Spray-Drying of Hydroxypropyl β-Cyclodextrin Microcapsules for Co-Encapsulation of Resveratrol and Piperine with Enhanced Solubility

• Published in: Crystals (Basel) Vol. 12; no. 5; p. 596
• Main Authors: Yang, Xing, Shen, Jian, Liu, Jia, Yang, Yuxin, Hu, Anna, Ren, Na, Cheng, Zeneng, Liu, Wenjie
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.05.2022
• Subjects: Aluminum; antioxidant; Antioxidants; Bioavailability; Cyclodextrins; Drying; Efficiency; Encapsulation; hydroxypropyl β-cyclodextrin; Inclusion complexes; Ingredients; Microencapsulation; Particle size; piperine; resveratrol; Scanning electron microscopy; Scavenging; Solubility; Spectrum analysis; spray-drying; Strong interactions (field theory); China; Japan; Germany
• DOI: 10.3390/cryst12050596
• ISSN: 2073-4352

The synergistic therapeutic benefits of resveratrol (RES) and piperine (PIP) have been proven for the treatment of various diseases. This study reports, for the first time, spray-drying of hydroxypropyl β-cyclodextrin (HP-β-CD) microcapsules for combined delivery of resveratrol and piperine. Phase solubility studies indicated that there was a strong interaction between the active ingredients and HP-β-CD, and both active ingredients can bind stably to HP-β-CD. The results of FTIR, XRD, and DSC demonstrated that RES-PIP/HP-β-CD inclusion complexes were successfully formed, with the RES and PIP encapsulated into the hollow spherical cavity of HP-β-CD. The results of SEM showed that the spray-dried microcapsules displayed a smooth surface and uniform particle size. Upon the formation of the spray-dried microcapsules, both RES and PIP presented significantly enhanced solubility. The results of DPPH and ABTS+ scavenging activity assays showed that the spray-drying process did not adversely influence the antioxidant activity of the bioactives, and the addition of PIP increased the antioxidation performance of RES.