Nickel-catalyzed formation of quaternary carbon centers using tertiary alkyl electrophiles

• Published in: Chemical Society reviews Vol. 5; no. 6; pp. 4162 - 4184
• Main Authors: Xue, Weichao, Jia, Xiao, Wang, Xuan, Tao, Xianghua, Yin, Zhigang, Gong, Hegui
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.03.2021
• Subjects: Adducts; alcohols; Carbon; Carboxylic acids; Cascade chemical reactions; Chemical reactions; Covalent bonds; Interception; Lewis acids; Lewis bases; Nickel; Nucleophiles; Oxidation; Reaction mechanisms; State-of-the-art reviews

Transformation of sterically hindered tertiary alkyl electrophiles under nickel-catalyzed conditions to forge C(sp 3 )-C bonds and simultaneously create challenging all-carbon quaternary centers has received growing attention in the recent years. The unique nature of nickel featuring flexible oxidat...