Distinct Gene Expression Profiles Directed by the Isoforms of the Transcription Factor Neuron-Restrictive Silencer Factor in Human SK-N-AS Neuroblastoma Cells

• Published in: Journal of molecular neuroscience Vol. 44; no. 2; pp. 77 - 90
• Main Authors: Gillies, Stuart G., Haddley, Kate, Vasiliou, Sylvia A., Jacobson, Gregory M., von Mentzer, Bengt, Bubb, Vivien J., Quinn, John P.
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 01.06.2011; Springer Nature B.V
• Subjects: Anticonvulsants; Anticonvulsants - pharmacology; Anticonvulsants - therapeutic use; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Cell Biology; Cell Line; Epigenetics; Epilepsy; Epilepsy - drug therapy; Epilepsy - genetics; Epilepsy - metabolism; Gene expression; Gene Expression Profiling; Humans; Microarray Analysis; Neuroblastoma; Neuroblastoma - genetics; Neuroblastoma - metabolism; Neurochemistry; Neurology; Neurosciences; Polymerase chain reaction; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proteins; Proteomics; Repressor Proteins - genetics; Repressor Proteins - metabolism; Signal transduction; Transcription factors; REST; NRSF; Microarray; Gene expression; Epilepsy

Neuron-restrictive silencer factor (NRSF) and its isoforms are differentially regulated in rodent models of self-sustaining status epilepticus (SSSE). NRSF isoforms regulate genes associated with SSSE, including the proconvulsant tachykinins, brain-derived neurotrophic factor and multiple ion channe...