Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway
Diabetic neuropathy (DN) is a common neurological complication caused by diabetes mellitus (DM). Axonal degeneration is generally accepted to be the major pathological change in peripheral DN. Taurine has been evidenced to be neuroprotective in various aspects, but its effect on spinal cord axon inj...
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| Published in | Amino acids Vol. 56; no. 1; p. 32 |
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| Abstract | Diabetic neuropathy (DN) is a common neurological complication caused by diabetes mellitus (DM). Axonal degeneration is generally accepted to be the major pathological change in peripheral DN. Taurine has been evidenced to be neuroprotective in various aspects, but its effect on spinal cord axon injury (SCAI) in DN remains barely reported. This study showed that taurine significantly ameliorated axonal damage of spinal cord (SC), based on morphological and functional analyses, in a rat model of DN induced by streptozotocin (STZ). Taurine was also found to induce neurite outgrowth in cultured cerebral cortex neurons with high glucose exposure. Moreover, taurine up-regulated the expression of nerve growth factor (NGF) and neurite outgrowth relative protein GAP-43 in rat DN model and cultured cortical neurons/VSC4.1 cells. Besides, taurine increased the activating phosphorylation signals of TrkA, Akt, and mTOR. Mechanistically, the neuroprotection by taurine was related to the NGF–pAKT–mTOR axis, because either NGF-neutralizing antibody or Akt or mTOR inhibitors was found to attenuate its beneficial effects. Together, our results demonstrated that taurine promotes spinal cord axon repair in a model of SCAI in STZ-induced diabetic rats, mechanistically associating with the NGF-dependent activation of Akt/mTOR pathway. |
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| AbstractList | Diabetic neuropathy (DN) is a common neurological complication caused by diabetes mellitus (DM). Axonal degeneration is generally accepted to be the major pathological change in peripheral DN. Taurine has been evidenced to be neuroprotective in various aspects, but its effect on spinal cord axon injury (SCAI) in DN remains barely reported. This study showed that taurine significantly ameliorated axonal damage of spinal cord (SC), based on morphological and functional analyses, in a rat model of DN induced by streptozotocin (STZ). Taurine was also found to induce neurite outgrowth in cultured cerebral cortex neurons with high glucose exposure. Moreover, taurine up-regulated the expression of nerve growth factor (NGF) and neurite outgrowth relative protein GAP-43 in rat DN model and cultured cortical neurons/VSC4.1 cells. Besides, taurine increased the activating phosphorylation signals of TrkA, Akt, and mTOR. Mechanistically, the neuroprotection by taurine was related to the NGF–pAKT–mTOR axis, because either NGF-neutralizing antibody or Akt or mTOR inhibitors was found to attenuate its beneficial effects. Together, our results demonstrated that taurine promotes spinal cord axon repair in a model of SCAI in STZ-induced diabetic rats, mechanistically associating with the NGF-dependent activation of Akt/mTOR pathway. Abstract Diabetic neuropathy (DN) is a common neurological complication caused by diabetes mellitus (DM). Axonal degeneration is generally accepted to be the major pathological change in peripheral DN. Taurine has been evidenced to be neuroprotective in various aspects, but its effect on spinal cord axon injury (SCAI) in DN remains barely reported. This study showed that taurine significantly ameliorated axonal damage