The insertion of human apolipoprotein H into phospholipid membranes: a monolayer study

• Published in: Biochemical journal Vol. 335 ( Pt 2); no. 2; pp. 225 - 232
• Main Authors: Wang, S X, Cai, G P, Sui, S F
• Format: Journal Article
• Language: English
• Published: England 15.10.1998
• Subjects: 1,2-Dipalmitoylphosphatidylcholine - chemistry; 1,2-Dipalmitoylphosphatidylcholine - metabolism; Air; beta 2-Glycoprotein I; Calcium - chemistry; Calcium - pharmacology; Glycoproteins - chemistry; Glycoproteins - drug effects; Glycoproteins - metabolism; Hot Temperature; Humans; Hydrogen-Ion Concentration; Magnesium - chemistry; Magnesium - pharmacology; Membrane Lipids - chemistry; Membrane Lipids - metabolism; Phosphatidylserines - chemistry; Phosphatidylserines - metabolism; Phospholipids - chemistry; Phospholipids - metabolism; Sodium Chloride - chemistry; Sodium Chloride - pharmacology; Structure-Activity Relationship; Surface Properties; Water

Apolipoprotein H (ApoH) is a plasma glycoprotein isolated from human serum. The interactions of ApoH with lipid membrane were reported to be essential for its physiological and pathogenic roles. In this paper we studied the ability of ApoH to insert into phospholipid membranes using the monolayer ap...