Possible myocardial toxicity associated with interleukin-4 therapy
Interleukin (IL)-4 is a cytokine produced by T lymphocytes, which may play a role in allergic inflammatory processes through its stimulatory effects on immunoglobulin E production and mast cells. In this report, we describe a patient with metastatic melanoma involving the heart who had biopsy-proven...
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Published in | Journal of immunotherapy with emphasis on tumor immunology Vol. 14; no. 4; p. 348 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.11.1993
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Subjects | |
Online Access | Get more information |
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Summary: | Interleukin (IL)-4 is a cytokine produced by T lymphocytes, which may play a role in allergic inflammatory processes through its stimulatory effects on immunoglobulin E production and mast cells. In this report, we describe a patient with metastatic melanoma involving the heart who had biopsy-proven myocarditis after treatment with high-dose IL-4. Because of the uncharacteristic predominance of polymorphonuclear and mast cells in the inflammatory infiltrate of this patient's myocardium, we postulate a unique mechanism of IL-4-associated myocarditis. Three other patients treated with IL-4 had less well-defined cardiac abnormalities, suggesting that patients receiving IL-4 may be at risk for cardiac toxicity. Additional studies will be necessary to confirm such an association. |
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ISSN: | 1067-5582 |
DOI: | 10.1097/00002371-199311000-00015 |