of spinal cord (SC), based on morphological and functional analyses, in a rat model of DN induced by streptozotocin (STZ). Taurine was also found to induce neurite outgrowth in cultured cerebral cortex neurons with high glucose exposure. Moreover, taurine up-regulated the expression of nerve growth factor (NGF) and neurite outgrowth relative protein GAP-43 in rat DN model and cultured cortical neurons/VSC4.1 cells. Besides, taurine increased the activating phosphorylation signals of TrkA, Akt, and mTOR. Mechanistically, the neuroprotection by taurine was related to the NGF–pAKT–mTOR axis, because either NGF-neutralizing antibody or Akt or mTOR inhibitors was found to attenuate its beneficial effects. Together, our results demonstrated that taurine promotes spinal cord axon repair in a model of SCAI in STZ-induced diabetic rats, mechanistically associating with the NGF-dependent activation of Akt/mTOR pathway. |
| ArticleNumber | 32 |
| Author | Chen, Xiaochi Wang, Yachen Zhang, Cong Gao, Bihu Piao, Fengyuan Li, Shuangyue Shi, Xiaoxia Zhang, Qing |
| Author_xml | – sequence: 1 givenname: Yachen surname: Wang fullname: Wang, Yachen organization: Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University – sequence: 2 givenname: Bihu surname: Gao fullname: Gao, Bihu organization: Department of Nephrology, Affiliated Zhongshan Hospital of Dalian University, Department of Urology, The First Affiliated Hospital of Dalian Medical University – sequence: 3 givenname: Xiaochi surname: Chen fullname: Chen, Xiaochi organization: Department of Urology, The First Affiliated Hospital of Dalian Medical University – sequence: 4 givenname: Xiaoxia surname: Shi fullname: Shi, Xiaoxia organization: Department of Occupational and Environmental Health, Dalian Medical University – sequence: 5 givenname: Shuangyue surname: Li fullname: Li, Shuangyue organization: Department of Occupational and Environmental Health, Dalian Medical University – sequence: 6 givenname: Qing surname: Zhang fullname: Zhang, Qing email: zhangqing@dlu.edu.cn organization: Department of Integrative Laboratory, Affiliated Zhongshan Hospital of Dalian University – sequence: 7 givenname: Cong surname: Zhang fullname: Zhang, Cong email: congzhang1203@hotmail.com organization: Department of Nutrition and Food Safety, Dalian Medical University – sequence: 8 givenname: Fengyuan surname: Piao fullname: Piao, Fengyuan email: piao_fy_dy@163.com organization: Department of Scientific Research Project, Affiliated Zhongshan Hospital of Dalian University |
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| Cites_doi | 10.1016/j.neulet.2016.07.032 10.4103/1673-5374.335830 10.2337/db23-0006 10.1016/S0140-6736(00)05268-5 10.1038/s41420-021-00701-y 10.1038/s41572-019-0092-1 10.1016/S0006-8993(00)02995-4 10.1089/neu.2019.6604 10.2337/db19-0321 10.1007/s00726-021-02957-1 10.3389/fncir.2014.00006 10.1038/srep34715 10.1016/j.toxlet.2012.09.019 10.1007/s12640-021-00341-1 10.1007/978-981-13-8023-5_65 10.1038/s41467-023-36680-0 10.1016/j.diabres.2017.03.024 10.3892/etm.2017.4516 10.1016/j.mcn.2017.04.011 10.1016/S0304-3940(97)13383-3 10.1093/jb/mvn064 10.1016/j.brainres.2017.12.016 10.1371/journal.pone.0179388 10.2337/dc06-0650 10.1016/j.expneurol.2012.10.002 10.1007/s11011-014-9572-x 10.1007/s11064-006-9225-5 10.1212/WNL.43.4.817 10.1093/brain/awr280 10.1186/s12974-018-1224-3 10.1186/1758-5996-2-46 10.1155/2020/1295492 10.1172/JCI88321 10.1155/2013/149452 10.1292/jvms.12-0149 10.1016/j.yexcr.2019.111557 10.1038/nrneurol.2010.90 10.3389/fnins.2018.00558 10.1007/s00726-012-1382-z 10.1136/bmj.1.2246.122 10.1016/j.acthis.2018.09.008 10.1016/j.nbd.2006.01.012 10.2147/IJNRD.S103784 10.1016/j.expneurol.2009.12.032 10.1007/s12272-022-01391-5 10.1038/aps.2012.59 10.1016/j.cbi.2023.110402 10.1006/exnr.2001.7789 10.1016/j.neulet.2003.12.012 10.1016/j.dsx.2014.05.001 10.1007/s00726-019-02810-6 10.1016/S0736-5748(00)00040-X 10.1186/1423-0127-17-S1-S2 10.1097/j.pain.0000000000000465 10.1007/BF01241031 10.1016/j.nutres.2024.01.014 10.1002/syn.22219 10.1038/s41598-017-05051-3 10.1006/exnr.1999.7166 10.2337/diacare.28.4.956 10.3390/ijms221810123 10.1007/s00726-018-2544-4 10.1016/j.brainres.2014.08.048 10.3390/ijms21207485 10.1038/ncb895 |
