A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds

• Published in: Chemical communications (Cambridge, England) Vol. 55; no. 6; pp. 8816 - 8819
• Main Authors: Gao, Qianwen, Liu, Ze-Shui, Hua, Yu, Li, Lisha, Cheng, Hong-Gang, Cong, Hengjiang, Zhou, Qianghui
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 23.07.2019; Royal Society of Chemistry
• Subjects: amination; Aromatic compounds; Catalysis; catalytic activity; Chemical reactions; Chemistry; Chemistry, Multidisciplinary; chemoselectivity; Crystallography; Enantiomers; enantioselectivity; Iodides; Organic chemistry; organoiodine compounds; Palladium; Physical Sciences; Reagents; Scaffolds; Science & Technology; Substrates; AROMATIC FUNCTIONALIZATION; SEQUENTIAL REACTIONS; PALLADIUM; NORBORNENE; PD; ALPHA-ARYLATION; ARYL IODIDES; CATELLANI REACTION; C-H FUNCTIONALIZATION; TETRASUBSTITUTED HELICAL ALKENES

A palladium/norbornene cooperative catalysis promoted annulation involving an ortho -C-H amination and intramolecular Heck cascade between aryl iodides and functionalized amination reagents is reported, thereby providing a highly convergent access to the unique N-containing bridged scaffolds: hexahy...