO–PCL–PEO; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; Fluorescein isothiocyanate; PEO–PCL–PEO; Biodegradable; Ring opening polymerization; Fluorescence spectrum; Fluorescent tracer; Drug carrier; PEO-PCL-PEO; Caprolactone copolymer; Labelled copolymer; Spherulites; Water oil water emulsion; Molecular aggregation; Amphiphilic polymer; Transdermal system; Control release polymer; Rodentia; Ethylene oxide copolymer; Experimental study; Absorption spectrum; Monodispersed polymer; Vertebrata; Triblock copolymer; Mammalia; Mouse; Animal; Morphology; Preparation; Concentration effect; Aqueous solution; Topical administration

We present the synthesis of fluorescein isothiocyanate (FITC)-labeled poly(ethylene oxide)- block-poly(ɛ-caprolactone)- block-poly(ethylene oxide) (PEO–PCL–PEO) triblock copolymers and their applications for tracking the penetration behavior of FITC-labeled copolymers in the hairless mouse skin. In...