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| Keywords | Taurine Diabetic neuropathy Nerve growth factor Diabetes mellitus Spinal cord axon injury |
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| References | ZhangMShiXLuoMLanQUllahHZhangCLiSChenXWangYPiaoFTaurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathwayAmino Acids2021533954061:CAS:528:DC%2BB3MXktlGhu70%3D10.1007/s00726-021-02957-1 LiMXWengJWHoESChowSFTsangCKBrain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injuryNeural Regen Res202217215721651:CAS:528:DC%2BB3sXhsFaqsL%2FO908317610.4103/1673-5374.335830 MuramatsuKDiabetes mellitus-related dysfunction of the motor systemInt J Mol Sci20202174851:CAS:528:DC%2BB3cXisFWisr%2FO758912510.3390/ijms21207485 JinYSuiHJDongYDingQQuWHYuSXJinYXAtorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathwaysActa Pharmacol Sin2012338618721:CAS:528:DC%2BC38XpsFOku7s%3D401115010.1038/aps.2012.59 Abdelkader NF, Elbaset MA, Moustafa PE, Ibrahim SM (2022) Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling. Arch Pharm Res 45(7):475-493. https://doi.org/10.1007/s12272-022-01391-5 YamaguchiTSasaseTMeraYDiabetic peripheral neuropathy in spontaneously diabetic tori-Lepr (fa) (SDT Faty) ratsJ Vet Med Sci20127412166916731:CAS:528:DC%2BC3sXitVensr4%3D10.1292/jvms.12-0149 KitadaMOguraYKoyaDRodent models of diabetic nephropathy: their utility and limitationsInt J Nephrol Renovasc Dis201614927929010.2147/IJNRD.S103784 McAdooDJXuGYRobakGHughesMGChanges in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cordExp Neurol19991595385441:CAS:528:DyaK1MXmt1Cmurg%3D10.1006/exnr.1999.7166 LiYHuZChenBBuQLuWDengYZhuRShaoXHouJZhaoJLiHZhangBHuangYLvLZhaoYCenXTaurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathwayToxicol Lett2012215171:CAS:528:DC%2BC38XhsFymu7%2FL10.1016/j.toxlet.2012.09.019 LiFAbatanOIKimHBurnettDLarkinDObrosovaIGStevensMJTaurine reverses neurological and neurovascular deficits in Zucker diabetic fatty ratsNeurobiol Dis2006226696761:CAS:528:DC%2BD28Xls1aksrg%3D10.1016/j.nbd.2006.01.012 HinderLMVincentAMHayesJMMcLeanLLFeldmanELApolipoprotein E knockout as the basis of mouse models of dyslipidemia-induced neuropathyExp Neurol201329310211010.1016/j.expneurol.2012.10.002 CompstonAOn diabetic neuritis, with a clinical and pathological description of three cases of diabetic pseudo-tabes. By T. Davies Pryce MRCS, consulting surgeon to the Nottingham General Dispensary. Brain 1893: 16; 416–424. With Diabetic neuropathy. A clinical study of 150 cases. By M. Mencer Martin. From the Department of Diabetes, King's College Hospital, Denmark Hill, London, S.E., UK. Brain 1953: 76; 594–624Brain20111343137314010.1093/brain/awr280 BoultonAJVinikAIArezzoJCBrilVFeldmanELFreemanRMalikRAMaserRESosenkoJMZieglerDDiabetic neuropathies: a statement by the American Diabetes AssociationDiabetes Care20052895696210.2337/diacare.28.4.956 FeldmanELCallaghanBCPop-BusuiRZochodneDWWrightDEBennettDLBrilVRussellJWViswanathanVDiabetic neuropathyNat Rev Dis Prim201954110.1038/s41572-019-0092-1 KouZZLiCYHuJCYinJBZhangDLLiaoYHWuZYDingTQuJLiHLiYQAlterations in the neural circuits from peripheral afferents to the spinal