Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality
To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats. Male Wistar rats were divided into: control (C), sedentary-i...
Saved in:
Published in | European heart journal Vol. 32; no. 7; pp. 904 - 912 |
---|---|
Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.04.2011
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats.
Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO(2) max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6%) compared with SI (34 ± 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group.
Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI. |
---|---|
AbstractList | AIMSTo test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats.METHODS AND RESULTSMale Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO(2) max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6%) compared with SI (34 ± 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group.CONCLUSIONEarly aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI. To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats. Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO(2) max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6%) compared with SI (34 ± 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI. |
Author | CURI, Rui IRIGOYEN, Maria-Cláudia CHAKUR BRUM, Patricia MALFITANO, Christiane RODRIGUES, Bruno MEDEIROS, Alessandra MONTANO, Nicola ALBA LOUREIRO, Tatiana Carolina DE ANGELIS, Kátia JORGE, Luciana TEODORO ROSE, Kaleizu LACCHINI, Silvia |
Author_xml | – sequence: 1 givenname: Luciana surname: JORGE fullname: JORGE, Luciana organization: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 44—Subsolo, São Paulo, SP 05403-000, Brazil – sequence: 2 givenname: Bruno surname: RODRIGUES fullname: RODRIGUES, Bruno organization: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 44—Subsolo, São Paulo, SP 05403-000, Brazil – sequence: 3 givenname: Kátia surname: DE ANGELIS fullname: DE ANGELIS, Kátia organization: Human Movement Laboratory, São Judas Tadeu University, São Paulo, Brazil – sequence: 4 givenname: Maria-Cláudia surname: IRIGOYEN fullname: IRIGOYEN, Maria-Cláudia organization: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 44—Subsolo, São Paulo, SP 05403-000, Brazil – sequence: 5 givenname: Kaleizu surname: TEODORO ROSE fullname: TEODORO ROSE, Kaleizu organization: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 44—Subsolo, São Paulo, SP 05403-000, Brazil – sequence: 6 givenname: Christiane surname: MALFITANO fullname: MALFITANO, Christiane organization: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 44—Subsolo, São Paulo, SP 05403-000, Brazil – sequence: 7 givenname: Tatiana Carolina surname: ALBA LOUREIRO fullname: ALBA LOUREIRO, Tatiana Carolina organization: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil – sequence: 8 givenname: Alessandra surname: MEDEIROS fullname: MEDEIROS, Alessandra organization: School of Physical Education and Sports of University of São Paulo, São Paulo, Brazil – sequence: 9 givenname: Rui surname: CURI fullname: CURI, Rui organization: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil – sequence: 10 givenname: Patricia surname: CHAKUR BRUM fullname: CHAKUR BRUM, Patricia organization: