Tumor Growth Inhibitory and Natural Suppressor Activities of Murine Bone Marrow Cells: A Comparative Study

• Published in: Cellular immunology Vol. 182; no. 1; pp. 12 - 19
• Main Authors: Seledtsov, Victor I., Taraban, Vadim Y., Seledtsova, Galina V., Samarin, Denis M., Avdeev, Ilias V., Senyukov, Vladimir V., Kozlov, Vladimir A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 25.11.1997
• Subjects: Animals; B-Lymphocytes - immunology; bone marrow cell; Bone Marrow Cells - immunology; Cell Communication - immunology; Culture Media, Conditioned; Cytotoxicity, Immunologic; Female; Immunity, Innate; In Vitro Techniques; Interferon-gamma - immunology; Lymphocyte Activation; Lymphokines - immunology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Nude; natural suppression; T-Lymphocytes - immunology; T-Lymphocytes, Regulatory - immunology; Tumor Cells, Cultured; tumor growth inhibition; WGA, wheat germ agglutinin; CM, conditioned medium; Con, concanavalin; Ab, Antibody (antibodies)BM, bone marrow; NS, natural suppressor; LME, l-leucyl methyl ester; LMMA, NG-monomethyl-l-arginine; IFN, interferon, IL, interleukin; D-PBS, Dulbecco's phosphate-buffered saline; tumor growth inhibition; natural suppression; LPS, lipopolysaccharide; bone marrow cell; DMMA,NG -monomethyl-d-arginine; FCS, fetal calf serum

The murine bone marrow (BM) cells having a certain phenotypic similarity to null natural suppressor (NS) cells have been previously established to be able to inhibitin vitroleukemic cell growth in a genetically unrestricted manner. In this study we found that the treatment of normal (C57BL/6 × DBA)F...