Is ADHD a Risk Factor Independent of Conduct Disorder for Illicit Substance Use? A Meta-Analysis and Metaregression Investigation

Objective: To investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct disorder/oppositional-defiant disorder (CD/ODD). Method: A systematic literature review was conducted through Medline from 1980 to 2008. Data extract...

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Published inJournal of attention disorders Vol. 17; no. 6; pp. 459 - 469
Main Authors Serra-Pinheiro, Maria Antonia, Coutinho, Evandro S. F., Souza, Isabella S., Pinna, Camilla, Fortes, Dídia, Araújo, Catia, Szobot, Claudia M., Rohde, Luis A., Mattos, Paulo
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.08.2013
Subjects
Attention Deficit Disorder with Hyperactivity - epidemiology
Comorbidity
Conduct Disorder - epidemiology
Humans
Odds Ratio
Regression Analysis
Risk Factors
Substance-Related Disorders - epidemiology
ADHD
comorbidity
conduct disorder
substance
drug
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Abstract Objective: To investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct disorder/oppositional-defiant disorder (CD/ODD). Method: A systematic literature review was conducted through Medline from 1980 to 2008. Data extracted and selections made by one author were reviewed by another. Results: Fifteen articles presented odds ratios (ORs) for the development of ISU in individuals with ADHD controlling for CD/ODD. In total, the study covered results for more than 1,000 individuals. The combined OR for studies that included in their analysis exclusively ISU was 1.35 (0.90-2.03), p = .15, heterogeneity = 55%. Lack of control for socioeconomic status was related with a weaker association between ADHD and ISU. Conclusion: The existing data do not indicate that ADHD increases the risk of ISU beyond the effects of CD/ODD. However, the combination of all existing data is limited in power to detect a small increase in chance.
AbstractList To investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct disorder/oppositional-defiant disorder (CD/ODD). A systematic literature review was conducted through Medline from 1980 to 2008. Data extracted and selections made by one author were reviewed by another. Fifteen articles presented odds ratios (ORs) for the development of ISU in individuals with ADHD controlling for CD/ODD. In total, the study covered results for more than 1,000 individuals. The combined OR for studies that included in their analysis exclusively ISU was 1.35 (0.90-2.03), p = .15, heterogeneity = 55%. Lack of control for socioeconomic status was related with a weaker association between ADHD and ISU. The existing data do not indicate that ADHD increases the risk of ISU beyond the effects of CD/ODD. However, the combination of all existing data is limited in power to detect a small increase in chance.
OBJECTIVETo investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct disorder/oppositional-defiant disorder (CD/ODD).METHODA systematic literature review was conducted through Medline from 1980 to 2008. Data extracted and selections made by one author were reviewed by another.RESULTSFifteen articles presented odds ratios (ORs) for the development of ISU in individuals with ADHD controlling for CD/ODD. In total, the study covered results for more than 1,000 individuals. The combined OR for studies that included in their analysis exclusively ISU was 1.35 (0.90-2.03), p = .15, heterogeneity = 55%. Lack of control for socioeconomic status was related with a weaker association between ADHD and ISU.CONCLUSIONThe existing data do not indicate that ADHD increases the risk of ISU beyond the effects of CD/ODD. However, the combination of all existing data is limited in power to detect a small increase in chance.
Objective: To investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct disorder/oppositional-defiant disorder (CD/ODD). Method: A systematic literature review was conducted through Medline from 1980 to 2008. Data extracted and selections made by one author were reviewed by another. Results: Fifteen articles presented odds ratios (ORs) for the development of ISU in individuals with ADHD controlling for CD/ODD. In total, the study covered results for more than 1,000 individuals. The combined OR for studies that included in their analysis exclusively ISU was 1.35 (0.90-2.03), p = .15, heterogeneity = 55%. Lack of control for socioeconomic status was related with a weaker association between ADHD and ISU. Conclusion: The existing data do not indicate that ADHD increases the risk of ISU beyond the effects of CD/ODD. However, the combination of all existing data is limited in power to detect a small increase in chance.
Author Rohde, Luis A.
Coutinho, Evandro S. F.
Serra-Pinheiro, Maria Antonia
Szobot, Claudia M.
Souza, Isabella S.
Pinna, Camilla
Mattos, Paulo
Fortes, Dídia
Araújo, Catia
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22344318$$D View this record in MEDLINE/PubMed
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comorbidity
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    fullname: Johnston L. D.
– ident: bibr45-1087054711435362
  doi: 10.1207/s15374424jccp3502_5
– volume: 1
  start-page: 121
  year: 1996
  ident: bibr38-1087054711435362
  publication-title: Molecular Psychiatry
  contributor:
    fullname: LaHoste G. J.
– ident: bibr56-1087054711435362
  doi: 10.1016/j.drugalcdep.2006.12.010
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Snippet Objective: To investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct...
To investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct...
OBJECTIVETo investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct...
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StartPage 459
SubjectTerms Attention Deficit Disorder with Hyperactivity - epidemiology
Comorbidity
Conduct Disorder - epidemiology
Humans
Odds Ratio
Regression Analysis
Risk Factors
Substance-Related Disorders - epidemiology
Title Is ADHD a Risk Factor Independent of Conduct Disorder for Illicit Substance Use? A Meta-Analysis and Metaregression Investigation
URI https://journals.sagepub.com/doi/full/10.1177/1087054711435362
https://www.ncbi.nlm.nih.gov/pubmed/22344318
https://search.proquest.com/docview/1411628983
https://search.proquest.com/docview/1419368974
Volume 17
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