School of Physical Education and Sports of University of São Paulo, São Paulo, Brazil – sequence: 11 givenname: Silvia surname: LACCHINI fullname: LACCHINI, Silvia organization: Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil – sequence: 12 givenname: Nicola surname: MONTANO fullname: MONTANO, Nicola organization: Department of Clinical Sciences, Internal Medicine II, Luigi Sacco Hospital, University of Milan, Milan, Italy |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24024047$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20675661$$D View this record in MEDLINE/PubMed |
BookMark | eNpFkU9r3DAQxUVJaTZp7z0VXUpPbiRblu3eytJ_EMilgdzMWB53tdiSM5KT7lfrp6vc3SYwSIz4vadh3gU7c94hY2-l-ChFU1zhQjsEivsr3N3nSr1gG1nmedZoVZ6xjZBNmWld352zixD2QohaS_2KnedCV6XWcsP-bIF6C4aD6_mMZOcdEowc-v0S4oQuBm5dvxjseXfg6bMxnb-RjA3II4F11v1KSER6SLT1jj8iIYcQvLEQk-7Rxh2HJXrnJ2u4nWbyD7h6J12qAcisHEEMnzj5Edf3YXFmtUvDGJjB2Hj4N-TkKcKYutfs5QBjwDen-5Ldfv3yc_s9u7759mP7-TozRSViVmlp5NANVVN3Q16KvktNrppGCJ1WIOtC1NUga1WovpLQFCUYDQIbqHUDShWX7MPRN419v2CI7WSDwXEEh34Jba1FMtGVSKQ4koZ8CIRDO5OdgA6tFO0aWPsUWHsMLEnencyXbsL-SfA_oQS8PwEQDIwDgUurf-aUSKWq4i8FB6lh |
CitedBy_id | crossref_primary_10_1152_ajpheart_00253_2017 crossref_primary_10_3389_fphys_2018_00053 crossref_primary_10_1371_journal_pone_0087935 crossref_primary_10_1186_s12933_014_0131_x crossref_primary_10_1186_s12872_015_0099_9 crossref_primary_10_1155_2014_702473 crossref_primary_10_2174_1573403X15666190729153026 crossref_primary_10_1093_eurheartj_ehr299 crossref_primary_10_1371_journal_pone_0048826 crossref_primary_10_1186_1471_2261_14_84 crossref_primary_10_1113_EP086076 crossref_primary_10_1186_s12902_021_00795_6 crossref_primary_10_1111_1440_1681_12121 crossref_primary_10_1152_ajpregu_00098_2018 crossref_primary_10_1152_ajpregu_00445_2013 crossref_primary_10_1186_s13019_024_02756_1 crossref_primary_10_1007_s00421_012_2533_3 crossref_primary_10_1016_j_lfs_2022_121181 crossref_primary_10_1590_1517_869220182404175002 crossref_primary_10_1016_j_repc_2019_02_013 crossref_primary_10_34172_mj_2020_015 crossref_primary_10_1007_s00424_023_02788_x crossref_primary_10_1016_j_cardfail_2012_07_006 crossref_primary_10_1152_japplphysiol_00883_2014 crossref_primary_10_1016_j_ijcard_2016_10_061 crossref_primary_10_1186_1550_2783_9_13 crossref_primary_10_1007_s11684_012_0171_0 crossref_primary_10_52547_koomesh_23_2_267 crossref_primary_10_1016_j_ijcard_2016_07_072 crossref_primary_10_1038_s41598_017_14021_8 crossref_primary_10_1155_2024_6632656 crossref_primary_10_1016_j_jdiacomp_2012_08_002 crossref_primary_10_1590_S1807_59322011000800022 crossref_primary_10_1113_expphysiol_2011_059360 crossref_primary_10_1038_aps_2013_147 crossref_primary_10_1590_S0100_879X2011007500075 crossref_primary_10_1016_j_repce_2019_02_014 |
Cites_doi | 10.1111/j.1440-1681.2008.05070.x 10.1016/j.yjmcc.2007.10.004 10.1161/01.HYP.0000176238.90688.6b 10.1001/jama.2009.457 10.1161/01.CIR.102.21.2588 10.1161/HYPERTENSIONAHA.107.095000 10.1084/jem.189.11.1699 10.1096/fj.01-0256com 10.1161/01.CIR.85.6.2119 10.1016/j.autneu.2008.10.010 10.1590/S0100-879X2006000500016 10.1152/ajpheart.01352.2005 10.1016/0003-2697(76)90527-3 10.1016/j.autneu.2006.10.004 10.1161/01.CIR.99.7.963 10.1136/heart.85.3.331 10.1093/eurjhf/hfp020 10.1590/S0100-879X2005000100018 