cord: possible implications for diabetic polyneuropathy in streptozotocin-induced type 1 diabetic ratsFront Neural Circuits201486390520110.3389/fncir.2014.00006 SirdahMMProtective and therapeutic effectiveness of taurine in diabetes mellitus: a rationale for antioxidant supplementationDiabetes Metab Syndr20159556410.1016/j.dsx.2014.05.001 Diaz-RuizASalgado-CeballosHMontesSMaldonadoVTristanLAlcaraz-ZubeldiaMRíosCAcute alterations of glutamate, glutamine, GABA, and other amino acids after spinal cord contusion in ratsNeurochem Res20073257631:CAS:528:DC%2BD28XhtlGitbnO10.1007/s11064-006-9225-5 TesfayeSSelvarajahDGandhiRGreigMShilloPFangFWilkinsonIDDiabetic peripheral neuropathy may not be as its name suggests: evidence from magnetic resonance imagingPain2016157Suppl 1S72S8010.1097/j.pain.0000000000000465 WuPShiXLuoMInamULLiKZhangMMaJLiYLiuYZhangCLiuXLiSLiQChenXCheXPiaoFTaurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathwayAmino Acids202052871021:CAS:528:DC%2BC1MXisVyhtb%2FE10.1007/s00726-019-02810-6 MetwallyMMMEbraheimLLMGalalAAAPotential therapeutic role of melatonin on STZ-induced diabetic central neuropathy: a biochemical, histopathological, immunohistochemical and ultrastructural studyActa Histochem20181208288361:CAS:528:DC%2BC1cXhvVSiurjK10.1016/j.acthis.2018.09.008 CubillosSUrbinaMLimaLDifferential taurine effect on outgrowth from goldfish retinal ganglion cells after optic crush or axotomy. Influence of the optic tectumInt J Dev Neurosci2000188438531:CAS:528:DC%2BD3MXitlCjtQ%3D%3D10.1016/S0736-5748(00)00040-X El MesallamyHOEl-DemerdashEHammadLNEl MagdoubHMEffect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistanceDiabetol Metab Syndr2010246290731210.1186/1758-5996-2-46 HuangHKaurSHuYLab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regenerationRestor Neurol Neurosci2019375455521:CAS:528:DC%2BC1MXitl2hsLrK6938454 ShintaniTNodaMProtein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cellsJ Biochem20081442592661:CAS:528:DC%2BD1cXhtVyrsrbN10.1093/jb/mvn064 Sobrido-CameánDFernández-LópezBPereiroNLafuenteARodicioMCBarreiro-IglesiasATaurine promotes axonal regeneration after a complete spinal cord injury in lampreysJ Neurotrauma20203789990310.1089/neu.2019.6604 YuanXBJinMXuXSongYQWuCPPooMMDuanSSignalling and crosstalk of Rho GTPases in mediating axon guidanceNat Cell Biol2003538451:CAS:528:DC%2BD3sXivFCg10.1038/ncb895 WilliamsonRTChanges in the spinal cord in diabetes mellitusBr Med J190411221231:STN:280:DC%2BC3Mzit1Grsw%3D%3D235264710.1136/bmj.1.2246.122 KeelerABSuoDParkJDeppmannCDDelineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targetsMol Cell Neurosci20178266751:CAS:528:DC%2BC2sXnsV2rtr8%3D602637410.1016/j.mcn.2017.04.011 SistiFMDos SantosNAGdo Amaral L, Dos Santos ACThe neurotrophic-like effect of carvacrol: perspective for axonal and synaptic regenerationNeurotox Res2021398868961:CAS:528:DC%2BB3MXhtVKnur7F10.1007/s12640-021-00341-1 EvangelistaAFVannier-SantosMAde Assis SilvaGSSilvaDNJuizPJLNonakaCKVDos SantosRRSoaresMBPVillarrealCFBone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascadesJ Neuroinflamm20181518910.1186/s12974-018-1224-3 WangZQiuZGaoCSunYDongWZhangYChenRQiYLiSGuoYPiaoYLiSPiaoF2,5-Hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathwayPLoS ONE201712548703410.1371/journal.pone.0179388 JinRWangJLiMTangTFengYZhouSXieHFengHGuoJFuRLiuJTangYShiYGuoHWangYNieFLiJDiscovery of a novel benzothiadiazine-based selective aldose reductase inhibitor as potential therapy for diabetic peripheral neuropathyDiabetes20247334975101:CAS:528:DC%2BB2cXlvFKrsr0%3D10.2337/db23-0006 WuGFRenSTangRYXuCZhouJQLinSMFengYYangQHHuJMYangJCAntidepressant effect of taurine in chronic unpredictable mild