APO(a) Variants and Lipoprotein(a) in Men with or without Myocardial Infarction

• Published in: Experimental and molecular pathology Vol. 73; no. 1; pp. 28 - 34
• Main Authors: Chimienti, Guglielmina, Lamanuzzi, Biagia L., Nardulli, Marina, Colacicco, Anna M., Capurso, Antonio, La Gioia, Rocco, Scrutinio, Domenico, Pepe, Gabriella
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.08.2002; Elsevier
• Subjects: 5' Flanking Region; Alleles; apo(a) gene variants; Apolipoproteins A - genetics; Base Sequence; Biological and medical sciences; Cardiology. Vascular system; cardiovascular diseases; Coronary heart disease; Gene Frequency; genetic determinism; Genetic Testing; Genotype; Heart; Humans; Italy - epidemiology; Kringles - genetics; Lipoprotein(a) - blood; Lipoprotein(a) - genetics; Lp(a); Male; Medical sciences; Middle Aged; Molecular Sequence Data; multifactorial disease; myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - epidemiology; Myocardial Infarction - genetics; Polymorphism, Genetic; Prevalence; Protein Structure, Tertiary - genetics; Regression Analysis; Repetitive Sequences, Nucleic Acid - genetics; Risk Factors; Italy; genetic determinism; apo(a) gene variants; cardiovascular diseases; Lp(a); myocardial infarction; multifactorial disease; Human; Infarct; Cardiovascular disease; Lipoprotein; Coronary heart disease; Myocardial disease; Genetic determinism; Variant; Apolipoprotein A; Risk factor; Cytogenetics; Myocardium; Adult; Molecular biology; Comparative study

The lipoprotein Lp(a) with high plasma concentration is an independent genetic determinant for cardiovascular diseases. It was investigated as a quantitative factor of risk for myocardial infarction. A total of 345 Italian subjects, 127 Cases and 218 Controls, were studied. Lipids and lipoproteins w...