10.1113/jphysiol.2006.113357 10.1161/01.RES.68.5.1294 10.1152/ajpheart.01393.2007 10.1093/eurheartj/ehi067 10.1007/s11373-008-9237-z 10.1016/S0008-6363(97)00275-7 10.1111/j.1440-1681.2007.04820.x 10.2165/00019053-200826060-00001 10.1093/nar/29.9.e45 10.1161/01.CIR.96.6.1790 10.1023/A:1009889922985 10.1161/hy0102.099200 10.1016/j.jacc.2004.11.052 10.1093/oxfordjournals.eurheartj.a060941 10.1152/japplphysiol.00493.2007 10.1161/01.CIR.79.2.324 10.1016/0003-2697(87)90021-2 10.1152/japplphysiol.00487.2003 10.1007/s10741-007-9057-7 10.1016/S0140-6736(97)11144-8 10.1016/0002-9149(92)90998-E 10.1186/1475-2840-6-38 10.1006/meth.2001.1262 10.1161/01.CIR.57.5.958 |
ContentType | Journal Article |
Copyright | 2015 INIST-CNRS |
Copyright_xml | – notice: 2015 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1093/eurheartj/ehq244 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1522-9645 |
EndPage | 912 |
ExternalDocumentID | 10_1093_eurheartj_ehq244 20675661 24024047 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K -E4 .2P .GJ .I3 .XZ .ZR 08P 0R~ 18M 1B1 1TH 29G 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 6.Y 70D AABJS AABMN AABZA AACZT AAESY AAIYJ AAJKP AAJQQ AAMVS AANRK AAOGV AAPBV AAPGJ AAPNW AAPQZ AAPXW AAUQX AAVAP AAWDT ABEUO ABIXL ABKDP ABNKS ABOCM ABPTD ABQLI ABQTQ ABSAR ABSMQ ABWST ABZBJ ACFRR ACGFO ACGFS ACIMA ACPQN ACPRK ACUFI ACUTJ ACUTO ACYHN ADBBV ADEIU ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADORX ADQLU ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKPW AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFZL AFIYH AFOFC AFXAL AFXEN AFYAG AGINJ AGKEF AGKRT AGQXC AGSYK AGUTN AHMBA AHXPO AI. AIAGR AIJHB AIKOY AIMBJ AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APJGH APWMN AQDSO AQKUS ASMCH ASPBG ATTQO AVWKF AWCFO AXUDD AZFZN AZQFJ BAWUL BAYMD BCGUY BCRHZ BEYMZ BGYMP BHONS BTRTY BVRKM BYORX BZKNY C1A C45 CAG CASEJ CDBKE COF CS3 CZ4 DAKXR DIK DILTD DPORF DPPUQ D~K E3Z EBS EE~ EIHJH EJD EMOBN ENERS F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HZ~ IHE IOX IQODW J21 KAQDR KBUDW KC5 KOP KQ8 KSI KSN L7B M-Z M41 M49 MBLQV MHKGH ML0 N4W N9A NGC NOMLY NOYVH NQ- NTWIH NU- NVLIB O0~ O9- OAUYM OAWHX OB3 OBFPC OCZFY ODMLO OGROG OJQWA OK1 OPAEJ OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RIG RNI ROL ROX ROZ RPZ RUSNO RW1 RXO RZF SEL TCURE TEORI TJX TMA UHS VH1 W8F WOQ X7H YAYTL YKOAZ YXANX ZA5 ZGI ZKX ~91 AARHZ AASNB AAUAY ABNHQ ABQNK ABXVV ACMRT ACZBC ADQBN AEHUL AFSHK AGMDO ATGXG AVNTJ CGR CUY CVF ECM EIF HVGLF NPM OJZSN AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c370t-761c1fbf798bf250dbfbf2499006661183087f18434d71a935ac6a0e9a869a443 |
ISSN | 0195-668X |
IngestDate | Fri Aug 16 10:11:02 EDT 2024 Thu Sep 12 17:02:56 EDT 2024 Sat Sep 28 08:35:47 EDT 2024 Sun Oct 22 16:06:45 EDT 2023 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7 |
Keywords | Heart Physical exercise Myocardial infarction Cardiac performance Prognosis Rat Cardiovascular disease Myocardial disease Functional capacity Improvement Autonomic function Exercise tolerance test Exercise training Cardiology Adjustment Mortality Rodentia Coronary heart disease Blood flow Vertebrata Mammalia Animal Cardiac function Early Circulatory system Hemodynamics |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c370t-761c1fbf798bf250dbfbf2499006661183087f18434d71a935ac6a0e9a869a443 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://academic.oup.com/eurheartj/article-pdf/32/7/904/7110009/ehq244.pdf |