stress-induced depressive ratsSci Rep201774989550406410.1038/s41598-017-05051-3 SelvarajahDWilkinsonIDEmeryCJHarrisNDShawPJWitteDRGriffithsPDTesfayeSEarly involvement of the spinal cord in diabetic peripheral neuropathyDiabetes Care2006292664266910.2337/dc06-0650 ZhouHXLiXYLiFYLiuCLiangZPLiuSZhangBWangTYChuTCLuLNingGZKongXHFengSQTargeting RPTPσ with lentiviral shRNA promotes neurites outgrowth of cortical neurons and improves functional recovery in a rat spinal cord contusion modelBrain Res2014158646631:CAS:528:DC%2BC2cXhsVOhsrrO10.1016/j.brainres.2014.08.048 FangHLiuCYangMLiHZhangFZhangWZhangJNeurotrophic factor and Trk signaling mechanisms underlying the promotion of motor recovery after acute spinal cord injury in ratsExp Ther Med2017146526561:CAS:528:DC%2BC1cXhvFWmtb7M548851210.3892/etm.2017.4516 OgurtsovaKda Rocha FernandesJDHuangYLinnenkampUGuariguataLChoNHCavanDShawJEMakaroffLEIDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040Diabetes Res Clin Pract201712840501:STN:280:DC%2BC1crgs1Cisw%3D%3D10.1016/j.diabres.2017.03.024 Reske-NielsenELundbaekKPathological changes in the central and peripheral nervous system of young long-term diabetics. II. The spinal cord and peripheral nervesDiabetologia1968434431:STN:280:DyaE3c7jtlejtg%3D%3D10.1007/BF01241031 Cheng F, Qin W, Yang AX, Yan FF, Chen Y, Ma JX (2021) Propofol alleviates neuropathic pain in chronic constriction injury rat models via the microRNA-140-3p/Jagged-1 peptide/Notch signaling pathway. Synapse 75(10):e22219. https://doi.org/10.1002/syn.22219 WangQSunGGaoCFengLZhangYHaoJZuoEZhangCLiSPiaoFBone marrow mesenchymal stem cells attenuate 2,5-hexanedione-induced neuronal apoptosis through a NGF/AKT-dependent pathwaySci Rep20166347151:CAS:528:DC%2BC28Xhs1emtr7I505045610.1038/srep34715 SchafferSWJongCJRamilaKCAzumaJPhysiologicalroles of taurine in heart and muscleJ Biomed Sci201017Suppl1S2299439510.1186/1423-0127-17-S1-S2 PetruskaJCMendellLMThe many functions of nerve growth factor: multiple actions on nociceptorsNeurosci Lett20043611681711:CAS:528:DC%2BD2cXjvVGlu7c%3D10.1016/j.neulet.2003.12.012 FischerTZWaxmanSGNeuropathic pain in diabetes–evidence for a central mechanismNat Rev Neurol2010646246610.1038/nrneurol.2010.90 ZhangYQHanSLiuCCZhengYWLiHGaoFBianYHLiuXLiuHBHuSRLiYXChenZJZhaoSGZhaoHTHADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β - cell function and preserving β - cell massNat Commun202314110201:CAS:528:DC%2BB3sXjvFequ7Y%3D995049110.1038/s41 ZZ Kou (3392_CR25) 2014; 8 Y Li (3392_CR27) 2012; 215 SW Schaffer (3392_CR43) 2010; 17 YQ Zhang (3392_CR61) 2023; 14 T Shintani (3392_CR46) 2008; 144 XB Yuan (3392_CR58) 2003; 5 KK Park (3392_CR40) 2010; 223 MX Li (3392_CR30) 2022; 17 R Jin (3392_CR22) 2024; 73 MMM Metwally (3392_CR34) 2018; 120 K Muramatsu (3392_CR35) 2020; 21 J Zhang (3392_CR59) 2018; 12 RT Williamson (3392_CR53) 1904; 1 NE Garrett (3392_CR17) 1997; 222 AB Keeler (3392_CR23) 2017; 82 M Zhang (3392_CR60) 2021; 53 AJ Boulton (3392_CR2) 2005; 28 CL Shen (3392_CR45) 2024; 1 P Wu (3392_CR55) 2020; 52 Q Wang (3392_CR51) 2016; 6 D Selvarajah (3392_CR44) 2006; 29 S Tesfaye (3392_CR50) 2016; 157 TZ Fischer (3392_CR16) 2010; 6 T Yamaguchi (3392_CR57) 2012; 74 E Reske-Nielsen (3392_CR42) 1968; 4 3392_CR500 DJ McAdoo (3392_CR32) 1999; 159 3392_CR700 FM Sisti (3392_CR48) 2021; 39 A Compston (3392_CR4) 2011; 134 SA El-Marasy (3392_CR10) 2023; 375 K Ogurtsova (3392_CR39) 2017; 128 NA Calcutt (3392_CR3) 2017; 127 AF Evangelista (3392_CR12) 2018; 15 S Cubillos (3392_CR5) 2000; 18 A Diaz-Ruiz (3392_CR6) 2007; 32 SE Eaton (3392_CR8) 2001; 358 GF Wu (3392_CR54) 2017; 7 J Menzie (3392_CR33) 2014; 46 PJ Dyck (3392_CR7) 1993; 43 MS Islam (3392_CR20) 2013; 2013 Q Wu (3392_CR56) 2021; 7 MM Sirdah (3392_CR47) 2015; 9 JC Petruska (3392_CR41) 2004; 361 HX Zhou (3392_CR62) 2014; 1586 EL Feldman (3392_CR14) 2019; 5 IG Obrosova (3392_CR38) 2001; 172 H Fang (3392_CR13) 2017; 14 RL Benton (3392_CR1) 2001; 893 H Huang (3392_CR19) 2019; 37 HO El Mesallamy (3392_CR11) 2010; 2 M Kitada (3392_CR24) 2016; 14 K Li (3392_CR29) 2019; 1155 JK Ferris (3392_CR15) 2020; 69 D Sobrido-Cameán (3392_CR49) 2020; 37 K Li (3392_CR28) 2019; 383 K Muramatsu (3392_CR37) 2021; 22 3392_CR450 K Muramatsu (3392_CR36) 2018; 1680 LM Hinder (3392_CR18) 2013; 293 3392_CR600 J Liu (3392_CR31) 2015; 30 FK El-Baz (3392_CR9) 2020; 2020 Y Jin (3392_CR21) 2012; 33 F Li (3392_CR26) 2006; 22 Z Wang (3392_CR52) 2017; 12 |
| References_xml | – ident: 3392_CR700 doi: 10.1016/j.neulet.2016.07.032 – volume: 17 start-page: 2157 year: 2022 ident: 3392_CR30 publication-title: Neural Regen Res doi: 10.4103/1673-5374.335830 contributor: fullname: MX Li – volume: 73 start-page: 497 issue: 3 year: 2024 ident: 3392_CR22 publication-title: Diabetes doi: 10.2337/db23-0006 contributor: fullname: R Jin – volume: 358 start-page: 35 year: 2001 ident: 3392_CR8 publication-title: Lancet doi: 10.1016/S0140-6736(00)05268-5 contributor: fullname: SE Eaton – volume: 7 start-page: 301 year: 2021 ident: 3392_CR56 publication-title: Cell Death Discov doi: 10.1038/s41420-021-00701-y contributor: fullname: Q Wu – volume: 5 start-page: 41 year: 2019 ident: 3392_CR14 publication-title: Nat Rev Dis Prim doi: 10.1038/s41572-019-0092-1 contributor: fullname: EL Feldman – volume: 893 start-page: 292 year: 2001 ident: 3392_CR1 publication-title: Brain Res doi: 10.1016/S0006-8993(00)02995-4 contributor: fullname: RL Benton – volume: 37 start-page: 899 year: 2020 ident: 3392_CR49 publication-title: J Neurotrauma doi: 10.1089/neu.2019.6604 contributor: fullname: D Sobrido-Cameán – volume: 69 start-page: 3 year: 2020 ident: 3392_CR15 publication-title: Diabetes doi: 10.2337/db19-0321 contributor: fullname: JK Ferris – volume: 53 start-page: 395 year: 2021 ident: 3392_CR60 publication-title: Amino Acids doi: 10.1007/s00726-021-02957-1 contributor: fullname: M Zhang – volume: 8 start-page: 6 year: 2014 ident: 3392_CR25 publication-title: Front Neural Circuits doi: 10.3389/fncir.2014.00006 contributor: fullname: ZZ Kou – volume: 6 start-page: 34715 year: 2016 ident: 3392_CR51 publication-title: Sci Rep doi: 10.1038/srep34715 contributor: fullname: Q Wang – volume: 215 start-page: 1 year: 2012 ident: 3392_CR27 publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2012.09.019 contributor: fullname: Y Li – volume: 39 start-page: 886 year: 2021 ident: 3392_CR48 publication-title: Neurotox Res doi: 10.1007/s12640-021-00341-1 contributor: fullname: FM Sisti – volume: 1155 start-page: 747 year: 2019 ident: 3392_CR29 publication-title: Adv Exp Med Biol doi: 10.1007/978-981-13-8023-5_65 contributor: fullname: K Li – volume: 14 start-page: 1020 issue: 1 year: 2023 ident: 3392_CR61 publication-title: Nat Commun doi: 10.1038/s41467-023-36680-0 contributor: fullname: YQ Zhang – volume: 128 start-page: 40 year: 2017 ident: 3392_CR39 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2017.03.024 contributor: fullname: K Ogurtsova – volume: 14 start-page: 652 year: 2017 ident: 3392_CR13 publication-title: Exp Ther Med doi: 10.3892/etm.2017.4516 contributor: fullname: H Fang – volume: 82 start-page: 66 year: 2017 ident: 3392_CR23 publication-title: Mol Cell Neurosci doi: 10.1016/j.mcn.2017.04.011 contributor: fullname: AB Keeler – volume: 222 start-page: 191 year: 1997 ident: 3392_CR17 publication-title: Neurosci Lett doi: 10.1016/S0304-3940(97)13383-3 contributor: fullname: NE Garrett – volume: 144 