Effect of Traditional and Integrative Regimens on Quality of Life and Early Renal Impairment in Elderly Patients with Isolated Systolic Hypertension
Objective：To observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension（EISH）.Methods： A multi-center,randomized,double-blinded controlled trail was adopted.A total of 270 cases o...
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| Published in | Chinese journal of integrative medicine Vol. 16; no. 3; pp. 216 - 221 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Chinese Association of Traditional and Western Medicine
01.06.2010
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| Online Access | Get full text |
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| Abstract | Objective：To observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension（EISH）.Methods： A multi-center,randomized,double-blinded controlled trail was adopted.A total of 270 cases of EISH were randomly divided into 3 groups：Chinese medicine group（CM）,combination group and Western medicine group （WM）.The course of treatment was 4 weeks.The clinical blood pressure,integral of quality of life（SF-36 scale）, immunoglubin G（IgG）,microalbumin（mALB）,β_2-microglobulin（β_2-MG）,transferrin（TRF）and N-acetyl-β＇- D-glucosa-minidase（NAG）in urine were determined before and after the treatment.Results：After treatment, systolic blood pressure depressed significantly in each group（P〈0.05）,and the combination group was superior to CM or WM group in depressing SBP（P〈0.05）; in each group,integral of quality of life improved in different degree,and combination group was superior to WM group in all 8 dimensions（P〈0.05）.The level of mALB andβ_2-MG in urine decreased in all groups（P〈0.05）,and the combination group was superior to CM group or WM group in decreasing mALB（P〈0.05）.Conclusions：Chinese medical regimen has affirmative effect in treating EISH patients,and could lower the systolic blood pressure,improve quality of life and early renal impairment of the patients,and integrative medical regimen has superiority on account of cooperation,and deserves further study. |
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| AbstractList | To observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension (EISH).
A multi-center, randomized, double-blinded controlled trail was adopted. A total of 270 cases of EISH were randomly divided into 3 groups: Chinese medicine group (CM), combination group and Western medicine group (WM). The course of treatment was 4 weeks. The clinical blood pressure, integral of quality of life (SF-36 scale), immunoglubin G (IgG), microalbumin (mALB), beta(2)-microglobulin (beta(2)-MG), transferrin (TRF) and N-acetyl-beta'-D-glucosa-minidase (NAG) in urine were determined before and after the treatment.
After treatment, systolic blood pressure depressed significantly in each group (P<0.05), and the combination group was superior to CM or WM group in depressing SBP (P<0.05); in each group, integral of quality of life improved in different degree, and combination group was superior to WM group in all 8 dimensions (P<0.05). The level of mALB and beta(2)-MG in urine decreased in all groups (P<0.05), and the combination group was superior to CM group or WM group in decreasing mALB (P<0.05).
Chinese medical regimen has affirmative effect in treating EISH patients, and could lower the systolic blood pressure, improve quality of life and early renal impairment of the patients, and integrative medical regimen has superiority on account of cooperation, and deserves further study. Objective：To observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension（EISH）.Methods： A multi-center,randomized,double-blinded controlled trail was adopted.A total of 270 cases of EISH were randomly divided into 3 groups：Chinese medicine group（CM）,combination group and Western medicine group （WM）.The course of treatment was 4 weeks.The clinical blood pressure,integral of quality of life（SF-36 scale）, immunoglubin G（IgG）,microalbumin（mALB）,β_2-microglobulin（β_2-MG）,transferrin（TRF）and N-acetyl-β＇- D-glucosa-minidase（NAG）in urine were determined before and after the treatment.Results：After treatment, systolic blood pressure depressed significantly in each group（P〈0.05）,and the combination group was superior to CM or WM group in depressing SBP（P〈0.05）; in each group,integral of quality of life improved in different degree,and combination group was superior to WM group in all 8 dimensions（P〈0.05）.The level of mALB andβ_2-MG in urine decreased in all groups（P〈0.05）,and the combination group was superior