PMID | 20675661 |
PQID | 860183670 |
PQPubID | 23479 |
PageCount | 9 |
ParticipantIDs | proquest_miscellaneous_860183670 crossref_primary_10_1093_eurheartj_ehq244 pubmed_primary_20675661 pascalfrancis_primary_24024047 |
PublicationCentury | 2000 |
PublicationDate | 2011-04-01 |
PublicationDateYYYYMMDD | 2011-04-01 |
PublicationDate_xml | – month: 04 year: 2011 text: 2011-04-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | Oxford |
PublicationPlace_xml | – name: Oxford – name: England |
PublicationTitle | European heart journal |
PublicationTitleAlternate | Eur Heart J |
PublicationYear | 2011 |
Publisher | Oxford University Press |
Publisher_xml | – name: Oxford University Press |
References | (24_29803760) 2008; 104 (14_19441630) 2005; 46 Shephard (27_10732767) 1999; 99 La Rovere (2_5900078) 1998; 351 Yamashita (32_11047410) 2001; 85 Wang (42_9437453) 1991; 68 Sullivan (25_5131290) 1989; 79 (34_37736781) 2009; 296 Malliani (41_11481946) 2002; 39 (33_19597651) 2003; 95 (38_30707267) 1998; 37 (4_37736780) 2006; 291 Esler (7_19470881) 2000; 5 Coats (39_9843776) 1992; 85 (13_29157015) 2007; 50 De Angelis (17_18633881) 2005; 38 Xu (36_30201428) 2008; 44 (3_36676212) 2008; 26 (21_34039947) 2009; 11 Flynn (8_34487119) 2009; 301 (31_35862303) 1999; 189 Rodrigues (12_30094130) 2007; 6 Negrao (1_30092630) 2008; 13 (6_25154756) 1993; 87 de Macedo Braga (10_30928098) 2008; 15 KNOX (23_11385362) 2001; 15 Chomczynski (18_14196913) 1987; 162 Mostarda (16_32698350) 2009; 145 McElroy (30_4537971) 1978; 57 Livak (20_16917659) 2001; 25 (35_22622532) 2006; 577 Freimann (26_18735852) 2005; 45 Pfaffl (19_17287503) 2001; 29 Iellamo (43_10558661) 2000; 102 (11_34943947) 2007; 26 Bradford (22_4058442) 1976; 72 Andrews Portes (29_32561936) 2009; 36 Nozawa (28_22062862) 2006; 39 KIlLAVUORI (40_16006024) 1995; 16 Giannuzzi (37_5753736) 1997; 96 (44_18698970) 2005; 26 Ferguson (5_9718103) 1992; 69 Harthmann (15_28458723) 2007; 133 Braga (9_30292023) 2008; 35 |
References_xml | – volume: 36 start-page: 394 issn: 0305-1870 issue: 4 year: 2009 ident: 29_32561936 publication-title: Clinical and experimental pharmacology & physiology doi: 10.1111/j.1440-1681.2008.05070.x contributor: fullname: Andrews Portes – volume: 44 start-page: 114 issn: 0022-2828 issue: 1 year: 2008 ident: 36_30201428 publication-title: Journal of molecular and cellular cardiology doi: 10.1016/j.yjmcc.2007.10.004 contributor: fullname: Xu – volume: 46 start-page: 998 issn: 0194-911X issue: 4 year: 2005 ident: 14_19441630 publication-title: Hypertension doi: 10.1161/01.HYP.0000176238.90688.6b – volume: 301 start-page: 1451 issn: 0098-7484 issue: 14 year: 2009 ident: 8_34487119 publication-title: JAMA doi: 10.1001/jama.2009.457 contributor: fullname: Flynn – volume: 102 start-page: 2588 issn: 0009-7322 issue: 21 year: 2000 ident: 43_10558661 publication-title: Circulation doi: 10.1161/01.CIR.102.21.2588 contributor: fullname: Iellamo – volume: 50 start-page: 786 issn: 0194-911X issue: 4 year: 2007 ident: 13_29157015 publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.107.095000 – volume: 189 start-page: 1699 issn: 0022-1007 issue: 11 year: 1999 ident: 31_35862303 publication-title: Journal of Experimental Medicine doi: 10.1084/jem.189.11.1699 – volume: 15 start-page: 2480 issn: 0892-6638 issue: 13 year: 2001 ident: 23_11385362 publication-title: The FASEB Journal doi: 10.1096/fj.01-0256com contributor: fullname: KNOX – volume: 85 start-page: 2119 issn: 0009-7322 issue: 6 year: 1992 ident: 39_9843776 publication-title: Circulation doi: 10.1161/01.CIR.85.6.2119 contributor: fullname: Coats – volume: 145 start-page: 11 issn: 1566-0702 issue: 1-2 year: 2009 ident: 16_32698350 publication-title: Autonomic neuroscience : basic & clinical doi: 10.1016/j.autneu.2008.10.010 contributor: fullname: Mostarda – volume: 39 start-page: 687 issn: 0100-879X issue: 5 year: 2006 ident: 28_22062862 publication-title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas m dicas e biol gicas / Sociedade Brasileira de Biof sica ... [et al.] doi: 10.1590/S0100-879X2006000500016 contributor: fullname: Nozawa – volume: 291 start-page: 2801 issn: 0363-6135 year: 2006 ident: 4_37736780 publication-title: American Journal of Physiology - Heart and Circulatory Physiology doi: 10.1152/ajpheart.01352.2005 – volume: 72 start-page: 248 issn: 0003-2697 year: 1976 ident: 22_4058442 publication-title: Analytical biochemistry doi: 10.1016/0003-2697(76)90527-3 contributor: fullname: Bradford – volume: 133 start-page: 115 issn: 1566-0702 issue: 2 year: 2007 ident: 15_28458723 publication-title: Autonomic neuroscience : basic & clinical doi: 10.1016/j.autneu.2006.10.004 contributor: fullname: Harthmann – volume: 87 start-page: 5 issn: 0009-7322 year: 1993 ident: 6_25154756 publication-title: Circulation – volume: 99 start-page: 963 issn: 0009-7322 issue: 7 year: 1999 ident: 27_10732767 publication-title: Circulation doi: 10.1161/01.CIR.99.7.963 contributor: fullname: Shephard – volume: 85 start-page: 331 issn: 0007-0769 issue: 3 year: 2001 ident: 32_11047410 publication-title: Heart doi: 10.1136/heart.85.3.331 contributor: fullname: Yamashita – volume: 11 start-page: 342 issn: 1388-9842 issue: 4 year: 2009 ident: 21_34039947 publication-title: European Journal of Heart Failure doi: 10.1093/eurjhf/hfp020 – volume: 38 start-page: 119 issn: 0100-879X issue: 1 year: 2005 ident: 17_18633881 publication-title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas m dicas e biol gicas / Sociedade Brasileira de Biof sica ... [et al.] doi: 10.1590/S0100-879X2005000100018 contributor: fullname: De Angelis – volume: 577 start-page: 671 issn: 0022-3751 issue: 2 year: 2006 ident: 35_22622532 publication-title: The Journal of Physiology doi: 10.1113/jphysiol.2006.113357 – volume: 68 start-page: 1294 issn: 0009-7330 issue: 5 year: 1991 ident: 42_9437453 publication-title: Circulation Research doi: 10.1161/01.RES.68.5.1294 contributor: fullname: Wang – volume: 296 start-page: 389 issn: 0363-6135 year: 2009 ident: 34_37736781 publication-title: American Journal of Physiology - Heart and Circulatory Physiology doi: 10.1152/ajpheart.01393.2007 – volume: 26 start-page: 357 issn: 0195-668X issue: 4 year: 2005 ident: 44_18698970 publication-title: European Heart Journal doi: 10.1093/eurheartj/ehi067 – volume: 15 start-page: 365 issn: 1021-7770 