start-page: 259 year: 2008 ident: 3392_CR46 publication-title: J Biochem doi: 10.1093/jb/mvn064 contributor: fullname: T Shintani – volume: 1680 start-page: 115 year: 2018 ident: 3392_CR36 publication-title: Brain Res doi: 10.1016/j.brainres.2017.12.016 contributor: fullname: K Muramatsu – volume: 12 year: 2017 ident: 3392_CR52 publication-title: PLoS ONE doi: 10.1371/journal.pone.0179388 contributor: fullname: Z Wang – volume: 29 start-page: 2664 year: 2006 ident: 3392_CR44 publication-title: Diabetes Care doi: 10.2337/dc06-0650 contributor: fullname: D Selvarajah – volume: 293 start-page: 102 year: 2013 ident: 3392_CR18 publication-title: Exp Neurol doi: 10.1016/j.expneurol.2012.10.002 contributor: fullname: LM Hinder – volume: 37 start-page: 545 year: 2019 ident: 3392_CR19 publication-title: Restor Neurol Neurosci contributor: fullname: H Huang – volume: 30 start-page: 67 year: 2015 ident: 3392_CR31 publication-title: Metab Brain Dis doi: 10.1007/s11011-014-9572-x contributor: fullname: J Liu – volume: 32 start-page: 57 year: 2007 ident: 3392_CR6 publication-title: Neurochem Res doi: 10.1007/s11064-006-9225-5 contributor: fullname: A Diaz-Ruiz – volume: 43 start-page: 817 year: 1993 ident: 3392_CR7 publication-title: Neurology doi: 10.1212/WNL.43.4.817 contributor: fullname: PJ Dyck – volume: 134 start-page: 3137 year: 2011 ident: 3392_CR4 publication-title: Brain doi: 10.1093/brain/awr280 contributor: fullname: A Compston – volume: 15 start-page: 189 year: 2018 ident: 3392_CR12 publication-title: J Neuroinflamm doi: 10.1186/s12974-018-1224-3 contributor: fullname: AF Evangelista – volume: 2 start-page: 46 year: 2010 ident: 3392_CR11 publication-title: Diabetol Metab Syndr doi: 10.1186/1758-5996-2-46 contributor: fullname: HO El Mesallamy – volume: 2020 start-page: 1295492 year: 2020 ident: 3392_CR9 publication-title: Biomed Res Int doi: 10.1155/2020/1295492 contributor: fullname: FK El-Baz – volume: 127 start-page: 608 issue: 2 year: 2017 ident: 3392_CR3 publication-title: J Clin Invest doi: 10.1172/JCI88321 contributor: fullname: NA Calcutt – volume: 2013 year: 2013 ident: 3392_CR20 publication-title: J Diabetes Res doi: 10.1155/2013/149452 contributor: fullname: MS Islam – volume: 74 start-page: 1669 issue: 12 year: 2012 ident: 3392_CR57 publication-title: J Vet Med Sci doi: 10.1292/jvms.12-0149 contributor: fullname: T Yamaguchi – volume: 383 year: 2019 ident: 3392_CR28 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2019.111557 contributor: fullname: K Li – volume: 6 start-page: 462 year: 2010 ident: 3392_CR16 publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2010.90 contributor: fullname: TZ Fischer – volume: 12 start-page: 558 year: 2018 ident: 3392_CR59 publication-title: Front Neurosci doi: 10.3389/fnins.2018.00558 contributor: fullname: J Zhang – volume: 46 start-page: 31 year: 2014 ident: 3392_CR33 publication-title: Amino Acids doi: 10.1007/s00726-012-1382-z contributor: fullname: J Menzie – volume: 1 start-page: 122 year: 1904 ident: 3392_CR53 publication-title: Br Med J doi: 10.1136/bmj.1.2246.122 contributor: fullname: RT Williamson – volume: 120 start-page: 828 year: 2018 ident: 3392_CR34 publication-title: Acta Histochem doi: 10.1016/j.acthis.2018.09.008 contributor: fullname: MMM Metwally – volume: 22 start-page: 669 year: 2006 ident: 3392_CR26 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2006.01.012 contributor: fullname: F Li – volume: 14 start-page: 279 issue: 9 year: 2016 ident: 3392_CR24 publication-title: Int J Nephrol Renovasc Dis doi: 10.2147/IJNRD.S103784 contributor: fullname: M Kitada – volume: 223 start-page: 45 year: 2010 ident: 3392_CR40 publication-title: Exp Neurol doi: 