to CM group or WM group in decreasing mALB（P〈0.05）.Conclusions：Chinese medical regimen has affirmative effect in treating EISH patients,and could lower the systolic blood pressure,improve quality of life and early renal impairment of the patients,and integrative medical regimen has superiority on account of cooperation,and deserves further study. Objective To observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension (EISH). Methods A multi-center, randomized, double-blinded controlled trail was adopted. A total of 270 cases of EISH were randomly divided into 3 groups: Chinese medicine group (CM), combination group and Western medicine group (WM). The course of treatment was 4 weeks. The clinical blood pressure, integral of quality of life (SF-36 scale), immunoglubin G (IgG), microalbumin (mALB), β 2 -microglobulin (β 2 -MG), transferrin (TRF) and N-acetyl-β′-D-glucosa-minidase (NAG) in urine were determined before and after the treatment. Results After treatment, systolic blood pressure depressed significantly in each group ( P <0.05), and the combination group was superior to CM or WM group in depressing SBP ( P <0.05); in each group, integral of quality of life improved in different degree, and combination group was superior to WM group in all 8 dimensions ( P <0.05). The level of mALB and β 2 -MG in urine decreased in all groups ( P <0.05), and the combination group was superior to CM group or WM group in decreasing mALB ( P <0.05). Conclusions Chinese medical regimen has affirmative effect in treating EISH patients, and could lower the systolic blood pressure, improve quality of life and early renal impairment of the patients, and integrative medical regimen has superiority on account of cooperation, and deserves further study. OBJECTIVETo observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension (EISH). METHODSA multi-center, randomized, double-blinded controlled trail was adopted. A total of 270 cases of EISH were randomly divided into 3 groups: Chinese medicine group (CM), combination group and Western medicine group (WM). The course of treatment was 4 weeks. The clinical blood pressure, integral of quality of life (SF-36 scale), immunoglubin G (IgG), microalbumin (mALB), beta(2)-microglobulin (beta(2)-MG), transferrin (TRF) and N-acetyl-beta'-D-glucosa-minidase (NAG) in urine were determined before and after the treatment. RESULTSAfter treatment, systolic blood pressure depressed significantly in each group (P<0.05), and the combination group was superior to CM or WM group in depressing SBP (P<0.05); in each group, integral of quality of life improved in different degree, and combination group was superior to WM group in all 8 dimensions (P<0.05). The level of mALB and beta(2)-MG in urine decreased in all groups (P<0.05), and the combination group was superior to CM group or WM group in decreasing mALB (P<0.05). CONCLUSIONSChinese medical regimen has affirmative effect in treating EISH patients, and could lower the systolic blood pressure, improve quality of life and early renal impairment of the patients, and integrative medical regimen has superiority on account of cooperation, and deserves further study. |
| Author | 李浩 刘龙涛 赵文明 刘剑刚 姚明江 韩永祥 沈雁朋 刘兴东 刘丽 王雪梅 蔡琳琳 官杰 |
| AuthorAffiliation | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing （100091）, China Traditional Chinese Medicine Hospital of Yanqing County, Beijing （102100）, China Community Health Service Centers of Yanqing County, Beijing （102100）, China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20694775$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_ctim_2015_04_002 crossref_primary_10_1155_2012_284847 crossref_primary_10_1007_s11655_015_2093_6 crossref_primary_10_1155_2013_275279 crossref_primary_10_1155_2013_978398 crossref_primary_10_1155_2012_271462 crossref_primary_10_1038_hr_2013_18 crossref_primary_10_1007_s11655_010_0549_2 crossref_primary_10_1155_2013_706125 crossref_primary_10_1155_2012_714805 crossref_primary_10_1093_jpp_rgaa062 crossref_primary_10_2174_1389200221666200514121501 crossref_primary_10_1080_00498254_2021_2023787 crossref_primary_10_1371_journal_pone_0272071 |
| Cites_doi | 10.1056/NEJMcp071137 10.1097/00005650-199206000-00002 10.1001/jama.289.19.2560 10.1093/ndt/gfg080 10.47102/annals-acadmedsg.V34N1p8 |