issue: 3 year: 2008 ident: 10_30928098 publication-title: Journal of biomedical science doi: 10.1007/s11373-008-9237-z contributor: fullname: de Macedo Braga – volume: 37 start-page: 367 issn: 0008-6363 issue: 2 year: 1998 ident: 38_30707267 publication-title: Cardiovascular Research doi: 10.1016/S0008-6363(97)00275-7 – volume: 26 start-page: 6 issn: 1475-2840 year: 2007 ident: 11_34943947 – volume: 35 start-page: 113 issn: 0305-1870 issue: 2 year: 2008 ident: 9_30292023 publication-title: Clinical and experimental pharmacology & physiology doi: 10.1111/j.1440-1681.2007.04820.x contributor: fullname: Braga – volume: 26 start-page: 447 issn: 1179-2027 year: 2008 ident: 3_36676212 doi: 10.2165/00019053-200826060-00001 – volume: 29 start-page: e45 issn: 0305-1048 issue: 9 year: 2001 ident: 19_17287503 publication-title: Nucleic Acids Research doi: 10.1093/nar/29.9.e45 contributor: fullname: Pfaffl – volume: 96 start-page: 1790 issn: 0009-7322 issue: 6 year: 1997 ident: 37_5753736 publication-title: Circulation doi: 10.1161/01.CIR.96.6.1790 contributor: fullname: Giannuzzi – volume: 5 start-page: 17 issn: 1382-4147 issue: 1 year: 2000 ident: 7_19470881 publication-title: Heart failure reviews doi: 10.1023/A:1009889922985 contributor: fullname: Esler – volume: 39 start-page: 63 issn: 0194-911X issue: 1 year: 2002 ident: 41_11481946 publication-title: Hypertension doi: 10.1161/hy0102.099200 contributor: fullname: Malliani – volume: 45 start-page: 931 issn: 0735-1097 issue: 6 year: 2005 ident: 26_18735852 publication-title: Journal of the American College of Cardiology doi: 10.1016/j.jacc.2004.11.052 contributor: fullname: Freimann – volume: 16 start-page: 490 issn: 0195-668X issue: 4 year: 1995 ident: 40_16006024 publication-title: European Heart Journal doi: 10.1093/oxfordjournals.eurheartj.a060941 contributor: fullname: KIlLAVUORI – volume: 104 start-page: 103 issn: 0021-8987 issue: 1 year: 2008 ident: 24_29803760 publication-title: Journal of Applied Physiology doi: 10.1152/japplphysiol.00493.2007 – volume: 79 start-page: 324 issn: 0009-7322 issue: 2 year: 1989 ident: 25_5131290 publication-title: Circulation doi: 10.1161/01.CIR.79.2.324 contributor: fullname: Sullivan – volume: 162 start-page: 156 issn: 0003-2697 issue: 1 year: 1987 ident: 18_14196913 publication-title: Analytical biochemistry doi: 10.1016/0003-2697(87)90021-2 contributor: fullname: Chomczynski – volume: 95 start-page: 2510 issn: 0021-8987 issue: 6 year: 2003 ident: 33_19597651 publication-title: Journal of Applied Physiology doi: 10.1152/japplphysiol.00487.2003 – volume: 13 start-page: 51 issn: 1382-4147 issue: 1 year: 2008 ident: 1_30092630 publication-title: Heart failure reviews doi: 10.1007/s10741-007-9057-7 contributor: fullname: Negrao – volume: 351 start-page: 478 issn: 0140-6736 issue: 9101 year: 1998 ident: 2_5900078 publication-title: Lancet doi: 10.1016/S0140-6736(97)11144-8 contributor: fullname: La Rovere – volume: 69 start-page: 523 issn: 0002-9149 issue: 5 year: 1992 ident: 5_9718103 publication-title: The American journal of cardiology doi: 10.1016/0002-9149(92)90998-E contributor: fullname: Ferguson – volume: 6 start-page: 38 issn: 1475-2840 year: 2007 ident: 12_30094130 doi: 10.1186/1475-2840-6-38 contributor: fullname: Rodrigues – volume: 25 start-page: 402 issn: 1046-2023 issue: 4 year: 2001 ident: 20_16917659 publication-title: Methods (San Diego, Calif.) doi: 10.1006/meth.2001.1262 contributor: fullname: Livak – volume: 57 start-page: 958 issn: 0009-7322 issue: 5 year: 1978 ident: 30_4537971 publication-title: Circulation doi: 10.1161/01.CIR.57.5.958 contributor: fullname: McElroy |
