Hematologic toxicities of sunitinib in patients with gastrointestinal stromal tumors: a systematic review and meta-analysis

• Published in: International journal of colorectal disease Vol. 37; no. 7; pp. 1525 - 1534
• Main Authors: Jiang, Xuehui, Xiong, Fangfang, Fu, Qun, Peng, Hongwei, Jing, Yan, Rexiti, Kaisaner, Wei, Xiaohua, Tao, Song
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2022; Springer; Springer Nature B.V
• Subjects: Analysis; Anemia; Care and treatment; Complications and side effects; Gastroenterology; Gastrointestinal cancer; Hepatology; Imatinib; Internal Medicine; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Meta-analysis; Neutropenia; Proctology; Review; Surgery; Targeted cancer therapy; Thrombocytopenia; Tumors; Hematologic toxicities; Sunitinib; GIST; Meta-analysis

Purpose Sunitinib offers a significant survival benefit to patients with imatinib-resistant gastrointestinal stromal tumors (GIST). However, the incidence and risk of sunitinib-induced hematologic toxicities in such a population are often overlooked and have not been well characterized. This meta-an...