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| References_xml | – start-page: 20 year: 2006 ident: CR3 publication-title: China guideline for the prevention and Treatment of hypertension in 2005 – volume: 357 start-page: 789 year: 2007 end-page: 796 ident: CR6 article-title: Clinical practice Isolated systolic hypertension in the elderly publication-title: N Engl J Med doi: 10.1056/NEJMcp071137 contributor: fullname: Chobanian – volume: 6 start-page: 1265 year: 2008 end-page: 1267 ident: CR10 article-title: The clinical research of traditional and West integrative medical treatment of the renal damage of hypertension publication-title: Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) contributor: fullname: Tang – volume: 15 start-page: 76 year: 2007 end-page: 77 ident: CR11 article-title: The detection value of urinary protein and urinary enzyme for early diagnosis of renal damage of hypertensive publication-title: Chin Health Med (Chin) contributor: fullname: Sun – volume: 12 start-page: 828 year: 2006 end-page: 829 ident: CR1 article-title: The detection methods of the early renal disease of hypertension publication-title: Med Recapitulate (Chin) contributor: fullname: Li – volume: 30 start-page: 473 year: 1992 end-page: 483 ident: CR5 article-title: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection publication-title: Med Care doi: 10.1097/00005650-199206000-00002 contributor: fullname: Sherbourne – volume: 3 start-page: 25 year: 2006 end-page: 26 ident: CR8 article-title: The clinical application of urinary albumin detection on the diagnosis of early renal damage of hypertension publication-title: Lab Med Clin (Chin) contributor: fullname: Chen – volume: 45 start-page: 26 year: 2004 end-page: 28 ident: CR4 article-title: Clinical study on Jiangya Capsules for treatment of 24 cases of senile simple systolic hypertension publication-title: J Tradit Chin Med (Chin) contributor: fullname: Luo – volume: 289 start-page: 2560 year: 2003 end-page: 2572 ident: CR2 article-title: Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report publication-title: JAMA doi: 10.1001/jama.289.19.2560 contributor: fullname: Izzo – volume: 34 start-page: 8 year: 2005 end-page: 15 ident: CR7 article-title: Progression of renal failure — the role of hypertension publication-title: Ann Acad Med Singapore contributor: fullname: Whitworth – volume: 18 start-page: 892 year: 2003 end-page: 898 ident: CR9 article-title: Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfg080 contributor: fullname: Stehouwer – volume: 6 start-page: 1265 year: 2008 ident: 216_CR10 publication-title: Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) contributor: fullname: M.F. Tang – volume: 357 start-page: 789 year: 2007 ident: 216_CR6 publication-title: N Engl J Med doi: 10.1056/NEJMcp071137 contributor: fullname: A.V. Chobanian – volume: 15 start-page: 76 year: 2007 ident: 216_CR11 publication-title: Chin Health Med (Chin) contributor: fullname: L.L. Wan – volume: 12 start-page: 828 year: 2006 ident: 216_CR1 publication-title: Med Recapitulate (Chin) contributor: fullname: J.Y. Yu – volume: 30 start-page: 473 year: 1992 ident: 216_CR5 publication-title: Med Care doi: 10.1097/00005650-199206000-00002 contributor: fullname: J.E. Ware Jr – volume: 3 start-page: 25 year: 2006 ident: 216_CR8 publication-title: Lab Med Clin (Chin) contributor: fullname: X.C. Zhang – volume: 34 start-page: 8 year: 2005 ident: 216_CR7 publication-title: Ann Acad Med Singapore doi: 10.47102/annals-acadmedsg.V34N1p8 contributor: fullname: J.A. Whitworth – volume: 18 start-page: 892 year: 2003 ident: 216_CR9 publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfg080 contributor: fullname: F. Stam – volume: 45 start-page: 26 year: 2004 ident: 216_CR4 publication-title: J Tradit Chin Med (Chin) contributor: fullname: H. Li – volume: 289 start-page: 2560 year: 2003 ident: 216_CR2 publication-title: JAMA doi: 10.1001/jama.289.19.2560 contributor: fullname: A.V. Chobanian – start-page: 20 volume-title: China guideline for the prevention and Treatment of hypertension in 2005 year: 2006 ident: 216_CR3 contributor: fullname: Amendment Committee of Chinese PreventionTreatment of Hypertension. |
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| SubjectTerms | Aged Aged, 80 and over Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Female Humans Hypertension - drug therapy Hypertension - physiopathology Integrative Medicine Kidney - drug effects Kidney - pathology Kidney - physiopathology Male Medicine Medicine & Public Health Original Article Quality of Life Systole - drug effects Systole - physiology 收缩压 治疗方案 生活质量 老年病 高血压 |
| Title | Effect of Traditional and Integrative Regimens on Quality of Life and Early Renal Impairment in Elderly Patients with Isolated Systolic Hypertension |
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