SSID | ssj0008616 |
Score | 2.2593718 |
Snippet | To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen... AIMSTo test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal... |
SourceID | proquest crossref pubmed pascalfrancis |
SourceType | Aggregation Database Index Database |
StartPage | 904 |
SubjectTerms | Animals Autonomic Nervous System Diseases - physiopathology Baroreflex - physiology Biological and medical sciences Body Weight Cardiac Output - physiology Cardiology. Vascular system Coronary heart disease Echocardiography Heart Heart Rate - physiology Kaplan-Meier Estimate Male Medical sciences Microspheres Myocardial Infarction - mortality Myocardial Infarction - physiopathology Myocarditis. Cardiomyopathies Oxygen Consumption - physiology Physical Conditioning, Animal Rats Rats, Wistar Regional Blood Flow - physiology Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Vascular Endothelial Growth Factor A - metabolism Ventricular Dysfunction, Left - physiopathology |
Title | Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality |
URI | https://www.ncbi.nlm.nih.gov/pubmed/20675661 https://search.proquest.com/docview/860183670 |
Volume | 32 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELbKIiEkhHhTHqs5cEFVumnr2Ak3WAErxHLqSr1FjuNAV0u7tIkQ_DT-Dn-EGdtxUmAllkuUOo1la7543jOMPUsoLwQ5V8QTJSNuuIlSFcuonKa6lGVJ-aIUbfFBHJ3wd4tkMRj87EUtNXUx1t__mlfyP1TFMaQrZclegrJhUhzAe6QvXpHCeP0nGh9a8rqCq1Sx2JYIOBup8rTZ1i53DVXuRjsp09haxm2PpdAcwlaMCGGPXw05FDzN2tB01dQufZmSKjdrW2LcthbATeCHQv9DINngOhutiE-IX3ozo0Z-rEnYp2V-tuL-st7xJgeXALXXrkf9vdvgno3r__5-3LmHys3yY-OOuFe94a3LcBuP5mHwWJ1VSxSBnU143DdzkN02RMd4y2eWRELYPsTIuPxpjZp0Jlw9yvY478ylTRuE7M7mzPU59mw-c9Hbf3AQV13LNBu741O6__RlynnHL9sYgd_YaAhudG79WR7myN0MV9jVqcwSshC8XXRxSKmw_XnD_rwvHWc4CDMcuBl2ZKcb52qLn3Hl-q9crCBZQWl-i930Gg68dHC9zQZmdYddO_YxHHfZD49aQDhAh1rooRY8aqH4Bha10KIWWtRCH7VAqIUOtUCohYBa6KEW34OAWiDUvgDCLI13mIUWs3aRAbP32Mmb1_PDo8h3EIn0TMZ1JMVET6qikllaVCjslwX-mKKST5K2QN2a6mFW1PKIl3KislmitFCxyVQqMsX57D7bW61X5iGDiSgLPeElavyKm0IWVVqkZDatpNZVNRuy5y1t8nNXKCa_CAlDtr9DvPACuTp5zOWQQUvNHI978uGplVk32zwVMa5ayHjIHjgqdy-T8o-7enSJlTxm17uP7QnbqzeNeYpSdl3sW5T-Aups434 |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cardiac+and+peripheral+adjustments+induced+by+early+exercise+training+intervention+were+associated+with+autonomic+improvement+in+infarcted+rats%3A+role+in+functional+capacity+and+mortality&rft.jtitle=European+heart+journal&rft.au=Jorge%2C+L.&rft.au=Rodrigues%2C+B.&rft.au=Rosa%2C+K.+T.&rft.au=Malfitano%2C+C.&rft.date=2011-04-01&rft.issn=0195-668X&rft.eissn=1522-9645&rft.volume=32&rft.issue=7&rft.spage=904&rft.epage=912&rft_id=info:doi/10.1093%2Feurheartj%2Fehq244&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_eurheartj_ehq244 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0195-668X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0195-668X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0195-668X&client=summon |