Valdecoxib Recovers the Lipid Composition, Order and Dynamics in Colon Cancer Cell Lines Independent of COX-2 Expression: An ATR-FTIR Spectroscopy Study

• Published in: Applied spectroscopy Vol. 71; no. 1; p. 105
• Main Authors: Inan Genç, Aysun, Gok, Seher, Banerjee, Sreeparna, Severcan, Feride
• Format: Journal Article
• Language: English
• Published: United States 01.01.2017
• Subjects: Alkenes - analysis; Alkenes - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - toxicity; Cell Line, Tumor; Cell Survival - drug effects; Cluster Analysis; Colonic Neoplasms - metabolism; Cyclooxygenase 2 Inhibitors - pharmacology; Cyclooxygenase 2 Inhibitors - toxicity; HT29 Cells; Humans; Isoxazoles - pharmacology; Isoxazoles - toxicity; Spectroscopy, Fourier Transform Infrared - methods; Sulfonamides - pharmacology; Sulfonamides - toxicity; ATR-FT-IR spectroscopy; attenuated total reflection infrared spectroscopy; COX-2 inhibitors; HT29; Colon cancer; valdecoxib; SW620

Prostanoids play an important role in a variety of physiological and pathophysiological processes including inflammation and cancer. The rate-limiting step in the prostanoid biosynthesis pathway is catalyzed by cyclooxygenases (COXs). Aberrant expression of the inducible isoform COX-2 plays a signif...