Punicic acid ameliorates obesity and liver steatosis by regulating gut microbiota composition in mice

• Published in: Food & function Vol. 12; no. 17; pp. 7897 - 798
• Main Authors: Yuan, Gaofeng, Tan, Meijuan, Chen, Xiaoe
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 07.09.2021
• Subjects: Animals; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bacteria - metabolism; Bacteroidaceae; Body weight; body weight changes; Body weight gain; Cholesterol; Composition; Desulfovibrionaceae; Diet; Diet, High-Fat - adverse effects; Dietary supplements; epididymis; Fatty liver; Fatty Liver - diet therapy; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - microbiology; Gastrointestinal Microbiome; Helicobacteraceae; High fat diet; Humans; Intestinal microflora; intestinal microorganisms; Lactobacillus; Linolenic Acids - metabolism; Liver; Liver - drug effects; Liver - metabolism; Male; Mice; Mice, Inbred ICR; Microbiota; Mucispirillum; Obesity; Obesity - diet therapy; Obesity - etiology; Obesity - metabolism; Obesity - microbiology; Plant Oils - chemistry; Plant Oils - metabolism; Pomegranate - chemistry; Pomegranate - metabolism; punicic acid; Roseburia; Seeds - chemistry; Seeds - metabolism; Steatosis; triacylglycerols; Triglycerides

This study aimed to elucidate the effect of punicic acid (PUA, cis 9, trans 11, cis 13-18 : 3) on obesity and liver steatosis in mice induced by high-fat diet (HFD), and to explore the possible mechanism. Mice were fed with either a HFD or a control diet for 8 weeks. Half of HFD-mice received daily...