Comparative Genomics of Carriage and Disease Isolates of Streptococcus pneumoniae Serotype 22F Reveals Lineage-Specific Divergence and Niche Adaptation

• Published in: Genome biology and evolution Vol. 8; no. 4; pp. 1243 - 1251
• Main Authors: Cleary, David W, Devine, Vanessa T, Jefferies, Johanna M C, Webb, Jeremy S, Bentley, Stephen D, Gladstone, Rebecca A, Faust, Saul N, Clarke, Stuart C
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2016
• Subjects: Amidohydrolases - genetics; Anti-Bacterial Agents - pharmacology; Bacterial Proteins - genetics; Child; Drug Resistance, Microbial; Female; Genome Report; Genome, Bacterial; Genomic Islands; Genomics; Genomics - methods; Humans; Male; Middle Aged; Mutation; Pneumococcal Infections - drug therapy; Pneumococcal Infections - microbiology; Streptococcus infections; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - isolation & purification; Streptococcus pneumoniae - pathogenicity; Virulence Factors - genetics; genome sequencing; invasive pneumococcal disease; Streptococcus pneumoniae

Streptococcus pneumoniae is a major cause of meningitis, sepsis, and pneumonia worldwide. Pneumococcal conjugate vaccines have been part of the United Kingdom's childhood immunization program since 2006 and have significantly reduced the incidence of disease due to vaccine efficacy in reducing...