A Strategy for Detecting Absorbed Bioactive Compounds for Quality Control in the Water Extract of Rhubarb by Ultra Performance Liquid Chromatography with Photodiode Array Detector

• Published in: Chinese journal of integrative medicine Vol. 18; no. 9; pp. 690 - 698
• Main Author: 王杨 黄熙 梁清华 范荣 秦锋 呙勇 闫奎坡 刘维 罗杰坤 李云辉 毛喜莲 刘昭前 周宏灏
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Association of Traditional and Western Medicine 01.09.2012
• Subjects: Absorption - drug effects; Animals; Anthraquinones - cerebrospinal fluid; Anthraquinones - chemistry; Biological Products - analysis; Biological Products - cerebrospinal fluid; Biological Products - chemistry; Brain Injuries - drug therapy; Brain Injuries - pathology; Chromatography, Liquid - instrumentation; Chromatography, Liquid - methods; Emodin - administration & dosage; Emodin - analogs & derivatives; Emodin - pharmacology; Emodin - therapeutic use; Humans; Limit of Detection; Linear Models; Male; Medicine; Medicine & Public Health; Original Article; Plant Extracts - chemistry; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Rheum - chemistry; Water - chemistry; 人体吸收; 光电二极管阵列检测器; 水提取物; 生物活性化合物; 芦荟大黄素; 质量控制; 超氧化物歧化酶活性; 超高效液相色谱; craniocerebral injury; rhubarb; absorbed bioactive compounds; anthraquinones; quality control; ultra performance liquid chromatography

Objective： To detect absorbed bioactive compounds of the water extract whose pharmacodynamic effect was craniocerebral protection for quality control assessment. Methods： Anthraquinones in water extract of rhubarb （WER）, in cerebrospinal fluid （CSF） of patients with traumatic brain injury （TBI） and...