Comparison of the efficacy and tolerability of preservative-free and preservative-containing formulations of the dorzolamide/timolol fixed combination (COSOPT™) in patients with elevated intraocular pressure in a randomized clinical trial

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 248; no. 12; pp. 1757 - 1764
• Main Authors: Shedden, Arthur, Adamsons, Ingrid A., Getson, Albert J., Laurence, Jean K., Lines, Christopher R., Hewitt, David J., Ho, Tony W.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.12.2010; Springer Nature B.V
• Subjects: Antihypertensive Agents - administration & dosage; Antihypertensive Agents - therapeutic use; Double-Blind Method; Drug Combinations; Female; Glaucoma; Glaucoma, Open-Angle - drug therapy; Humans; Intraocular Pressure - drug effects; Male; Medicine; Medicine & Public Health; Middle Aged; Ocular Hypertension - drug therapy; Ophthalmology; Preservatives, Pharmaceutical - adverse effects; Preservatives, Pharmaceutical - therapeutic use; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Thiophenes - adverse effects; Thiophenes - therapeutic use; Timolol - adverse effects; Timolol - therapeutic use; Tonometry, Ocular; Treatment Outcome; Glaucoma; Dorzolamide; Ocular hypertension; COSOPT; Benzalkonium chloride; Timolol; Intraocular pressure

Background The aim of this study was to compare the efficacy and tolerability of preservative-free (PF) and preservative-containing (PC) formulations of the dorzolamide/timolol fixed combination (COSOPT™) in patients with elevated intraocular pressure (IOP). Methods A parallel, randomized, double-ma...