Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms

• Published in: Food chemistry Vol. 135; no. 4; pp. 2350 - 2358
• Main Authors: Kang, Changkeun, Lee, Hyunkyoung, Jung, Eun-Sun, Seyedian, Ramin, Jo, MiNa, Kim, Jehein, Kim, Jong-Shu, Kim, Euikyung
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15.12.2012; Elsevier
• Subjects: acetyl-CoA carboxylase; action potentials; AMP-activated protein kinase; AMP-Activated Protein Kinases; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; AMPK; Animals; Aroma and flavouring agent industries; Biological and medical sciences; Biological Transport; Biological Transport - drug effects; Cell Line; chemistry; Crocus; Crocus - chemistry; Crocus sativus; cytology; Diabetes Mellitus; Diabetes Mellitus - genetics; Diabetes Mellitus - metabolism; drug effects; Food industries; Fundamental and applied biological sciences. Psychology; genetics; glucose; Glucose - metabolism; Glucose Transporter Type 4; Glucose Transporter Type 4 - genetics; Glucose Transporter Type 4 - metabolism; Glucose uptake; Humans; Insulin Resistance; Insulin sensitivity; MAP Kinase Signaling System; MAP Kinase Signaling System - drug effects; mechanism of action; metabolism; Mice; mitogen-activated protein kinase; Muscle Cells; Muscle Cells - drug effects; Muscle Cells - metabolism; Muscle, Skeletal; Muscle, Skeletal - cytology; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; myocytes; pharmacology; phosphatidylinositol 3-kinase; Plant Extracts; Plant Extracts - pharmacology; Saffron; skeletal muscle; Skeletal muscle cells; Up-Regulation; Up-Regulation - drug effects; AMPK; Glucose uptake; Saffron; Skeletal muscle cells; Insulin sensitivity; Iridaceae; Monocotyledones; Crocus sativus; Spice; Glucose; Insulin; Uptake; Mechanism; Sensitivity; Angiospermae; Carbohydrate; Spermatophyta; Muscle
• ISSN: 0308-8146; 1873-7072; 1873-7072
• DOI: 10.1016/j.foodchem.2012.06.092

► AMP-activated protein kinase (AMPK) has a key role in glucose metabolism of muscle. ► The activation of AMPK leads to GLUT4 translocation and glucose uptake in muscle. ► Saffron treatment stimulates glucose uptake via AMPK/ACC and MAPKs pathways. ► Saffron and insulin have a synergistic effect on...