10.1016/j.expneurol.2009.12.032 contributor: fullname: KK Park – ident: 3392_CR500 doi: 10.1007/s12272-022-01391-5 – volume: 33 start-page: 861 year: 2012 ident: 3392_CR21 publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2012.59 contributor: fullname: Y Jin – volume: 375 start-page: 110402 year: 2023 ident: 3392_CR10 publication-title: Chem Biol Interact doi: 10.1016/j.cbi.2023.110402 contributor: fullname: SA El-Marasy – volume: 172 start-page: 211 year: 2001 ident: 3392_CR38 publication-title: Exp Neurol doi: 10.1006/exnr.2001.7789 contributor: fullname: IG Obrosova – volume: 361 start-page: 168 year: 2004 ident: 3392_CR41 publication-title: Neurosci Lett doi: 10.1016/j.neulet.2003.12.012 contributor: fullname: JC Petruska – volume: 9 start-page: 55 year: 2015 ident: 3392_CR47 publication-title: Diabetes Metab Syndr doi: 10.1016/j.dsx.2014.05.001 contributor: fullname: MM Sirdah – volume: 52 start-page: 87 year: 2020 ident: 3392_CR55 publication-title: Amino Acids doi: 10.1007/s00726-019-02810-6 contributor: fullname: P Wu – volume: 18 start-page: 843 year: 2000 ident: 3392_CR5 publication-title: Int J Dev Neurosci doi: 10.1016/S0736-5748(00)00040-X contributor: fullname: S Cubillos – volume: 17 start-page: S2 issue: Suppl1 year: 2010 ident: 3392_CR43 publication-title: J Biomed Sci doi: 10.1186/1423-0127-17-S1-S2 contributor: fullname: SW Schaffer – volume: 157 start-page: S72 issue: Suppl 1 year: 2016 ident: 3392_CR50 publication-title: Pain doi: 10.1097/j.pain.0000000000000465 contributor: fullname: S Tesfaye – volume: 4 start-page: 34 year: 1968 ident: 3392_CR42 publication-title: Diabetologia doi: 10.1007/BF01241031 contributor: fullname: E Reske-Nielsen – volume: 1 start-page: 73 issue: 124 year: 2024 ident: 3392_CR45 publication-title: Nutr Res doi: 10.1016/j.nutres.2024.01.014 contributor: fullname: CL Shen – ident: 3392_CR600 doi: 10.1002/syn.22219 – volume: 7 start-page: 4989 year: 2017 ident: 3392_CR54 publication-title: Sci Rep doi: 10.1038/s41598-017-05051-3 contributor: fullname: GF Wu – volume: 159 start-page: 538 year: 1999 ident: 3392_CR32 publication-title: Exp Neurol doi: 10.1006/exnr.1999.7166 contributor: fullname: DJ McAdoo – volume: 28 start-page: 956 year: 2005 ident: 3392_CR2 publication-title: Diabetes Care doi: 10.2337/diacare.28.4.956 contributor: fullname: AJ Boulton – volume: 22 start-page: 10123 year: 2021 ident: 3392_CR37 publication-title: Int J Mol Sci doi: 10.3390/ijms221810123 contributor: fullname: K Muramatsu – ident: 3392_CR450 doi: 10.1007/s00726-018-2544-4 – volume: 1586 start-page: 46 year: 2014 ident: 3392_CR62 publication-title: Brain Res doi: 10.1016/j.brainres.2014.08.048 contributor: fullname: HX Zhou – volume: 21 start-page: 7485 year: 2020 ident: 3392_CR35 publication-title: Int J Mol Sci doi: 10.3390/ijms21207485 contributor: fullname: K Muramatsu – volume: 5 start-page: 38 year: 2003 ident: 3392_CR58 publication-title: Nat Cell Biol doi: 10.1038/ncb895 contributor: fullname: XB Yuan |
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| SubjectTerms | AKT protein Analytical Chemistry Antibodies Axonogenesis Biochemical Engineering Biochemistry Biomedical and Life Sciences Cerebral cortex Degeneration Diabetes Diabetes mellitus Diabetic neuropathy GAP-43 protein Growth factors Life Sciences Nerve growth factor Nerves Neurobiology Neurodegeneration Neurological complications Neurons Neuroprotection Original Article Peripheral neuropathy Phosphorylation Proteomics Spinal cord Spinal cord injuries Streptozocin Taurine TOR protein TrkA protein TrkA receptors |
| Title | Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway |
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